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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Berberine Hydrochloride-loaded Liposomes Gel: Preparation, Characterization and Antioxidant Activity

Mengmeng Wang1, Hongmei Xia1★, Xinying Yang1, Qin Zhang1, Yufan Li1, Yu Wang1, Ying Xia1, Zili Xie2★ Corresponding author

  1. 1College of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei, CHINA.
  2. 2Anhui Institute for Food and Drug Control, Hefei, CHINA.

CORRESPONDENCE

Hongmei Xia

Anhui University of Traditional Chinese Medicine, Longzihu Road, Hefei City, Anhui-230011, CHINA.

sm_shine@ahtcm.edu.cn

Received: 03-06-2022; Revised: 13-09-2022; Accepted: 11-10-2022.

Volume 57, Issue 1 · pp. 74–82 · PUBLISHED 2023 · DOI: 10.5530/001954642087

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ABSTRACT

Aim: Berberine hydrochloride is a Traditional Chinese Medicine component with antibacterial, antiviral, anti-inflammatory, antioxidant and lowering blood sugar effects. However, the application of berberine hydrochloride has been hindered for a long time due to its poor solubility and low bioavailability. This study aims to design a liposomes-gel to enhance the bioavailability and antioxidant activity of berberine hydrochloride. Materials and Methods: The thin-film dispersion hydration method was used to prepare liposomes, and liposomes-gel was prepared by the natural swelling method using sodium alginate as the hydrogel matrix. Berberine hydrochloride-loaded liposomes-gel was characterized by the encapsulation efficiency, particle size, potential, and transmission electron microscopy, and studied by in vitro release and antioxidant activity of the preparations. Results: The results revealed the encapsulation efficiency of berberine hydrochloride-loaded liposomes was 79.62±4.20% and the mean particle size was 153.7±11.2 nm. The release of berberine hydrochloride from liposomes-gel conformed to a first-order release model. The scavenging rate of DPPH free radicals and H2O2 by berberine hydrochloride-loaded liposomes-gel exceeds 70%. Conclusion: The liposomes-gel has a sustained-release effect on berberine hydrochloride. Berberine hydrochloride-loaded liposomes-gel had good antioxidant properties by measuring the scavenging ability on DPPH free radicals, H2O2 and lipid peroxidation resistance.

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    Wang, M., Xia, H., Yang, X., Zhang, Q., Li, Y., Wang, Y., Xia, Y., & Xie, Z. (2023). Berberine Hydrochloride-loaded Liposomes Gel: Preparation, Characterization and Antioxidant Activity. Indian Journal of Pharmaceutical Education and Research, 57(1), 74–82. https://doi.org/10.5530/001954642087