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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Formulation and Evaluation of Aspirin-PLGA Microsphere for the Dental Stem Cell Stimulation

Litha Thomas1,4, Preeti Karwa2★, V Kusum Devi3★ Corresponding author

  1. 1Department of Pharmaceutics, Krupanidhi College of Pharmacy, Bengaluru, Karnataka, INDIA.
  2. 2Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bengaluru, Karnataka, INDIA.
  3. 3Department of Pharmaceutics, NITTE College of Pharmaceutical Sciences, Bengaluru, Karnataka, INDIA.
  4. 4Part-time Research Scholar, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bengaluru, Karnataka, INDIA.

CORRESPONDENCE

Preeti Karwa

Professor and Head of Department, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Nr. Lalbaug Main Gate, Hosur Road, Bangalore - 590027, Karnataka, INDIA.

aacp012018@gmail.com

Received: 18-11-2022; Revised: 28-12-2022; Accepted: 24-02-2023.

Volume 57, Issue 1S · pp. s52–s62 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.1s.7

View on IJPER original site ↗

ABSTRACT

Aim: According to WHO, dental caries is the most prevalent oral disease, and its progression leads to tooth loss. Clinical management of caries focuses on the severity and extent of disease with the main aim, i.e., the ‘art’ of creating a good restoration. Recently, it has been reported that aspirin can stimulate existing stem cells and regenerate damaged teeth. But, the therapeutic effectiveness of a drug depends on developing a suitable novel drug delivery system, to retain at the site and suitably release the drug to produce effective therapy. Therefore, the present investigation intends to develop Aspirin-Poly lactic-co-glycolic acid microspheres for the restoration of dentin. Materials and Methods: Aspirin- Poly lactic-co-glycolic acid microsphere was formulated by the double emulsion technique and evaluated for particle size, encapsulation efficiency, characterization (differential scanning calorimetry, X-ray powder diffraction), in vitro release, as well as irritation testing using the Hen’s egg test-chorioallantoic membrane method. Results: The formulation exhibited good encapsulation efficiency (87.31±1.52%) and a particle size of 7.52 μm by Scaning Electron Micrscopy. In vitro release study exhibited sustained release (98.76±0.49%) for 16 days and triphasic release. This confirms that release is due to polymer erosion, swelling, and degradation. The ex vivo permeation study also confirmed sustained permeation and showed the significant partition and accumulation of the drug in the tissue. Further, the prepared formulation showed significantly low irritation compared to positive control by Hen’s Egg Test-Chorioallantoic Membrane method. Conclusion: Thus, the above finding suggests that the formulation can stimulate stem cells for the regeneration of dental tissue.

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    Thomas, L., Karwa, P., & Devi, V. K. (2023). Formulation and Evaluation of Aspirin-PLGA Microsphere for the Dental Stem Cell Stimulation. Indian Journal of Pharmaceutical Education and Research, 57(1S), s52–s62. https://doi.org/10.5530/ijper.57.1s.7