Volume 58, Issue 2

Original Article(continued)

1. Article

   Therapeutic Potential of Withania somnifera on Nandrolone Decanoate Induced Gonadal Toxicity

   Sugumaran Sivanandam, Sivanesan Senthilkumar, Boopalan Dipti, Ravishankar Priyadarsini Subashree, Vinod Visakha, Parthiban Praveenkumar

   pp. 555–564 · DOI: 10.5530/ijper.58.2.62 · 2024

   Background: Nandrolone decanoate (ND) is a commonly used androgen-based steroid that causes adverse effects on illicit self-administered users to boost their physical endurance. Although, it has an anabolic effect on the…

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2. Article

   Green Synthesis and Characterization of Silver Nanoparticles from Nerium indicum and Investigation of Antioxidant and Anti-Cancerous Potential against Cervical Cancer Cell Line (HeLa)

   Rutuja Kini, Rashmi Trivedi, Mohd Hasan Mujahid, Pratikshya Patra, S. A. Alharbi, F. D. Alshammari, M. M. Babikir Bealy, A. E. O. Elkhalifa, Samra Siddiqui, Tarun Kumar Upadhyay

   pp. 565–578 · DOI: 10.5530/ijper.58.2.63 · 2024

   Background: Nanotechnology has introduced innovative approaches to clinical applications and drug delivery systems, and among the various nano-materials, AgNPs have garnered significant attention due to their biocompatib…

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3. Article

   Formulation and Optimization of Aripiprazole-Loaded Nanostructured Lipid Carriers for Nose-to-Brain Delivery

   Layla Albaqshi, Amanjot Singh, Shahzad Khan, Manish Kumar, Jagpreet Kour, Shinu Pottathil, Bandar Aldhubiab, Abhishek Tiwari, Anroop B Nair

   pp. 579–588 · DOI: 10.5530/ijper.58.2.64 · 2024

   Background: Low bioavailability, highly variable blood levels and poor clinical efficacy of Aripiprazole (ARP) are primarily linked to its hydrophobic nature. This investigation focused on the formulation of ARP loaded N…

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4. Article

   TGF-β2-modulating Anti-apoptosis Effect of Osteoblasts by Sodium Fluoride

   Jitao Yang, Jialu Liu, Xuyang Xie, Qiang Deng

   pp. 589–594 · DOI: 10.5530/ijper.58.2.65 · 2024

   Objectives: This study aimed to investigate and discuss the mechanism of fluoride-induced osteoblast apoptosis in TGF-β2 signaling pathway. Materials and Methods: The osteoblasts were divided into 0 (control group), 5.0,…

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5. Article

   Ameliorative Effect of Cichoric Acid against Diabetes Associated Cognitive Decline with Emphasis on Neurobehavioral Activity, Aβ and AChE

   Sunil Shukla, Sunil Sharma, Neeru Vasudeva, Tanuj Hooda

   pp. 595–602 · DOI: 10.5530/ijper.58.2.66 · 2024

   Background: Diabetes Mellitus (DM) is closely related to degenerative and functional abnormalities of the CNS. Studies indicate that an alteration in the CNS brought on by persistent hyperglycemia is primarily responsibl…

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6. Article

   Influence of Cirsimaritin on Anticancer Activity against HCT-116 Cell Line

   Mohammed Ageeli Hakami

   pp. 603–609 · DOI: 10.5530/ijper.58.2.67 · 2024

   Background: Statistics show colon cancer is the third most severe cancer type worldwide. It was discovered that there is a very high death and morbidity rate. Along with breast, prostate, lung, and colon cancer is one of…

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7. Article

   In vitro and in silico Investigations on the Anti-cancer Efficacy of Eupatorin, a Polymethoxy Flavone against Ovarian Cancer PA-1 Cell Line

   Nizar A. Khamjan, Ahmed Ali Jerah, Mahmoud M Habibullah, Abdullah Farasani

   pp. 610–617 · DOI: 10.5530/ijper.58.2.68 · 2024

   Background: Ovarian cancer is a prominent contributor to cancer-related death among women residing in developed countries. The most of instances are discovered when the cancer has already developed, which results in dism…

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8. Article

   Nephroprotective Activity of Dibenzo-α-Pyrone Derivatives in Gentamicin-Induced Nephrotoxicity and Oxidative Stress in Rats

   Shalini K. Sawhney, Monika Singh, Dinesh Puri, Sangeeta Hazarika, Achal Mishra

   pp. 618–623 · DOI: 10.5530/ijper.58.2.69 · 2024

   Objectives: The current work was done to determine the curative and nephroprotective activities of the synthesized butylamine derivative of Dibenzo-α-Pyrone (DAP). Materials and Methods: The synthesised drug at a concent…

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9. Article

   Design, Synthesis, Anticancer Activities and Comparative Molecular Docking Studies of a Novel Class of 7-Azaindole Analogs as Potent PARP-1 Inhibitors

   Neha Sharma, Anurag Chaudhary, Monika Sachdeva

   pp. 624–636 · DOI: 10.5530/ijper.58.2.70 · 2024

   Background: In a research facility, 7-azaindole derivatives were designed and synthesized, and each substance was examined for its capacity to inhibit cancer growth. In the present study, the synthesized analogues were d…

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10. Article

    Novel Substituted-dene-2-(-1,3-Diphenylallylidene) Hydrazine: Design, Synthesis, and in vitro Microbial Assessment

    P. Parthiban, A. Saravanakumar, S. Mohanraj, M. C. Kavinkumar, S. Sangeetha, M. Loganathan, N. Vivekanandan, M. Abbinanthan, P. Bharat, M. Santhosh, M. Muthuraj, B. Lakshminarayanan

    pp. 637–641 · DOI: 10.5530/ijper.58.2.71 · 2024

    Background: The production of a variety of chalcones (1-Aryl/Alkyl amino substituted-dene-2- (-1,3-diphenylallylidene) hydrazine (ABSa-e) was brought about as a result of the condensation of hydrazide compound and Aryl/A…

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11. Article

    Isolation and Analysis of Phanera variegata Mucilage by Various Analytical Techniques

    Keshav Bansal, Meenakshi Bajpai

    pp. 642–650 · DOI: 10.5530/ijper.58.2.72 · 2024

    Objectives: The objective of the present study was to isolate mucilage from the leaves of Phanera variegata L., to do the thermal, microscopic, elemental analysis, and physicochemical characterization of isolated mucilag…

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12. Article

    Exploring Analytical Quality by Design (AQbD) Enabled RP-HPLC Method for Carvedilol

    Krantisinha Hanumant Randive, Meenaxi Maruti Maste, Amolkumar Ashok Kempwade

    pp. 651–660 · DOI: 10.5530/ijper.58.2.73 · 2024

    Background: Carvedilol (CDL) is a beta-blocker that helps to lower the risk of heart attack related mortality and is used to treat congestive heart failure and excessive blood pressure. Objectives: The present study deal…

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13. Article

    Assessment of Factors Associated with Generalized Anxiety Disorder and Psychological Distress amid COVID-19 Pandemic: Cross-Sectional Study on the Students of Ras Al Khaimah Medical and Health Sciences University

    Bhoomendra Bhongade, Areeg Anwer Ali, Shukri Adam

    pp. 661–670 · DOI: 10.5530/ijper.58.2.74 · 2024

    Background: Worldwide, the COVID-19 pandemic has caused higher levels of anxiety and psychological distress among university students. To effectively implement interventions in the UAE setting, it is crucial to have an a…

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14. Article

    Emotional Intelligence and Perceived Stress in Pharmacists Completing Post-Graduate Specialization Programs: A Cross-Sectional Study

    Dejan Sen anski, Valentina Marinkovi, Andrijana Milo evi Georgiev, Ivana Tadi

    pp. 671–678 · DOI: 10.5530/ijper.58.2.75 · 2024

    Background: Emotional Intelligence (EI) has been recognized by the International Pharmaceutical Federation as a required competency for a pharmacist. This study aimed to compare EI and Perceived Stress (PS) levels in pha…

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15. Article

    Comparative Adsorption of Methyl Orange Color from an Aqueous Solution Using Activated Carbon

    Samer S. Abu Al-Rub, Bandar A. Alyami, Yahya S. Alqahtani, Alhassan R. Alqarih, Bader A. Dunquwah, Mabar M. Alyami, Saleh K. Alghithan, Hamad H. Alsalah, Aya S. Aburub

    pp. 679–684 · DOI: 10.5530/ijper.58.2.76 · 2024

    Background and Aim:The study was focused on the adsorption parameters of Methyl Orange dye (MO) onto Commercial Activated Carbon (CAC) in aqueous solution. The examined of parameters in the adsorption process were founde…

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16. Article

    Diosmetin, Methylated Flavonoid Mitigates Ovalbumin Induced Allergic Rhinitis in Mice by Attenuating Inflammatory Signaling Proteins

    Jia Yu, Yuanyuan Xu

    pp. 685–694 · DOI: 10.5530/ijper.58.2.77 · 2024

    Background: Allergic Rhinitis (AR) is a chronic disorder that affects about 15-20% of the global population. In severe cases, AR causes sleep deprivation and impairs work performance and quality of life. Untreated allerg…

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