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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Protective Effects of Silymarin and/or Omega-3 Fatty Acids against Paracetamol-initiated Liver Toxicity in Rats

Rajesh A. Maheshwari1★, Divya Khemani1, Ashim Kumar Sen1, Ramachandran Balaraman1, Ramaswamy Velmurugan2, Dhanya B. Sen1★ Corresponding author

  1. 1Department of Pharmacy, Sumandeep Vidyapeeth (Deemed to be University), Piparia, Waghodia, Vadodara, Gujarat, INDIA.
  2. 2Drug Discovery R&D, Century Pharmaceutical Limited, Vadodara, Gujarat, INDIA.

CORRESPONDENCE

Rajesh A. Maheshwari

Department of Pharmacy, Sumandeep Vidyapeeth (Deemed to be University), Piparia, Waghodia, Vadodara, Gujarat, INDIA.

rajpharma2007@gmail.com

Received: 01-12-2020; Revised: 10-02-2021; Accepted: 03-05-2021.

Volume 56, Issue 1S · pp. S81–S88 · PUBLISHED 2022 · DOI: 10.5530/ijper.56.1s.46

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ABSTRACT

Background and Aim: The proposed experiment was planned to evaluate the potential protective function of aqueous extract of Silymarin (SL) concentrate and/or Omega-3 fatty acids (O3FAs) against PCM-initiated liver toxicity in rats. Materials and Methods: Thirty Wistar-albino rats (either of sex) were distributed among five equivalent groups as follows: Normal control group, PCM control group, PCM + SL group (25 mg/kg, p.o.), PCM + O3FAs group (300 mg/kg, p.o.), PCM + SL + O3FAs group. All the treatments were administered for 14 days. Hepatotoxicity was induced in all groups except Group I by injection of PCM (2 g/kg, i.p.) on 14th day post the administration of drugs. Results: Noticeable rise in the levels of AST, ALT, ALP, total bilirubin, direct bilirubin, MDA, TNF-α, IL-6, VEGF and CRP were seen alongside a substantial reduction in the levels of serum total protein content and antioxidant enzymes, SOD, GSH, catalase in PCM control group. Treatment with SL or O3FAs or SL + O3FAs exhibited a considerable alteration in abovementioned biomarkers. Conclusion: The study concluded that SL and/or O3FAs protected the liver against PCM-initiated liver toxicity. However, the significantly increased hepatoprotective effects of SL when combined with O3FAs insinuate a possible synergism.

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    Maheshwari, R. A., Khemani, D., Sen, A. K., Balaraman, R., Velmurugan, R., & Sen, D. B. (2022). Protective Effects of Silymarin and/or Omega-3 Fatty Acids against Paracetamol-initiated Liver Toxicity in Rats. Indian Journal of Pharmaceutical Education and Research, 56(1S), S81–S88. https://doi.org/10.5530/ijper.56.1s.46