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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Formulation and Evaluation of Niosomal Gel Loaded with Asparagus racemosus Extract for Anti-inflammatory Activity

Nikhilkumar Yeshwanth Hegdekar1, Sneh Priya1★, Suchith S Shetty1, Divya Jyothi2★ Corresponding author

  1. 1Department of Pharmaceutics, NITTE (Deemed to be University), NGSM Institute of Pharmaceutical Sciences, Deralakatte, Mangalore, Karnataka, INDIA.
  2. 2Department of Pharmacognosy, NITTE (Deemed to be University), NGSM Institute of Pharmaceutical Sciences, Derelakatte, Mangaluru, Karnataka, INDIA.

CORRESPONDENCE

Sneh Priya

Assistant Professor, Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Deralakatte, Mangaluru-575018, Karnataka, INDIA.

snehpriya123@nitte.edu.in

Received: 10-12-2022; Revised: 30-01-2023; Accepted: 22-02-2023.

Volume 57, Issue 1S · pp. s63–s74 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.1s.8

View on IJPER original site ↗

ABSTRACT

Background/Aim: Inflammation typically occurs when infectious microorganisms enter the body, settle in specific tissues, and/or circulate in the blood. Asparagus racemosus extract contains various saponins and flavonoids and plant-origin drugs have fewer side effects and toxicity. The phytoconstituents have less permeability through the skin; to enhance their permeability and effectiveness it was loaded in niosomes. Therefore, the study aimed to formulate and characterize the niosomal gel loaded with Asparagus racemosus extract for anti-inflammatory activity. Materials and Methods: The niosomes containing saponins in the extract were prepared using thin film hydration method and 2³ full factorial design was employed to assess the influence of independent variables span 60 and cholesterol on vesicle size, PDI, zeta potential, and percentage entrapment efficiency. 10% of niosomal and conventional gels were prepared by incorporating optimized niosomes and extract containing total saponin in 1% carbopol gel. Ex vivo permeability studies of prepared gels were performed through goat skin using Franz diffusion cell. An anti-inflammatory study was conducted on albino rat. Results: The statistical analysis revealed the significant effect of independent variables on vesicle size, PDI, entrapment efficiency and zeta potential. SEM image shows vesicles are spherical in shape and uniform in size. The niosomal gel provided a significantly higher amount of steady-state flux and permeability coefficient into the skin than conventional gel. The animal model proved that niosomal gel loaded with total saponins in extract showed significant anti-inflammatory compared to the control. Conclusion: It was concluded that the niosomal gel had better efficacy than the conventional gel.

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    Hegdekar, N. Y., Priya, S., Shetty, S. S., & Jyothi, D. (2023). Formulation and Evaluation of Niosomal Gel Loaded with Asparagus racemosus Extract for Anti-inflammatory Activity. Indian Journal of Pharmaceutical Education and Research, 57(1S), s63–s74. https://doi.org/10.5530/ijper.57.1s.8