Volume 58, Issue 2

Pitchai Balakumar, Renukha Sellappans, Murugan Thangiah, Kumaran Shanmugam, P.K. Srividhya, Gowraganahalli Jagadeesh

pp. 370–376 · DOI: 10.5530/ijper.58.2.42 · 2024

It was generally believed that the most significant part of academic faculties’ work was teaching students, thus they devoted their all-time to the teaching-learning process. The basic requirements to become a faculty ar…

Anuradha Parixit Prajapati, Shivani Gandhi, Garima Singh, Sachin Narkhede, Shailesh Luhar

pp. 377–385 · DOI: 10.5530/ijper.58.2.43 · 2024

Mosquito-borne diseases pose significant public health threats worldwide, necessitating effective prevention strategies. Traditional chemical agents used for mosquito bite prevention often carry environmental and health …

Dyandevi Mathure, Dileep Kumar, Hemantkumar Ranpise, Rajendra Awasthi

pp. 386–400 · DOI: 10.5530/ijper.58.2.44 · 2024

Astrocytes are the most abundant cells in the brain. Astrocytes take part in the absorption and recycling of neurotransmitters, inflammation, neuroenergetics, the release of gliotransmitters, the regulation of synaptic a…

Shravanthi Ravula, Sravani Akula, Rama Krishna Kancha

pp. 401–410 · DOI: 10.5530/ijper.58.2.45 · 2024

The heat shock protein 90 (HSP90) plays a crucial role in regulating cellular homeostasis. Importantly, enhanced dependence of cancer-specific proteins or mutants on HSP90 for their stability and activity offers HSP90 as…

Yulin Zhang, Jia Liu, Wei Xu, Qin Kong

pp. 411–416 · DOI: 10.5530/ijper.58.2.46 · 2024

Aim/Background: The transformation of the “new medical education” model imposes higher demands on universities and educators, representing the latest requirements for the development of medical education. In the past dec…

Phaneendra Kurapati, Santhivardhan Chinni

pp. 417–431 · DOI: 10.5530/ijper.58.2.47 · 2024

Background: The current research work was aimed to optimize and develop Pulsatile Drug Delivery Systems (PDDS) of esomeprazole so as to control the nocturnal acid breakthrough in ulcer patients. Materials and Methods: Mi…

Dipti Gohil, Miten Shah, Nirmal Shah, Rajesh A. Maheshwari

pp. 432–440 · DOI: 10.5530/ijper.58.2.48 · 2024

Background: Rheumatoid Arthritis is an Autoimmune disease, can be categorized by painful joints with limited treatment option. An Oral administration of Leflunomide for longer duration might lead to the Liver Toxicity. H…

Avinash Hanmant Hosmani, Nikhil Dilip Patil, Arti Achut Pawar, Sandip Mohan Honmane, Yogesh Shripad Thorat

pp. 446–452 · DOI: 10.5530/ijper.58.2.50 · 2024

Objectives: The current work aimed to prepare and characterize Surface-Solid Dispersion (SSD) of Fenofibrate (FNB) in order to improve its solubility and dissolution. Materials and Methods: SSD of FNB has been prepared u…

Sandeep Ghangas, Praveen Kumar Ashok, Tanuj Hooda

pp. 453–459 · DOI: 10.5530/ijper.58.2.51 · 2024

Aim: Isotretinoin (ISTN) is a retinoid analogue and known as 13-cis retinoic acid. It is approved for the treatment of Acne vulgaris. Research work was done to improve bioavailability of Isotretinoin by preparing solid l…

Shaanya Johl, Sayani Bhattacharyya

pp. 460–469 · DOI: 10.5530/ijper.58.2.52 · 2024

Aim/Background: According to estimates, about a billion people in the world have fungal infections of the skin, nails, and hair. Skin disorders are a significant contributor to disability, deformity, and misery among peo…

Nagaraja Sreeharsha, Sandhyanjali Cherukuri, Nimbagal Raghavendra Naveen, Prakash Goudanavar, Santosh Fattepur, Bandar Aldhubiab, Rashed M Almuqbil, Anroop B Nair

pp. 470–479 · DOI: 10.5530/ijper.58.2.41 · 2024

Background: To assess the potential for targeting the brain through intranasal delivery, this study focuses on optimizing and developing a mucoadhesive in situ gel formulation containing Dolutegravir nanoparticles. Mater…

Swati R. Dhande, Jayashree Mahadik, Archana R. Gujja

pp. 480–486 · DOI: 10.5530/ijper.58.2.53 · 2024

Introduction: Arjuna is used for its cardioprotective action while Aloe vera is herbal dietary supplement. Isoproterenol hydrochloride was administered subcutaneously to rats to induce myocardial infarction. Objectives: …

Dhanunjaya Sandopa, Chitra Vellapandian

pp. 487–495 · DOI: 10.5530/ijper.58.2.54 · 2024

Background: The traditional plant Decalepis hamiltonii, indigenous to southern India, is a key component in the well-known herbal beverage nannari. It has also been utilised as a general vitalizer and paediatric rejuvena…

Lekha Mathew, Ramalingam Suresh, Ammanath Anil Babu

pp. 496–502 · DOI: 10.5530/ijper.58.2.55 · 2024

Background: The phytochemical evaluation of the ethanolic extract of the plant, Gymnostachyum febrifugum Benth. (Acanthaceae family) was carried out to evaluate its therapeutic potential. Despite being part of traditiona…

Sunil Shukla, Sunil Sharma, Neeru Vasudeva, Tanuj Hooda

pp. 503–509 · DOI: 10.5530/ijper.58.2.56 · 2024

Background: Evidences suggest that the development of neurodegenerative dementia is accelerated by Diabetes Mellitus (DM), a chronic metabolic condition. In Diabetes Mellitus (DM), improper glucose metabolism produces gl…

Ziyad M. Althafar

pp. 510–518 · DOI: 10.5530/ijper.58.2.57 · 2024

Background and Aim:One of the most prevalent cancers worldwide is lung cancer with the second top fatality rate. The purpose of this work is to disclose the anti-proliferative ability of hydroalcoholicFicus benghalensis …

Sachin N. Kapse, Vaibhav G. Bhamare, Rakesh D. Amrutkar, Rahul N. Patil, Vinod R. Patil, Gokul S. Talele

pp. 519–525 · DOI: 10.5530/ijper.58.2.58 · 2024

Background: Mammary cancer is the most common type of cancer and the leading cause of cancer-related death in women. Despite of numerous therapeutic options, cancer remains associated with high mortality. Traditional her…

Mohd Saeed, Munazzah Tasleem, Samra Siddiqui, Tarun Kumar Upadhyay, Tulika Bhardwaj, Md Jahoor Alam, Saad Saeed Alqathani, Fevzi Bardakci, Nujud Almuzaini, Rania Abdeen Hussain Abdalla, Ambreen Shoaib

pp. 526–534 · DOI: 10.5530/ijper.58.2.59 · 2024

Caspase-3 regulates apoptosis, and its deregulation in Non-Small Cell-Lung Carcinoma (NSCLC), and contributes to tumour growth and therapeutic resistance. Significant resistance to chemotherapy and radiation therapy, whi…

Chandrasekaran Ponnusamy, V. V. Sathibabu Uddandrao, Vadivukkarasi Sasikumar, Puniethaa Prabhu, Saravanan Ganapathy

pp. 535–545 · DOI: 10.5530/ijper.58.2.60 · 2024

Background: Therapeutic products obtained from nature have been gaining attention for health improvement, disease treatment, and drug development. Traditional therapeutic compounds from plants, animals, and microorganism…

Yogesh Mahadeo Amgaonkar, Nitin Indarchand Kochar, Anil Vishwanath Chandewar, Milind Janrao Umekar, Kamlesh Jayantilal Wadher

pp. 546–554 · DOI: 10.5530/ijper.58.2.61 · 2024

Background: Topical delivery of medication is often considered to be the best choice due to benefits such as avoidance of gastric degradation, first pass metabolism along with effortless application and retrieval. In top…