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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Binding Study of Monohydroxy Cucurbit[7]uril with Rhodamine B

Karuppasamy Karpagalakshmi, Ramesh Prakash, Usha Govindaraj, Radhakrishnan Sathish Kannan, Lakshminarayanan Piramuthu, Narayanan Selvapalam★★ Corresponding author

  1. 1International Research Center and Department of Chemistry, Kalasalingam Academy of Research and Education (Kalasalingam University), Virudhunagar, Tamil Nadu, INDIA.

CORRESPONDENCE

Narayanan Selvapalam

Center for Supramolecular Chemistry, Kalasalingam Academy of Research and Education, Virudhunagar-626126, Tamil Nadu, INDIA.

n.selvapalam@klu.ac.in

Received: 03-03-2022; Revised: 17-01-2023; Accepted: 31-03-2023.

Volume 57, Issue 3 · pp. 822–826 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.3.100

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ABSTRACT

Background: Cucurbit[7]uril (CB[7]) is the most important host among the reported cucurbit[n]urils family members, because it exhibited unique molecular recognition with exceptional applications. The binding affinity of functionalized CBs, especially mono hydroxylated CB[7] is important, because it will help to understand the difference in binding profile of functionalized CB[7] in comparison to that of the parent CB[7]. Materials and Methods: We have utilized Rhodamine B (RhB) to get encapsulated in monohydroxy CB[7] (CB[7]-OH) and measured the binding affinity of RhB in water. Results: The binding properties showed that the CB[7]-OH and RhB formed a 1:1 host-guest complex and the binding constant was found to be 3.75 × 104 M-1, which is slightly lower than the binding affinity of the parent molecule CB[7], which indicates that the binding behavior of CB[7]-OH not deviated much from the parent CB[7] molecule. Electrostatic Potential studies of these two molecules also supported these results. Conclusion: The binding studies of monohydroxy CB[7] (CB[7]-OH) successfully studied with RhB in water.

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    Karpagalakshmi, K., Prakash, R., Govindaraj, U., Kannan, R. S., Piramuthu, L., & Selvapalam, N. (2023). Binding Study of Monohydroxy Cucurbit[7]uril with Rhodamine B. Indian Journal of Pharmaceutical Education and Research, 57(3), 822–826. https://doi.org/10.5530/ijper.57.3.100