Volume 57, Issue 1

2023 · pp. 1–309 · 39 articles

Volume: 57
Issue: 1
Published: 2023
Pages: 1–309
Articles: 39
Sections: 4
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article Commentary Letter to the Editor

In this issue

Review Article

Review
The Effect of Antioxidants and Cardiovascular Drugs in the Treatment of Cardiac Diseases
Swadesh Kumar Pattanik, Kishanta Kumar Pradhan
pp. 1–14 · DOI: 10.5530/001954642291 · Published
Background: Reactive oxygen species mediate oxidative stress, is one of the major causes of the athero-thrombotic process involved in the etiology of peripheralarterial disease, ischemic strokes, and heart attack. Angiot…
Review
Dipeptide Conjugates: An Important Class of Therapeutic Agents
Ankita Borse, Nirmala Shinde, Sachin Kawaduji Bhosale
pp. 15–21 · DOI: 10.5530/001954640093 · Published 2023
Dipeptide conjugates and conjugates of amino acids with heterocycles or other chemical entity are significant class of medicinal compounds with a wide range of biological actions including antibacterial, antiviral, antic…
Review
Pros and Cons of Animal Models: Special Emphasis on Anti-arthritic Clinical Evaluation Model
Chandra Kishore Tyagi, Vaibhav Tripathi
pp. 22–27 · DOI: 10.5530/001954641253 · Published 2023
Introduction: Generally, animal models are regarded as very useful tools for studying pathophysiology and the clinical aspects of the disease and are always used as the first step for investigating a prospective new ther…

Original Article

Article
Exploration of Project and Module-based Teaching Method in Pharmaceutical Microbiology Laboratory Courses for Undergraduate Pharmacy Students
Weihua Chu
pp. 28–32 · DOI: 10.5530/001954641319 · Published 2023
Background: Pharmaceutical microbiology is an important applied branch of microbiology and it’s provided broad knowledge and understanding with regards to the principles, techniques and processes involved in pharmaceutic…
Article
Optimization of Fast-dissolving Tablets of Ledipasvir-sofosbuvir Inclusion Complexes by Design of Experiments
Uday Kumar Thummala, Eswar Gupta Maddi, Prameela Rani Avula
pp. 33–44 · DOI: 10.5530/001954641530 · Published 2023
Background: Fast-dissolving tablets (FDTs) were aimed to be developed for the latest approved combination drugs for Hepatitis-C treatment, Ledipasvir (LDV) and sofosbuvir (SBV) which suffered with poor water solubility. …
Article
Assessment of Mucoadhesion Potential of Thiolated Pectin Extracted from Citrus limon
Rashed M. Almuqbil
pp. 45–52 · DOI: 10.5530/001954640001 · Published 2023
Aim: This study aimed to extract pectin from Citrus limon, synthesize thiolated pectin (TFP), and assess its mucoadhesion capability utilizing in-vitro and ex-vivo methodologies. Materials and Methods: Wilhelmy`s approac…
Article
Formulation and Evaluation of Nanosponges Loaded Hydrogel of Metformin Hydrochloride
Ashish Y Pawar, Khanderao R Jadhav, Sharayu P Rathod, Ashwini S Sanap, Milind J Umekar
pp. 53–61 · DOI: 10.5530/001954641980 · Published 2023
Objectives: The objective of the research is to formulate a nanosponges loaded hydrogel of Metformin Hydrochloride for the treatment of Psoriasis. Psoriasis is currently treated with a variety of topical and systemic the…
Article
Statistically Optimized Facile Development, Characterization and Evaluation of Niosomal Nasal Drug Delivery System of Ropinirole Hydrochloride: In vitro Drug Release, Cytotoxicity and ex vivo Permeability Studies
Regulagadda Suryanarayana, Anjaneyulu Vinukonda, Seema Saroj, Neelu Jain, Harish Pandey, VSA Pavan Rudrabhatla, Thrimurthulu Gode
pp. 62–73 · DOI: 10.5530/001954641874 · Published 2023
Introduction: Nasal route is an alluring route for direct drug delivery to the central nervous system (CNS), owing to its avoidance of the hepatic first-pass metabolism and deciphering the blood–brain barrier passage iss…
Article
Berberine Hydrochloride-loaded Liposomes Gel: Preparation, Characterization and Antioxidant Activity
Mengmeng Wang, Hongmei Xia, Xinying Yang, Qin Zhang, Yufan Li, Yu Wang, Ying Xia, Zili Xie
pp. 74–82 · DOI: 10.5530/001954642087 · Published 2023
Aim: Berberine hydrochloride is a Traditional Chinese Medicine component with antibacterial, antiviral, anti-inflammatory, antioxidant and lowering blood sugar effects. However, the application of berberine hydrochloride…
Article
Terminalia arjuna Bark Extract Reduces High Fat Diet Induced Cardiac Damage in Wistar Rats by Altering Biochemical and Histological Parameters
Priya Palanivelu, Vijayakumar Jagadesan, Rajagopalan Vijayaraghavan, Praveenkumar Parthiban, Madhankumar Swaminathan, Senthilkumar Sivanesan
pp. 83–93 · DOI: 10.5530/001954641032 · Published 2023
Objectives: The aim of the present study was to examinethe protective effect of bark extract of TA (Terminalia arjuna) on HFD (high fat diet) induced biochemical and histopathological changes in Wistar rats. Materials an…
Article
Anxiolytic Potential of Chloroform Extract of Ziziphus mauritiana Lam. Leaves in Mice
Rakesh Kumar, Gurinder Kaur, Atamjit Singh, Jaijeet Singh, Balbir Singh, Sarabjit Kaur
pp. 94–100 · DOI: 10.5530/001954641261 · Published 2023
Introduction: With a tremendous spike in the cases of anxiety in recent years, scientists are looking for herbal drug alternatives for its treatment as all the conventional medication options available in the market have…
Article
Comparative Extraction and Quantification of Scutellarein from Leaves of Triumfetta rhomboidea Using RP-HPLC
Nutan Kendre, Pravin Wakte
pp. 101–106 · DOI: 10.5530/001954641137 · Published 2023
Aim: The purpose of this paper was to develop a sensitive, reproducible Reverse Phase High Performance Liquid Chromatography (RP-HPLC) for extraction and quantitative estimation of Scutellarein, major flavone glycoside f…
Article
Linalol and Linalyl Acetate Quantitation in the Essential Oil of Somatic Embryos of Bursera linanoe R.
Horacio Larqué, Eugenio Sánchez-Arreola, Gregorio Arellano-Ostoa, Luis R. Hernández, Horacio Bach, Abelardo Chávez-Montes
pp. 107–112 · DOI: 10.5530/001954641346 · Published 2023
Introduction: Mexican artisans use the linaloe tree for the production of handcrafts. The extracted oil from the endangered Mexican tree Bursera linanoe which main components are the terpenes linalol and linalyl acetate …
Article
Antifungal Activity of Cymbopogon flexuosus Essential Oil and its Effect on Biofilm Formed by Candida parapsilosis and Candida tropicalis on Polystyrene and Polyvinyl Plastic Surfaces
Abdullah A. Al-Ghanayem
pp. 113–119 · DOI: 10.5530/001954641705 · Published 2023
Aim: To determine the antifungal and antibiofilm activity of Cymbopogon flexuosus (Lemongrass oil) against C. parapsilosis and C. tropicalis. Materials and Methods: Lemongrass oil, was analyzed by GC-MS. Antifungal activ…
Article
Phytochemical Analysis and in vitro Cell Viability Effects of Ethanolic Extract of Ormocarpum cochinchinense on Mouse Embryonic Fibroblasts
Gayathri Somashekar, Uma Sudhakar, Seshadri Srividya, Snophia Suresh
pp. 120–124 · DOI: 10.5530/001954641931 · Published 2023
Background: Ormocarpum cochinchinense is a medicinal herb known to be used by traditional bone setters for the healing of bone fractures. This herb has many active biomolecules, which are responsible for biological activ…
Article
Selected Essential Oils as Natural Ingredients in Cosmetic Emulsions: Development, Stability Testing and Antimicrobial Activity
Rezarta Shkreli, Rihana Terziu, Lorena Memushaj, Klodiola Dhamo, Ledjan Malaj
pp. 125–133 · DOI: 10.5530/001954642109 · Published 2023
Background: Essential oils are currently the subject of intensive scientific study, and their potential as active medicinal compounds or natural preservatives has attracted the attention of the cosmetic and pharmaceutica…
Article
Visnagin Mitigates Glycerol-induced Acute Kidney Injury in Rats through Decreasing Inflammation, Oxidative Stress, and Renal Dysfunction Markers
Junhong Wan, Qian Xu, Tahani Awad Alahmadi, Prabakaran DS, Min Liu
pp. 134–140 · DOI: 10.5530/001954642201 · Published 2023
Background: Acute kidney injury (AKI) is a heterogenous condition, characterized by dysregulated kidney function along with reduced glomerular filtration, solute excretion, and urine output. Objectives: This work was foc…
Article
Monitoring of Defense Enzymes (Phenylalanine Ammonia Lyase and Peroxidase) in Magnaporthe oryzae Infected Leaves after Treatment with Green Synthesized Silver Nanoparticles
Bahareh Bakhshi, Sudhakar Malla, S Lokesh
pp. 141–146 · DOI: 10.5530/001954642708 · Published 2023
Objectives: In this study, we focus on the amount of the two defence enzymes phenylalanine ammonia-lyase (PAL) and peroxidase (POX) expressed with regard to the treatment of green synthesized silver nanoparticles. Materi…
Article
Neuroprotective Role of Periplocin Against Aluminium Chloride-stimulated Alzheimer’s Disease in a Rat Model by Modulation of Oxidative Stress and Inflammation
Danni Li, Xiaoxiao Man, Xiaoxia Ma, Jinbo Sun
pp. 147–154 · DOI: 10.5530/001954642194 · Published 2023
Background: Alzheimer’s disease is a prevalent neurodegenerative condition marked by the assembly of ß-amyloid deposits inside the brain parenchyma. Aluminium is a neurotoxin molecule that generates oxidative stress link…
Article
Methylmercury, Mn2+ and Pb2+ Exposure Promotes Premature Proliferation/Differentiation of Human Neural Stem Cells in Different Ways
Wenyan Ying, Tongbing Qi, Dongzi Shi, Jing Zhang, Ganghui Ye, Xuewen Tian, Qinglu Wang
pp. 155–160 · DOI: 10.5530/001954641252 · Published 2023
Background: Methylmercury (MeHg), manganese ions (Mn2+), and lead ions (Pb2+) are ubiquitous environmental pollutants and may be neurotoxic especially during fetal development. We decided to explore the toxic mechanisms …
Article
Piperine Induces Cell Death, Apoptosis and Inhibits Migration in Cholangiocarcinoma Cells
Benjaporn Buranrat, Laddawan Senggunprai, Auemduan Prawan, Veerapol Kukongviriyapan
pp. 161–166 · DOI: 10.5530/001954641324 · Published 2023
Background/Aim: Piperine (Pip) is an alkaloid that found from natural products and it has been reported to exert anticancer activities. Nevertheless, its anticancer effect has not yet been illustrated in cholangiocarcino…
Article
Troxerutin, a Bioflavonoid Exhibits Oxidative Stress-induced Cytotoxic Effects on KB Cells
Li Tan, Huanping Ding, Haimeng Xi
pp. 167–172 · DOI: 10.5530/001954642011 · Published 2023
Background: The prevalence of oral cancer is high and it is the sixth most occurring cancer in the world. Some of the drugs used to treat oral cancer cause adverse effects and are resistant to treatment. Objectives: This…
Article
Investigation of Cardioprotective Effect of 2, 4-thiazolidinedione Derivative Using HFD-STZ Fed Rats
Heli H Amin, Nileshkumar Joitaram Patel, Nikita Patel, Dolar Govindbhai Patel
pp. 173–181 · DOI: 10.5530/001954640215 · Published 2023
Background: Myocardial infarction is a 2nd most important origin of universal death and after coronary revascularization, cardiovascular events occurs further a lot in subjects through DM: 3.5- as well as 2-fold fatality…
Article
Design, Synthesis and Molecular Docking Studies of (S)-1-(2-(substituted benzylamino)-3-methylbutanoyl)pyrrolidin-2-one analogues as GABA Mediated Anticonvulsant Agents
Obaid Afzal, Gopal Prasad Agrawal, Ghadah Rashed Ghazi Alotaibi, Raid Saleh Ali Shatat, Habibullah Khalilullah, Zabih Ullah, Mohammad Rashid, Ahmed F Elkirdasy, Benson Mathai K
pp. 182–193 · DOI: 10.5530/001954641726 · Published 2023
Background: Epilepsy is a deep rooted, partially curable brain illness that affects all individuals irrespective of ages and genders. Despite the discovery of various innovative antiepileptic drugs (AEDs), selectivity an…
Article
QSAR and Molecular Docking Studies of 5-benzylideno-2-adamantylthiazol[3,2-b][1,2,4]triazol-6(5H)ones Derivatives as Antimicrobial Activity
Trupti S Chitre, Sheetal Parse, Kalyani Asgaonkar, Vijay Khedekar, Shivani Jadhav, Kunal Pradhan
pp. 194–201 · DOI: 10.5530/001954641712 · Published 2023
Aim and Background: Bacterial Infection is a leading cause of death worldwide. Triazoles and thiazolinones (fused) have been reported to possess many biological activities including antibacterial activity. To study 2D an…
Article
Synthesis, Anticonvulsant, and Molecular Docking Studies of (3,5-disubstituted-4,5-dihydro-1H-pyrazol-1-yl) (4-chlorophenyl) Methanone Derivatives
Pushkar Kumar Ray, Salahuddin, Avijit Mazumder, Rajnish Kumar, Mohamed Jawed Ahsan, Mohammad Shahar Yar
pp. 202–209 · DOI: 10.5530/001954641727 · Published 2023
Aim/Background: This research work aims to design and synthesize novel compounds containing pyrazoline moiety in their structure with enhanced anticonvulsant activity in comparison with the standard (Phenytoin) drug. In …
Article
Design, Synthesis, Characterization, and Anti-Cancer Activity Evaluation of Novel Thiosemicarbazide Analogs
Akhalesh Kumar, Rakhi Mishra, Rupa Mazumder, Avijit Mazumder
pp. 210–217 · DOI: 10.5530/001954641768 · Published 2023
Aim/Background: Across the world disease of cancer is one of the factors of death and to identify the emerging role of thiosemicarbazide analogs for the cancer disease it was decided to design, and synthesize novel thios…
Article
Discovery of A Novel Synthetic Thiazole-benzimidazole Conjugate that Acts as a Potent Pancreatic Lipase Inhibitor using in silico and in vitro Approaches
Amr Salah Abouzied, Mohammed Khaled Bin Break, Bader Huwaimel, Weiam Hussein, Ahmed Alafnan, Kareem Mahmoud Younes
pp. 218–227 · DOI: 10.5530/001954642131 · Published 2023
Aim/ Background: Pancreatic lipase (PL) inhibition has been suggested to be an effective method for obesity management. In this study, 10 novel thiazole-benzimidazole conjugates were designed. Materials and Methods: Conj…
Article
Derivative Spectrophotometric Method Development and Validation for the Estimation of Evogliptin Tartrate in Pharmaceutical Dosage Form
Khushbu Patel, Ujash Shah, Hirak Joshi, C.N Patel
pp. 228–233 · DOI: 10.5530/001954640245 · Published 2023
Aim: A simple and economic method was developed as a derivative spectrophotometric study for estimation of evogliptin tartrate in the tablet dosage form. The developed derivative method was validated as per the ICH guide…
Article
Area under Curve Method for the Simultaneous Quantitative Estimation of Pravastatin Sodium and Aspirin
Naveen Kumar KL, Ramgopal Dhanwad, Niranjan MS, KC Chaluvaraju
pp. 234–241 · DOI: 10.5530/001954640307 · Published 2023
In the present study an economic, a precise UV-spectrosphotometric method for estimating Aspirin and Pravastatin sodium in bulk and physical mixture is carried out as there is less paucity of literature on simultaneous e…
Article
Development and Validation of Chemometric Assisted UV Methods for the Simultaneous Determination of Ambroxol Hydrochloride, Terbutaline Sulphate and Guaiphenesin in Pharmaceutical Dosage Form
Keerthisikha Palur, Sreenivasa Charan Archakam, Bharathi Koganti
pp. 242–249 · DOI: 10.5530/001954641128 · Published 2023
Aim: The present study aimed to develop and validate chemometric assisted UV spectrophotometric methods for the simultaneous determination of ambroxol hydrochloride (ABH), terbutaline sulphate (TES) and guaiphenesin (GPN…
Article
Simultaneous Estimation of Atovaquone and Mefloquine Hydrochloride: QbD based Method Development and Validation
Sanyam Sharma, Subh Naman, Kamya Goyal, Ashish Baldi
pp. 250–263 · DOI: 10.5530/001954641318 · Published 2023
Background: Atovaquone are important drugs that are used in the treatment of malaria and in combination with mefloquine hydrochloride increases the efficacy and potency. Present study covers the development of UV-spectro…
Article
A New Stability Indicating HPLC-PDA Method for Estimation of Eluxadoline in Presence of its Degradation Products
Poonam Patil, Tara Shankar Basuri, Sonal Desai
pp. 264–270 · DOI: 10.5530/0019546402522 · Published 2023
Background: The goal of proposed study was to optimize and validate reversed phase high performance liquid chromatography (RP-HPLC) method for assessment of eluxadoline in presence of its forced degradation products in i…
Article
Development and Validation of Highly Precise Methods for the Spectrophotometric Determination of Cefpirome in Pharmaceutical Dosage Forms
Basavaraj Hiremath, Nagesh Gunavanthrao Yernale, Mahadev Dhanraj Udayagiri
pp. 271–277 · DOI: 10.5530/001954640247 · Published 2023
Aim: Cefpirome (CFP) in pure and pharmaceutical dosage forms determination by spectrophotometer; two very sensitive techniques have been developed. Materials and Methods: By mixing alkaline β-Naphthol (2-NPL) with diazot…
Article
Validation of Rapid and Simple HPLC-UV Method for Diflunisal Determination in Bulk Drug and Human Plasma
Miglena Smerikarova, Stanislav Bozhanov, Vania Maslarska
pp. 278–285 · DOI: 10.5530/001954641926 · Published 2023
Background: Transthyretin amyloidosis is a rare disease currently under wide investigation and many different therapeutic agents were developed for its control and treatment. In addition to the newly discovered drugs, it…
Article
Implementation of Telepharmacy Services in Community Pharmacy – Pharmacists’ Perspective in Republic of Serbia
Jovana Ilkić, D. Obradović, Andrijana Milošević Georgiev, Valentina Marinković, Ivana Tadić
pp. 286–294 · DOI: 10.5530/001954641895 · Published 2023
Aim/Background: COVID-19 pandemic has casted a new light over the capacity of telepharmacy to increase access to pharmaceutical care, providing more support to patients and allowing new opportunities for pharmacists. How…
Article
Flat Foot and Associated Factors among University Students Aged 18-25 Years: A University-Based Study
Manoj Kumar Vashisth, Yu Mi, Xiaolin Ye, Xiumei Wu, Zhizhong Mi, Xianzhang Tian, Bensi Zhang
pp. 295–300 · DOI: 10.5530/001954641962 · Published 2023
Background: In various human postural studies, foot is considered to be a rigid body. The flat foot, also referred to as the acquired disorder of the flat foot, results from the subsidence of the arches of the feet. Usua…

Commentary

Article
“Drug Repurposing” Policies and Statutes: Lessons from the COVID-19 Pandemic: A Review
Srividya Ravi, Sammita Jadhav, Ravindra Ghooi
pp. 301–307 · DOI: 10.5530/001954641939 · Published 2023
Introduction: Repurposed drugs are not eligible for patent protection in India vide Sec 3 (d) of the Indian Patent Act, 1970. The data generated to establish the therapeutic efficacy of the repurposed drugs for the new i…

Letter to the Editor

Article
A Case for Chirality - chiralpedia.com
Valliappan Kannappan
pp. 308–309 · DOI: 10.5530/001954640002 · Published 2023
The Pharmacy degree course curriculum marks the most crucial stage of conventional pedagogy because specialized discipline-based, content-oriented courses in pharmaceutical and allied areas of knowledge are introduced at…