Volume 57, Issue 4

1. Article

   Sustainable Antimicrobial Nanomaterials: A Promising Treatment for Multiple Drug Resistant Microorganisms

   Neha S. Raut, Ram Musle, Monika Raut, Rakesh M. Kanchhul, Ekant S. Taywade, Milind J. Umekar

   pp. 937–950 · DOI: 10.5530/ijper.57.4.115 · 2023

   : Antibacterial drugs had an essential role in the treatment of various diseases from a long-time whereas excess use leads to resistance and toxicity which is a great challenge in the health sector. The most important fa…

   TextPDFLens
2. Article

   Role of Stem Cells in the Management of Type-I Diabetes Mellitus

   H. R. Arjun, Praveen Halagali, Y. Mohammed Tausi, N. Paramakrishnan, U. R. Rakshith

   pp. 951–955 · 2023

   The paper aims to accent Type-1 DM along with its etiology, pathophysiology, and treatment in this review. Diabetes is considered the chronic ailment of hypoglycemia ensuing from the duo of the dearth of insulin action a…

   TextPDFLens
3. Article

   Biotherapeutic Potential of Lactobacillus Probiotic Strains on Streptococcus mutans Biofilm in Dental Caries-Pathogenesis Revisited

   Vaishnavi Vedam, Sabesan Gokul Shankar, Arun Kumar Adhikary, Subramani Parasuraman

   pp. 956–964 · 2023

   This review gives an insight on the anticariogenic role of each of the individual strains of Lactobacillus probiotics on Streptococcus mutans bacterium associated with dental caries and also attempts to emphasize the com…

   TextPDFLens
4. Article

   Quality by Design based Quercetin Hydrate Nanoemulsions for Enhanced Solubility by Reducing Particle Size

   Lakavath Sunil Kumar, Hindustan Abdul Ahad

   pp. 965–970 · 2023

   Aim/Background: The oral-based drug delivery system has a great pace in this era of novel discoveries. The globe is running toward new medical dosage forms, but from the primer days of drug discovery to now, a major issu…

   TextPDFLens
5. Article

   Mucoadhesive Chitosan-Coated PLGA Nanoparticles of Ashwagandha Extract for Colon-Targeted Delivery

   Abhilash Megaravalli Manjunath, Sneh Priya, Divya Jyothi

   pp. 971–982 · 2023

   Aim/Background: Withania somnifera (Ashwagandha) belongs to the Solanaceae family, well known for its phyto-pharmacological properties such as anti-inflammatory, antioxidant, anti-stress, immunomodulatory, and anticancer…

   TextPDFLens
6. Article

   Central Composite Design Assisted Formulation Development and Optimization of Gastroretentive Floating Tablets of Dextromethorphan Hydrobromide

   Haranath Chinthaginjala, Hindustan Abdul Ahad, Sainath Kethandapatti Srinivasa, Srihith Roy Yaparla, Snehitha Buddadasari, Junaid Abul Hassan, Sai Sree Pullaganti

   pp. 983–992 · 2023

   Objectives: The existing study is concerned with the formulation and optimization of dextromethorphan hydrobromide floating tablets via central composite design. Materials and Methods: Direct compression method was emplo…

   TextPDFLens
7. Article

   Design, Development and Optimization of Buccal Tablet Containing Extract of Terminalia chebula Retz. for the Treatment of Asthma

   P. B. Suruse, M. B. Gawali, R. S. Kalkotwar, R. B. Bhabad, S. B. Bagdane, L. G. Barde

   pp. 993–1001 · 2023

   Objectives: The aim of the study was to design, develop, and optimize the buccal tablets containing extract of Terminalia chebula Retz. for the treatment of asthma. Materials and Methods: Buccal tablets were made using t…

   TextPDFLens
8. Article

   Ameliorating the Poor Dissolution Rate of Selexipag in Aqueous Acidic Conditions Following Confinement into Mesoporous Silica

   Mohamed S. Attia, Fakhr-Eldin S. Ghazy

   pp. 1002–1011 · 2023

   Background: Pulmonary Arterial Hypertension (PAH) is a serious condition with available treatment options, including Selexipag (SXP), a selective prostacyclin receptor agonist that has effectively reduced patient morbidi…

   TextPDFLens
9. Article

   Development, Evaluation, and in vitro Anti-Acne Activity of Tretinoin Nanocrystals Gel

   Pottathil Shinu, Akash Sharma, Anroop B. Nair, Manish Kumar, Shahzad Khan, Abdulaziz K. Al Mouslem, Mohamed A. Morsy, Abhishek Tiwari, Varsha Tiwari, Beena Kumari

   pp. 1012–1020 · 2023

   Background: Tretinoin is generally used to treat acne vulgaris and photoaging. The study aimed to develop a gel composition containing tretinoin nanocrystals and characterize and compare in vitro anti-acne activity. Mate…

   TextPDFLens
10. Article

    Formulation, Characterization, and Cytotoxic Effect of PVA Incorporated Iron Oxide Nanoparticles of Gramine Using HCT-116 Cell Line in vitro

    Ahmed S. Alnaim

    pp. 1021–1028 · 2023

    Background and Objectives: Globally, Colorectal cancer is the major cause of death. The current work emphasizes the synthesis of Gramine-loaded polyvinyl alcohol (PVA) coated Iron Oxide nanoparticles (NPs) and the evalua…

    TextPDFLens
11. Article

    Identifying Potential Drug Candidates against Plasmodium falciparum (Isolate 3D7) through Targeting ADP-dependent DNA Helicase RecQ: An in silico Approach

    Marya Ahsan, Ayaz Khurram Mallick

    pp. 1029–1036 · 2023

    Background: The malarial scenario has significantly varied in the past few decades; whether it is funding or the range of sophisticated life-saving tools that have been improved, the disease burden has reduced, and even …

    TextPDFLens
12. Article

    In vitro and in silico Protective Effects of Ascorbic Acid on Nicotine-treated Human Erythrocytes (Preliminary Studies)

    Ohoud Saeed S Alamri, Uzma Faridi

    pp. 1037–1043 · 2023

    Objectives: Nicotine is one of the most addictive naturally occurring drugs and is commonly found in tobacco products. Tobacco products are one of the most common causes of lung and oral cancer all over the world. As the…

    TextPDFLens
13. Article

    In silico Discovery of STRA 6 Vitamin A Receptor, as a Novel Binding Receptor of COVID-19

    Mahmoud Elkazzaz, Israa M. Shamkh

    pp. 1044–1052 · 2023

    A global pandemic of pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, at the end of 2019. Although, the ACE2 receptor has been demonstrated to be the main entry …

    TextPDFLens
14. Article

    Citrollenol Abrogates Neuroinflammatory Pathway Regulated via Induction of NF-kB in AlCl3 Induced Alzheimer’s Disease – Molecular Approach

    Xiaoli Zhou, Hesham S. Almoallim, Balasubramani Ravindran, Rui Qin

    pp. 1053–1060 · 2023

    Background: Alzheimer's Disease (AD), a neurodegenerative disorder characterized by dementia, is linked to ROS-induced stress, neuroinflammation, and gut microbiota imbalance. Objectives: The antioxidant and anti-inflamm…

    TextPDFLens
15. Article

    Neuroprotective Effect of Ruscogenin against Cognitive Impairment on Pentylenetetrazole-induced Epileptic Seizures in Rats

    Qiaoli Ma, Hesham S. Almoallim, Sulaiman Ali Alharbi, Thamaraiselvan Rengarajan

    pp. 1061–1070 · 2023

    Background: Epilepsy, which affects about 1% of the world's population, is the third most common neurological disease after stroke and Alzheimer's disease. It is characterized by recurrent spontaneous seizures due to abn…

    TextPDFLens

Original Article

1. Article

   Evaluation of the Aqueous Extract of Musa acuminata Corm (Rhizome) for its Anti-diabetic Potential in Streptozotocin (STZ) Induced Diabetic Zebrafish (Danio rerio) Model

   Yahia Ali Kaabi

   pp. 1071–1077 · DOI: 10.5530/ijper.57.4.129 · 2023

   Background Information: Diabetes Mellitus (DM) is spiking substantially in both emerging and developed countries and the use of a nutritional approach to diabetes control has recently attracted a lot of attention. The ba…

   TextPDFLens
2. Article

   Influence of Extraction Techniques on Betalain Yield and Bioactive Phytochemical Analysis of Nopal Fruit Peels

   Anbarasi Karunanithi

   pp. 1078–1086 · DOI: 10.5530/ijper.57.4.130 · 2023

   Background: Nopal fruits (Opuntia ficus-indica) and their peels contain significant amount of natural colorants which can be used in food and pharmaceutical applications instead of using synthetic dyes. Materials and Met…

   TextPDFLens
3. Article

   Palliative Action of Woodfordia fruticosa Leaves Containing Woodfruticosin on Biological Redox Imbalance and Anemia in CFA-Induced Arthritic Rats

   Ashish Singhai, Yusra Ahmad, Umesh Kumar Patil

   pp. 1087–1097 · DOI: 10.5530/ijper.57.4.131 · 2023

   Background: Rheumatoid Arthritis (RA) is a chronic disorder affecting musculoskeletal and autoimmune system with inflammatory characteristics. Anemia is most prevailing, among other extra-articular complications in RA. T…

   TextPDFLens
4. Article

   Phytochemical Screening, Acute Toxicity Study, and Pharmacological Evaluation of Natsiatum herpeticum Buch.Ham. ex Arn.

   Sangeeta Hazarika, Siva Hemalatha, Katharigatta Narayanaswamy Venugopala

   pp. 1098–1103 · DOI: 10.5530/ijper.57.4.132 · 2023

   Background: Plants are an open treasure of diverse pharmacologically active scaffolds. Natsiatum herpeticum, a least exploited plant, is known to be consumed by various ethnic groups of Asian origin as edible or as part …

   TextPDFLens
5. Article

   Evaluation of Sinapic Acid on STZ-induced Depression in Diabetic Wistar Rats

   Shubhangi Pawar, Sheetal Shinde, Ekta Khapare, Rishikesh Bacchav

   pp. 1104–1111 · DOI: 10.5530/ijper.57.4.133 · 2023

   Objectives: Presently, diabetes is a major chronic metabolic abnormality characterized by sustained hyperglycemia. Diabetic neuropathy, encephalopathy, diabetes induced anxiety, depression is common life-threatening comp…

   TextPDFLens