Volume 57, Issue 1S

2023 · pp. s85–s97 · 22 articles

Volume: 57
Issue: 1S
Published: 2023
Pages: s85–s97
Articles: 22
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
Orphan Drug Pricing and Cost Trends in USA: An Analysis of Impact of Orphan Drug ACT
Sangita Mishra, Venkatesh Madhugiri Prakash
pp. s1–s6 · DOI: 10.5530/ijper.57.1s.1 · Published 2023
Objectives: The study analyses the impact of incentives in Orphan Drug Act on Orphan Drug revenue strategies of pharmaceutical and biotechnology companies in USA and proposes policies and steps to address the same. Resul…
Review
Transmissible Spongiform Encephalopathy and its Regulations
S Monika, V Balamuralidhara
pp. s7–s12 · DOI: 10.5530/ijper.57.1s.2 · Published 2023
Bovine Spongiform Encephalopathy (BSE) has a place with the uncommon cluster of continuously progressive neurological infections identified as Transmissible Spongiform Encephalopathies (TSEs). TSE sicknesses are describe…

Original Article

Article
Assessment of Solid-State Behaviour and in vitro Release of Artemether from Liquisolid Compact Using Mesoporous Material as an Excipient
Archana Manjunath, Sayani Bhattacharyya
pp. s13–s21 · DOI: 10.5530/ijper.57.1s.3 · Published 2023
Background: Artemether is a potent antimalarial drug used in the first-line treatment of multi-drug-resistant malaria. It belongs to BCS II, exist in different polymorphic forms, and exhibits incomplete absorption and lo…
Article
Production of L-tyrosinase from Novel Variants of Streptomyces cellulosae
G Sowjanya, G Girijasankar
pp. s22–s31 · DOI: 10.5530/ijper.57.1s.4 · Published 2023
Background: Recently, a lot of interest has been focused on the discovery of high L-tyrosinase yielding microorganisms that catalyze the production of enantiomerically pure L-DOPA, which has been recognized as the conven…
Article
Effect of Process Variables on the Development and Characterization of Nanocellulose as Novel Biopolymer
Pradeep Heregangur Keshavamurthysetty, Dipti Hiteshkumar Patel
pp. s32–s40 · DOI: 10.5530/ijper.57.1s.5 · Published 2023
Nanocellulose has excellent mechanical, physical, and biological properties; it is an ideal material for many applications. The present study aimed to develop nanocellulose from cellulose by hydrolyzing with sulphuric ac…
Article
Development and Evaluation of Fast Dissolving Oral Films of Mefenamic Acid for the Management of Fever
Krishnameera Sajayan, Swathy KK, Sarath Chandran C, Jafna MC, Rajesh Sreedharan Nair, Sourav K, Shijina Kappally, Sreejith KR, Jim Joseph
pp. s41–s51 · DOI: 10.5530/ijper.57.1s.6 · Published 2023
The marketed formulations of Mefenamic Acid (MA) used for the treatment of fever in the paediatric population are reported to have several drawbacks. This study aimed to develop and evaluate the mefenamic acid–loaded ora…
Article
Formulation and Evaluation of Aspirin-PLGA Microsphere for the Dental Stem Cell Stimulation
Litha Thomas, Preeti Karwa, V Kusum Devi
pp. s52–s62 · DOI: 10.5530/ijper.57.1s.7 · Published 2023
Aim: According to WHO, dental caries is the most prevalent oral disease, and its progression leads to tooth loss. Clinical management of caries focuses on the severity and extent of disease with the main aim, i.e., the ‘…
Article
Formulation and Evaluation of Niosomal Gel Loaded with Asparagus racemosus Extract for Anti-inflammatory Activity
Nikhilkumar Yeshwanth Hegdekar, Sneh Priya, Suchith S Shetty, Divya Jyothi
pp. s63–s74 · DOI: 10.5530/ijper.57.1s.8 · Published 2023
Background/Aim: Inflammation typically occurs when infectious microorganisms enter the body, settle in specific tissues, and/or circulate in the blood. Asparagus racemosus extract contains various saponins and flavonoids…
Article
Formulation and Evaluation of Castor Oil Containing Self-emulsifying Pellets by Using Design of Experiment
Shubhangi V Shekade, Sanjeevani S Deshkar, Satish V Shirolkar
pp. s75–s84 · DOI: 10.5530/ijper.57.1s.9 · Published 2023
Background/Objectives: The objective of the study was to examine the feasibility of extrusion/spheronization techniques for formulation of castor oil loaded self-emulsifying pellets. The study was also aimed at optimizat…
Article
Terbinafine HCl Film-Forming Spray for the Treatment of Topical Fungal Infections
Nidamanuri Bala Sai Soujith, Natarajan Jawahar
pp. s85–s97 · DOI: 10.5530/ijper.57.1s.10 · Published 2023
Terbinafine HCl is an allylamine used to treat fungal infections. It has substantial side effects that can be mitigated by using a topical semisolid dose form. The objective of this study was to develop a 1% Terbinafine …
Article
Synthesis, Antidiabetic Evaluation and Molecular Docking Studies of Thiazolidine-2,4-Dione Analogues
Dolly R Pardeshi, Vithal M Kulkarni, Sandeep S Pathare
pp. s98–s104 · DOI: 10.5530/ijper.57.1s.11 · Published 2023
Introduction: Diabetes Mellitus is a disorder of metabolism described by high glucose levels. The disorder kills a larger number of individuals consistently than of malignant growth and AIDS combined. Presently available…
Article
Analog-based Design and Development of Novel Molecules as Anti-tubercular Agents
Satheeshkumar Sellamuthu, Mohan Sellapan, Kandasamy CS, Dileep Kumar, Kavitha Kasimayan, Sasikala Manickavasagam
pp. s105–s113 · DOI: 10.5530/ijper.57.1s.12 · Published 2023
Background: The burden of tuberculosis is immense as most of the drugs developed resistance to Mycobacterium tuberculosis (Mtb). This issue shall be addressed by developing new drugs acting through novel mechanisms. GSK …
Article
An Alternative Excipient from Vegetable Source for Oral Drug Dosage Forms to Regulate Drug Delivery
Gatla Venkata Amruthavalli, Arumugam Vijayalakshmi
pp. s114–s125 · DOI: 10.5530/ijper.57.1s.13 · Published 2023
Introduction: Tablet is the preferred drug dosage form. Cellulose fiber (Micro Crystalline Cellulose) is the major excipient used. For chronic diseases, frequent dosage is required resulting in cumulative excipient load …
Article
Preparation and in-vitro and in-vivo Evaluation of Ayurvedic Formulation “Amruthotharam” Formulated by Classical and Modern Technique
Ketaki Dhane, Manish Kumar Gupta, Supriya Hyam, Abhinandan Patil
pp. s126–s134 · DOI: 10.5530/ijper.57.1s.14 · Published 2023
Glucose intolerance, central obesity, hypertension, and dyslipidemia are all part of the metabolic syndrome. Thus, a number of theories have been put out to explain the development of the metabolic syndrome, including an…
Article
Evaluation of Immunomodulatory Effect of Aqueous Extract of Bauhinia variegata L. Leaves
Santanu Saha, EVS Subrahmanyam
pp. s135–s139 · DOI: 10.5530/ijper.57.1s.15 · Published 2023
Natural products have the potential to modulate the immunity of human beings either by stimulating or depressing it and the approach was being used over time by medicinal practitioners to treat ailments. This present stu…
Article
Cost-Minimization Analysis of Medications Used in the Management of End-stage Renal Disease
Jarupala Gangadhar Naik, Sreedhar Dharmagadda, Pradeep Manohar Murugundi, Virendra Ligade, Shankar Prasad Nagaraju, Manjunath Kulkarni
pp. s140–s147 · DOI: 10.5530/ijper.57.1s.16 · Published 2023
Aim/Background: Several branded pharmaceuticals and generic medicines are available in the market for the management of End-Stage Renal Disease (ESRD) as a supportive care, and clinicians are unaware of the cost minimiza…
Article
Prevalence of Drug-Related Problems in Elderly Cancer Patients: A Prospective Observational Study in a Cancer Specialty Hospital
Acsah Annie Paul, Madhan Ramesh, KG Srinivas
pp. s148–s152 · DOI: 10.5530/ijper.57.1s.17 · Published 2023
Background: The geriatric population comprises the majority of patients with oncological disorders. They are highly vulnerable to drug-related problems (DRPs) due to multiple comorbidities, polypharmacy, altered pharmaco…
Article
Medication Reconciliation Practices in Two Multispeciality Hospitals
Allwin Kunjachen Syju, Chelsiya P Abraham, Princy Sara Korath, Reenu Sara Jacob, Savitha R Sanathan, Anjali Arun
pp. s153–s159 · DOI: 10.5530/ijper.57.1s.18 · Published 2023
Background: Medication errors are common and can compromise patient safety. Commonly seen at discharge, they can be identified and resolved even during admission. Medication reconciliation is recommended to prevent error…
Article
Perceptions of Indian Physicians towards Deprescribing of Medications for Chronic Diseases in Elderly: A Questionnaire-based Study
Shribhavana Jawahar, Lakshmipriya Selvaraj, Kailash Muruganantham, Iniya Kumar, Vanitha Rani Nagasubramanian
pp. s160–s166 · DOI: 10.5530/ijper.57.1s.19 · Published 2023
Deprescribing is the process of reconstructing multiple medications use by review and analysis, which concludes with the modification, replacement or elimination of drugs. Medications that were once appropriate may becom…
Article
A Meta-Analysis on Misuse of Prescription/OTC Drugs: How Pharmacist Can Prevent and Manage Drug Abuse
Mohammed Mustafa G, C Chandana
pp. s167–s173 · DOI: 10.5530/ijper.57.1s.20 · Published 2023
Background: Drug misuse is a critical issue related to both physical and psychological health associated with growing threats across the world. The role of pharmacist in preventing drug abuse is crucial to address prescr…
Article
Pharmacophore based High Throughput Virtual Screening towards the Discovery of Novel BLK (B-lymphocyte kinase)-tyrosine Kinase Inhibitors
Sana Sumera, Sanjai Srinivasan, Harshitha BV, Sharanagoud Biradar, Shankarrao Patil
pp. s174–s182 · DOI: 10.5530/ijper.57.1s.21 · Published 2023
Aim: LK (B-lymphocyte kinase) is a protein from the family SRC (Proto-oncogene tyrosine-protein kinase), an important cell signaling molecule that influences cellular response. The BLK tyrosine-protein kinase has been a …
Article
Assessment of Adherence and Common Non-adherence Factors for Inhaled Medications in Asthma and Chronic Obstructive Pulmonary Disease (COPD) Patients
Ashita Maria Nazareth, Rohit O Agarwal, Sujit Kumar Sah, Neethu Reji, Minju Biju, Shilpa Palaksha
pp. s183–s188 · DOI: 10.5530/ijper.57.1s.22 · Published 2023
Background: Inhaled medications are the cornerstone for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Adherence of inhaled medications can be influenced by many factors such as patient prefere…