jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Acetyl-11-Keto-β-Boswellic Acid-Loaded Ethosomes as Nanocarriers from a Physicochemical Perspective and in vivo Evaluation

Daphisha Marbaniang1, Niva Rani Gogoi1, Paulami Pal1, Anup Kumar Das2, Bani Kumar Jana1, Ananta Saikia3, Bhaskar Mazumder★★ Corresponding author

  1. 1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, INDIA.
  2. 2Department of Pharmaceutical Sciences, Assam University, Silchar, Assam, INDIA.
  3. 3Department of Pharmaceutical Sciences, Pratiksha Institute of Pharmaceutical Sciences, Panikhaiti, Assam, INDIA.

CORRESPONDENCE

Bhaskar Mazumder

Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, INDIA.

bhmaz@dibru.ac.in

Received: 19-06-2023; Revised: 16-11-2023; Accepted: 26-06-2024.

Volume 59, Issue 1 · pp. 82–93 · PUBLISHED Jul-Sep 2024 · DOI: 10.5530/ijper.20254420

View on IJPER original site ↗

ABSTRACT

Background Ethosomes are elastic nanovesicles made of phospholipids that contain a high concentration of ethanol. It has shown to improve the skin permeability of many drugs due to interactions between the high ethanol. Materials and Methods The optimization and characterization of 3-Acetyl-11-Keto-β-Boswellic Acid (AKBA) loaded vesicular ethosomes included measurements of particle size, entrapment effectiveness, microscopy using SEM and TEM, and the interaction of the drug and excipients using Fourier transform infrared spectroscopy was carried out. FT-IR studies revealed no interaction between the drug and the excipients. Additionally, in vitro drug permeation test utilizing pig ear skin was conducted on ethosomal formulations. E8 (containing 30% alcohol, 2% w/w phospholipid), was chosen for additional skin permeation studies due to its high percentage of drug entrapment (88.43%) and small particle size (129.3±0.75nm). Results The formulation E8 had the greatest amount of drug permeability (73.22%). Furthermore, paw oedema assay using carrageenan induction was used to investigate the in vivo evaluation of the produced formulation. The anti-inflammatory efficiency of ethosomal vesicles containing AKBA was compared to that of AKBA-loaded carbopol gel. Conclusion It revealed that ethosomal had higher anti-inflammatory activity than carbopol gel formulation. Our findings suggest that the developed ethosomal system has the potential to deliver AKBA through the skin.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Marbaniang, D., Gogoi, N. R., Pal, P., Das, A. K., Jana, B. K., Saikia, A., & Mazumder, B. (2024). Acetyl-11-Keto-β-Boswellic Acid-Loaded Ethosomes as Nanocarriers from a Physicochemical Perspective and in vivo Evaluation. Indian Journal of Pharmaceutical Education and Research, 59(1), 82–93. https://doi.org/10.5530/ijper.20254420