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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Terminalia arjuna Bark Extract Reduces High Fat Diet Induced Cardiac Damage in Wistar Rats by Altering Biochemical and Histological Parameters

Priya Palanivelu1, Vijayakumar Jagadesan2, Rajagopalan Vijayaraghavan3, Praveenkumar Parthiban3, Madhankumar Swaminathan3, Senthilkumar Sivanesan3,4★★ Corresponding author

  1. 1Department of Anatomy, KMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, INDIA.
  2. 2Department of Anatomy, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, INDIA.
  3. 3Department of Research and Development, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, INDIA.
  4. 4Department of Biosciences, Institute of Biotechnology, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, INDIA.

CORRESPONDENCE

Senthilkumar Sivanesan

Department of Research and Development, Saveetha Institute of Medical and Technical Sciences, Chennai-602105, Tamil Nadu, INDIA.

senbio@gmail.com

Received: 26-10-2021; Revised: 27-05-2022; Accepted: 10-08-2022.

Volume 57, Issue 1 · pp. 83–93 · PUBLISHED 2023 · DOI: 10.5530/001954641032

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ABSTRACT

Objectives: The aim of the present study was to examinethe protective effect of bark extract of TA (Terminalia arjuna) on HFD (high fat diet) induced biochemical and histopathological changes in Wistar rats. Materials and Methods: Group 1 – control rats received water ad libitum, Group 2 – HFD group received corn oil orally at a dose of 10mL/kg, Group 3 (HFD+ Atorvastatin (ATV) 10mg/kg), Group 4 (HFD+TA125 mg/kg), and Group 5 (HFD+TA250 mg/kg) were treated as indicated 6 days a week for 5 consecutive weeks. Serum lipid profile and LCAT enzyme activity were evaluated followed by antioxidant parameters and histopathological assessment of heart tissue. Results: HFD group showed elevated levels of lipid profile and alterations in antioxidant parameters, LCAT enzyme activity and histology of heart as compared with control group. Administration of standard drug Atorvastatin (10mg/kg), aqueous bark extract of T. arjuna (125 and 250 mg/kg) to HFD group protected the biochemical alterations, LCAT enzyme activity and pathological damage caused to heart tissue. Conclusion: The study findings reveal the protective role of T. arjuna on HFD induced biochemical and cardiovascular changes implicating antioxidant and therapeutic potential.

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    Palanivelu, P., Jagadesan, V., Vijayaraghavan, R., Parthiban, P., Swaminathan, M., & Sivanesan, S. (2023). Terminalia arjuna Bark Extract Reduces High Fat Diet Induced Cardiac Damage in Wistar Rats by Altering Biochemical and Histological Parameters. Indian Journal of Pharmaceutical Education and Research, 57(1), 83–93. https://doi.org/10.5530/001954641032