Neuroprotective Role of Periplocin Against Aluminium Chloride-stimulated Alzheimer’s Disease in a Rat Model by Modulation of Oxidative Stress and Inflammation
Danni Li1, Xiaoxiao Man1, Xiaoxia Ma2, Jinbo Sun1★★ Corresponding author
- 1Department of Neurology, Central Hospital (Affiliated to Shandong First Medical University), Jinan, Shandong, CHINA.
- 2Digestive Endoscopy Center, Central Hospital (Affiliated to Shandong First Medical University), Jinan, Shandong, CHINA.
CORRESPONDENCE
Jinbo Sun
Department of Neurology, Central Hospital (Affiliated to Shandong First Medical University), Jinan, Shandong, 250031, CHINA.
Received: 21-06-2022; Revised: 24-09-2022; Accepted: 11-10-2022.
Volume 57, Issue 1 · pp. 147–154 · PUBLISHED 2023 · DOI: 10.5530/001954642194
ABSTRACT
Background: Alzheimer’s disease is a prevalent neurodegenerative condition marked by the assembly of ß-amyloid deposits inside the brain parenchyma. Aluminium is a neurotoxin molecule that generates oxidative stress linked to various neurological disorders. Objectives: This study focused on the neuroprotective effects of periplocin, a natural compound, against aluminium chloride (AlCl3)-stimulated diseased rat model. Materials and Methods: Four groups of twenty-four Sprague Dawley rats were established. For four weeks, the rats in the control group I was administered NaCl. AlCl3 was provided to the second group of rats. An hour before AlCl3 induction, rats in groups III and IV were given periplocin (25 and 50 mg/kg) orally. The rats were behaviourally examined before euthanization and analysis of the biochemical parameters was carried out after their sacrifice. Results: The learning ability and memory were impaired, lipid oxidation (MDA) was suppressed by antioxidant regulation (Reduced glutathione, Catalase, and Superoxide dismutase), and lactate dehydrogenase, Na+ K+ ATPase, acetylcholinesterase, and nitric oxide activity was inhibited upon periplocin administration. Additionally, the concentrations of inflammatory regulators such as Il-1β, TNF-α, and IL-6 were suppressed. Conclusion: Thus, periplocin might be a crucial neuroprotector against the advancement of Alzheimer’s disease.
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Li, D., Man, X., Ma, X., & Sun, J. (2023). Neuroprotective Role of Periplocin Against Aluminium Chloride-stimulated Alzheimer’s Disease in a Rat Model by Modulation of Oxidative Stress and Inflammation. Indian Journal of Pharmaceutical Education and Research, 57(1), 147–154. https://doi.org/10.5530/001954642194