Ocular Delivery of Atenolol Loaded Microsponge in-situ Gel: Development, Characterization and in-vitro Evaluation
Archana Dhyani1★, Ganesh Kumar2★ Corresponding author
- 1School of Pharmacy, Graphic Era Hill University, Dehradun, Uttarakhand, INDIA.
- 2College of Pharmacy, Shiwalik Campus, Dehardun, Uttarakhand, INDIA.
CORRESPONDENCE
Archana Dhyani
School of Pharmacy, Graphic Era Hill University, Dehradun, Uttarakhand, INDIA.
Received: 17-04-2021; Revised: 28-07-2021; Accepted: 23-12-2021.
Volume 56, Issue 1S · pp. S75–S80 · PUBLISHED 2022 · DOI: 10.5530/ijper.56.1s.45
ABSTRACT
Aim/Background: The purpose of the study was to fabricate and evaluate atenolol loaded micro-sponge in-situgel. Materials and Methods: Oil in Oil Emulsion Solvent Diffusion Technique was used for formulation of microsponges by using different levels of polymers such as Eudragit RS-100 and Ethyl Cellulose. The prepared micro-sponges were evaluated for optical microscopy, percentage yield, drug content, entrapment efficiency and surface morphology studies. The micro sponges were loaded into in-situ gel. The gel was characterized for pH, rheological behavior, in vitro gelling capacity and in vitro drug release study. Results: The smicrosponges were found in the size range of 7.43 to 9.26μm. The formulation F1 has smallest particle size while F9 has largest size. The product yield varies from 66.98% to 89.87 %.The drug content was found to be maximum for formulation F8 which is 94.19%. Similarly, the entrapment efficiency was found maximum for formulation F8 which is 93.89%. The gel was characterized for pH. The pH of drug loaded microsponge gel were found in range of 7.43±0.27 to 9.26±0.61.Similarly, viscosity ranges from 32 to 39 cps. The data of in-vitro release shows that 60.12% drug was released up to 24hr. Conclusion: The mirosponges laden in situ gel was effectively prepared by oil in oil emulsion solvent diffusion method (O/O ESDM). Further, the formulation will provide benefits in terms of sustained/controlled release, reduces dosing frequency and provides better compliance to the patient.
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Dhyani, A., & Kumar, G. (2022). Ocular Delivery of Atenolol Loaded Microsponge in-situ Gel: Development, Characterization and in-vitro Evaluation. Indian Journal of Pharmaceutical Education and Research, 56(1S), S75–S80. https://doi.org/10.5530/ijper.56.1s.45