Volume 59, Issue 1

2025 · pp. 1–406 · 40 articles

Volume: 59
Issue: 1
Published: 2025
Pages: 1–406
Articles: 40
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
Elucidating Potential of Dietary PUFAs (Ω-3) In Tackling Cytokine Storm Syndrome by Attenuation of Pro-Inflammatory Cytokines
Faris F. Aba Alkhayl
pp. 1–12 · DOI: 10.5530/ijper.20257024 · Published Jan-Mar 2025
Background The study aims to examines PUFAs precisely ω-3 potential in tackling Cytokine storm syndrome. Study also investigates PUFAs: ω-3 in regulation of pro-inflammatory and anti-inflammatory cytokines associated wit…
Review
An Insight into the Synthetic Strategies and Pharmacological Effects of Cinnoline Derivatives
Shagun Saxena, Rakhi Mishra, Avijit Mazumder, Rupa Mazumder, Mohd Shuaib
pp. 13–29 · DOI: 10.5530/ijper.20253735 · Published Jan-Mar 2025
Background The cinnoline ring is a new aromatic heterocyclic connected with two nitrogen atoms in a 6 membered ring and compounds containing this ring have been shown to have a wide variety of pharmacologicaleffects. Obj…
Review
Laser Induced Breakdown Spectroscopy: A Promising Analytical Technique
Preeti Mehta, Vaishnavi Populwar, Nilima Shinde, Dattatray Dhebe, Pratik More
pp. 30–36 · DOI: 10.5530/ijper.20254665 · Published Jan-Mar 2025
Laser Induced Breakdown Spectroscopy (LIBS) is a rapid analytical technique. It has become an established analytical atomic spectrometry technique for the analysis of various samples. This method is widely used for deter…
Review
Next-Gen Post-Diagnostic Care through Centralized AI and Smart Wearable Devices for Chronic Disease Management: A Narrative Review
Gokul Kumar, Prasanna Kumar
pp. 37–45 · DOI: 10.5530/ijper.20250207 · Published Jan-Mar 2025
This article presents a futuristic framework for incorporating centralized AI to revolutionize patient care, focusing on the post-diagnostic care andmanagement of various chronic conditions.Through the integration of cen…
Review
Heralding a New Era for Higher Education Institutes: Moving Towards Implementation of National Education Policy 2020: A Pharmacy Undergraduate Program Perspective
Archana Upadhya, Madhusudan Natvarlal Saraf
pp. 46–55 · DOI: 10.5530/ijper.20250760 · Published 2025
The National Education Policy (NEP) 2020 has been drafted to bring about a paradigm shift in the prevailing system of education at the school and higher educational levels (Undergraduate and Post graduate Degree programs…

Original Article

Article
Research on the Application of the “BOPPPS+Blended Teaching” Model in a “Food Biochemistry” Course
Li Hu, Yuanxin Li, Dahong Li
pp. 56–64 · DOI: 10.5530/ijper.20253755 · Published Jan-Mar 2025
Background Massive Online Open Course (MOOC) provides a new research idea and direction for educational reform with the internet era. The authors designed a “BOPPPS+blended teaching” model and carried out the practice in…
Article
Fabrication and Evaluation of Floating Zidovudine Microbeads for Prolonged Kinetic Release and Bioavailability
Kiran Dobhal, Shalu Verma, Alka Singh, Gauree Kukreti
pp. 65–73 · DOI: 10.5530/ijper.20254139 · Published Jan-Mar 2025
Aim AIDS (Acquired Immuno Deficiency Syndrome) is one of the most sexually transmitted diseases with chronic depletion of immunity in the body associated with social stigma, social isolation and depression. Zidovudine is…
Article
Design and Characterization of Herbal Transdermal Patch Containing Capsaicin Extract and Mustard Oil for Arthritis
Arpitha Jayatheertha Lokapur, Vedamurthy Joshi
pp. 74–81 · DOI: 10.5530/ijper.20255973 · Published Jan-Mar 2025
Introduction Arthritis, a chronic inflammatory condition causing significant pain and diminished quality of life, affects millions worldwide. This study aimed to develop and characterize a novel herbal transdermal patch …
Article
Acetyl-11-Keto-β-Boswellic Acid-Loaded Ethosomes as Nanocarriers from a Physicochemical Perspective and in vivo Evaluation
Daphisha Marbaniang, Niva Rani Gogoi, Paulami Pal, Anup Kumar Das, Bani Kumar Jana, Ananta Saikia, Bhaskar Mazumder
pp. 82–93 · DOI: 10.5530/ijper.20254420 · Published Jul-Sep 2024
Background Ethosomes are elastic nanovesicles made of phospholipids that contain a high concentration of ethanol. It has shown to improve the skin permeability of many drugs due to interactions between the high ethanol. …
Article
Development and Validation of a High-Performance Liquid Chromatographic Method for Content Assay of Ceftriaxone in Pharmaceutical Dosage
Basavaraj Hiremath
pp. 94–100 · DOI: 10.5530/ijper.20255575 · Published Jan-Mar 2025
Aim A sensitive and accurate RP-HPLC method was developed and validated for the quantitative measurement of Ceftriaxone sodium (CEF) in pharmaceutical dosage forms and bulk medicine. Materials and Methods Ceftriaxone sod…
Article
Assessing the Pharmacological Potential of Thymoquinone for Managing Alcohol Craving and Withdrawal Syndrome in Mice
Mohammad Arsalan Sarmad, Muttavarapu Venkata Ramana, Navneet Khurana
pp. 101–111 · DOI: 10.5530/ijper.20250194 · Published Jan-Mar 2025
Aim/Background The aim is to evaluate THMQ’s impact on alcohol withdrawal and alcohol craving using an animal model. Mice were exposed to increasing ethanol doses to simulate dependency. Researchers assessed anxiety leve…
Article
Punicalagin Inhibits Cell Growth and Promotes Apoptosis in Bladder Cancer T24 Cells via Upregulating Oxidative Stress and Apoptotic Marker Expressions
Junqing Gu, Tao Cai, Yugen Li, Bo Liao
pp. 112–121 · DOI: 10.5530/ijper.20257390 · Published Jan-Mar 2025
Background Bladder cancer is a prevalent form of cancer worldwide and is associated with increased rates of mortality. Objectives The present investigation focuses on understanding the inhibitory activities of punicalagi…
Article
A Comprehensive QbD Study on Bioadhesive Ocular Films for Improved Conjunctivitis Management: Insights from Design Expert Software
Repollu Maddileti, Haranath Chinthaginjala
pp. 122–133 · DOI: 10.5530/ijper.20255680 · Published Jan-Mar 2025
Objectives The study aimed to develop ocular films containing levofloxacin to treat conjunctivitis. These films were meticulously prepared using a combination of Gelatin, Aloe barbadensis leaves mucilage, and HPMC K4M, b…
Article
Mitigation of Insulin Resistance, Inflammation, Oxidative Stress, and Metabolic Abnormalities by Bavachalcone in High-Fat/High-Fructose Diet-Fed Rats
Jintang Yin
pp. 134–143 · DOI: 10.5530/ijper.20257230 · Published Jan-Mar 2025
Background Obesity is defined by an excess of body fat, together with insulin resistance and dyslipidemia. These factors significantly elevate the risk of acquiring chronic disorders such as Diabetes Mellitus (DM), cardi…
Article
Protective Effects of Lysergol against Complete Freund Adjuvant-Induced Rheumatoid Arthritis in Rats
Lian Wang, Li Yan Ma, Yu Ting Yue, Ling Ling Xu, Jian Ming Lai
pp. 144–152 · DOI: 10.5530/ijper.20250039 · Published Jan-Mar 2025
Background Rheumatoid Arthritis (RA) is a rapidly developing autoimmune disease caused by self-destruction of the immune system, resulting in deformed joints and erosion of the bones. In the current study, we explored th…
Article
Therapeutic Potential of Plant Based HMG CoA Reductase Inhibitor-Berberine for Alzheimer’s Disease in ICV Induced Streptozotocin Rodent Model
Y. Mohammed Tausif, Thummuru Ekshita Sai, Rahul Kinnarahalli Rajashekarappa, Dithu Thekkekkara, Vaishnavi Jahagirdar, S.K Meheronnisha, G. HariPriya, Amrita Babu
pp. 153–163 · DOI: 10.5530/ijper.20255856 · Published Jan-Mar 2025
Background Alzheimer's Disease (AD), is a progressive neurodegenerative disease, that results in memory loss, cognitive impairment and behavioral abnormalities. It is one of the most widely spread diseases and is common …
Article
Mir-142-5p Suppresses Ovarian Cancer Metastasis by Inhibiting the Epithelial-Mesenchymal Transition via DNMT1
Qian Qiu, Huan Yi, Jianrong Song, Hui Zheng, Xiangqin Zheng
pp. 164–174 · DOI: 10.5530/ijper.20251283 · Published Oct-Dec 2024
Aim/Background Ovarian Cancer (OC) accounts for the highest number of deaths among gynecological cancers. Our research is focused on investigating the therapeutic potential and the fundamental mechanism by which miR-142-…
Article
Spectral Characterization, Antioxidant and Antibacterial Activities of Cold Methanolic Extract of Sweet Basil (Ocimum basilicum L.) Leaves Growing in Jazan, Kingdom of Saudi Arabia
Md Shamsher Alam, Mohammed Albratty, Hassan Ahmed Hassan Ahmed, Asim Najmi, Khalid Zoghebi, Zia ur Rehman, Vinod Kumar Basode, Sivakumar S. Moni, Mohammad Firoz Alam, Waquar Ahsan, Benson Mathai Kochikuzhyil
pp. 175–184 · DOI: 10.5530/ijper.20250719 · Published Oct-Dec 2024
Background This study evaluated the chemical composition, antioxidant activity and antibacterial properties of methanol extracts of Ocimum basilicum L. leaves that were gathered from the Kingdom of Saudi Arabia’s Jazan p…
Article
Propofol Inhibits Oxidative Stress-Induced Neuronal Cell Ferroptosis and Promotes Synaptic Plasticity via the AMPK/ SIRT1/PGC-1α Axis
Rongmin Chen, Miao Zhang, Liangce Lv, Ruqiu Yin
pp. 185–195 · DOI: 10.5530/ijper.20250931 · Published Oct-Dec 2024
Aim/Background Propofol, recognized for its quick and effective action as a hypnotic anesthetic, is frequently utilized in clinical practice. Our research intended to investigate the mechanism by which propofol inhibits …
Article
Expression of Helicobacter pylori CagA in Solanum melongena L-A Cost Effective Strategy for Vaccine Development
Mohammad Javad Mehran, Rambod Barzigar, Basaralu Yadurappa Sathish Kumar, Nanjundappa Haraprasad, Bashasab Fakrudin, Sayan Paul, Sudhakar Malla, Mansoor Bolideei
pp. 196–209 · DOI: 10.5530/ijper.20250081 · Published Jan-Mar 2025
Background Helicobacter pylori is implicated in several severe gastrointestinal disorders, including gastric cancer, affecting a significant global population. This study aims to exploit plant biotechnology for vaccine d…
Article
Peiminine Alleviates Breast Carcinoma via Reprogramming the PI3K/Akt/mTOR Pathway in vitro and in vivo
Wenming Zhao, Jirui Sun, Binjuan Zhou, Haizhi Qiao, Jinmei Li, Shuangqiu Ma, Jinku Zhang
pp. 210–220 · DOI: 10.5530/ijper.20255151 · Published Oct-Dec 2024
Background The breast cancer is most frequently diagnosed cancer in the women worldwide. Our study investigated the anticancer effect of peiminine, an alkaloid obtained from Fritillaria thunbergii, against breast carcino…
Article
Anticancer, Apoptotic, Cell Migration and Invasion Inhibition and in silico Molecular Docking Studies of Naringetol in A-549 Human Lung Cancer Cells
Jing Li, Beishou Wu, Xuejun Huang, Weizhong Tang
pp. 221–229 · DOI: 10.5530/ijper.20250091 · Published Jan-Mar 2025
Aims The main objective of this research work was to investigate the anticancer effects of Naringetol in A-549 human lung cancer cells along with evaluating its effects on cell apoptosis, cell migration and cell invasion…
Article
Enhancing Therapeutic Potential: Investigating Traditional Detoxification Methods and Assessing their Influence on Anti-Microbial Efficacy, Phytochemical Composition, Heavy Metal Content and Anti-inflammatory Properties in Trachyspermum ammi
Kalkatanur Ganesan Vanitha, N. Anandakumar Natarajan, Natesan Sudhakar, Abdurahman Hajinur Hirad, Abdullah A. Alarfaj, Palanisamy Arulselvan, Rathinam Raja
pp. 230–241 · DOI: 10.5530/ijper.20250286 · Published Oct-Dec 2024
Background Trachyspermum ammi (T. ammi) holds a longstanding position in traditional medicinal practices, renowned for its diverse medicinal and pharmacological attributes. Medicinal plants not only offer significant the…
Article
Apocynin Induces Apoptosis in Human Lung Cancer A549 Cells via Regulating Apoptotic Protein and Inflammatory Cytokines
Li Shang, Jindao Wang, Xiaoqing Liu
pp. 242–251 · DOI: 10.5530/ijper.20250045 · Published Jan-Mar 2025
Objectives Lung cancer, widely considered the leading cause of cancer-related deaths worldwide, ranks fourth in terms of its occurrence among all types of malignant tumors. Phytochemicals are the potent alternative for t…
Article
Evaluation of Antipyretic and Antioxidant Activities of Ten Indigenous Medicinal Plants of Tirtajaya, Karawang Regency, West Java, Indonesia
Neni Sri Gunarti, Maulana Yusuf Alkandahri, Eko Sri Wahyuningsih, Putri Agustina, Iin Lidia Putama Mursal, Himyatul Hidayah, Vera Nurviana
pp. 252–263 · DOI: 10.5530/ijper.20256381 · Published Jan-Mar 2025
Aim This research aimed to explore the antipyretic and antioxidant activity of infusions of Chromolaena odorata (COI), Abelmoschus manihot (AMI), Annona muricata (AMCI), Allium ascalonicum (AAI), Carica papaya (CPI), Tam…
Article
Anti-Atherosclerotic Potency of Lichen Metabolite Usnic Acid against High Fat Diet Induced Atherosclerosis Rat Model
Linna Guo, Xiaojuan Gao
pp. 264–275 · DOI: 10.5530/ijper.20257128 · Published Jan-Mar 2025
Background Cardiovascular diseases and its associated chronic disorders are was and tend to be a global threat for centuries. 80% of cardiovascular diseases were reported in the lower and middle income countries. Chronic…
Article
Natural Product Goniothalamin Induced NADPH-Diaphorase Expression in the Liver: A Possible Role of Nitric Oxide in Hepatoprotection
Hui Man Yap, Abdalaziz Faleh Albalawi, Naif Hussain Alhussain, Abdullah Hamdan Alharbi, Morizeeq Ahamed Ibrahim, Mohamed Ali Seyed
pp. 276–286 · DOI: 10.5530/ijper.20256291 · Published Jan-Mar 2025
Background/Aim Goniothalamin (GTN) has received significant attention for its selective cytotoxicity toward multiple tumor cell lines, without causing any effect on normal cells. Despite a lack of toxicity, the poor pote…
Article
Effect of Evodiamine in the Prevention and Treatment of 5-FU Induced Diarrhea in Swiss Albino Rats: A Preliminary Study
Bianjiang He, Ke Su, Mingming Wei, Guangya Zhou
pp. 287–296 · DOI: 10.5530/ijper.20250135 · Published Jan-Mar 2025
Aim of the Study To assess the antidiarrheal properties of Evodiamine in the prevention and treatment of Chemotherapy-Induced Diarrhea (CID) in experimental rats. Materials and Methods The Swiss albino female rats (8-12 …
Article
Neuroprotective Potential of Marrubium vulgare Linn. Extract against Scopolamine-Induced Alzheimer’s Type Dementia in Mice
Yogesh Verma, Sunishtha Kalra, Himanshu Sachdeva, Praveen Kumar, Govind Singh
pp. 297–307 · DOI: 10.5530/ijper.20255860 · Published Jan-Mar 2025
Background Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment, cognitive decline and behavioural changes. It primarily affects individuals over the age of 65. It poses…
Article
Structural Elucidation of Phytoconstituents (Phenols, Long Chain Fatty Acids, Flavonoid, Terpenoids, Coumarin) Found in Chromolaena odorata through Gas Chromatography: Mass Spectroscopy (GC-MS) Technique
Manjushree Kundalik Pawar, Jayesh Ashok Dwivedi, Udichi Kataria Dwivedi
pp. 308–315 · DOI: 10.5530/ijper.20254846 · Published Jul-Sep 2024
Background Chromolaena odorata (CO) is a well-known ethnopharmacological herb in Ayurveda and exhibits a comprehensive range of therapeutic potential. Objectives The objective of this research was to study the phytochemi…
Article
In vitro Study on the Antioxidant and Anti-Inflammatory Capabilities of Borassus flabellifer Seedcoat
Madhubala Natarajan, Arul Amutha Elizabeth
pp. 316–325 · DOI: 10.5530/ijper.20255122 · Published Oct-Dec 2024
Aims Borassus flabellifer, commonly known as Palmyra palm, Ice apple, Nungu (Tamil) is prevalent in South Asia. This study is focused on determining the anti-oxidant and anti-inflammatory activity of ethanolic extract is…
Article
Blockade of Multiple Pathways of P. falciparum by Quinoxaline from Curry Fish (S. hermanni) Using an in silico Approach
Prawesty Diah Utami, Varidianto Yudo, Retno Budiarti
pp. 326–337 · DOI: 10.5530/ijper.20255346 · Published Jan-Mar 2025
Introduction The escalating mortality and morbidity rates due to malaria present an unsolved global health problem. Previous in vivo research has revealed the antimalarial effect of S. hermanni. However, the mechanism of…
Article
Chemical Profiling and in vitro Evaluation of the Antioxidant, Anti-Inflammatory, and Anti-Bacterial Effects of Algerian Solanum melongena L.
Rabah Kellab, Fouzi Boulkenafet, Serine Amokrane, Zebida Benmakhlouf, Chawki Bensouici, Azeddine Bounamous, Abdelouahab Yahia, Simonetta Lambiase, Fahd Abdo Al-Meklafi, Mohammed Ahmed Wadaan
pp. 338–350 · DOI: 10.5530/ijper.20250132 · Published Jan-Mar 2025
Aim Solanum melongena L., commonly known as eggplant, is a low-calorie vegetable with high nutritional value due to its rich fiber, vitamins, minerals, and bioactive compounds, particularly polyphenols, which provide ant…
Article
The Effect of Pistacia vera L. (Pistachio) Extract on Fatty Acid Biosynthesis and Total Proteins against Carbon Tetrachloride (CCl4)-induced Damage in Saccharomyces cerevisiae
Zehra Gökçe
pp. 351–358 · DOI: 10.5530/ijper.20257396 · Published 2025
Background and Aim: Pistacia vera (PV) is an important species with economic value, rich compound content and high biological activity. Carbon Tetrachloride (CCl4) used in our study is an important reactive toxic compoun…
Article
Conessine Attenuates Diabetic Nephropathy in Rats through Inhibition of Hyperglycemia-Induced Oxidative Stress, Inflammation and Apoptosis
Lin Li, Qian Wang, Yungiang Wang, Chenchen Li, Yan Gao, Li Zhang
pp. 359–369 · DOI: 10.5530/ijper.20250182 · Published Jan-Mar 2025
Background One type of chronic kidney disease is diabetic nephropathy. One of the main causes of end-stage renal disease and chronic kidney disease is diabetic nephropathy. The objective of this study was to assess the e…
Article
Hepatoprotective Properties of Acacia nilotica Bark Extract against H2O2 Induced Oxidative Damage in Normal Liver (LO2) and Cancer (HepG2) Cells
Hong Jian Cai, Qian Yan, Zhongying Du, Yinghui Bi
pp. 370–376 · DOI: 10.5530/ijper.20256767 · Published Jan-Mar 2025
Background Liver cancer's severity has prompted interest in herbal remedies for hepatotoxicity and the disease. Acacia nilotica (Vachellia nilotica), valued for its traditional medicinal properties, particularly in its a…
Article
Evaluation of Hepatoprotective Potential of Bougainvillea spectabilis Extracts against CCl4-Induced Hepatotoxicity
Prabhat Kumar Das, Jai Singh Vaghela
pp. 377–383 · DOI: 10.5530/ijper.20250293 · Published Oct-Dec 2024
Background Injuries and fatalities caused by liver disease are among the highest in the globe. Every year, more than one million people lose their lives due to chronic hepatitis, which affects an estimated 500 million pe…
Article
Use of Liquid Solid Technique for Development and Evaluation Study of Nifedipine Tablets to Enhance Dissolution Characteristics
Amaresh Prusty, Susanta Kumar Panda, Sameer Kumar Prusty
pp. 384–391 · DOI: 10.5530/ijper.20255571 · Published Jan-Mar 2025
Objectives The current research finding suggests dissolution enhancement of nifedipine tablets using Liquid solid technique. Materials and Methods The drug's solubility in various liquid carriers has been examined, out o…
Article
A Study on the Mechanism of Herb-Partitioned Moxibustion at the Navel Based on the Gut-Brain Axis Theory in the Prevention and Treatment of Insomnia via the BDNF/TrkB Pathway
Xiaona Ye, Chao Sun, Qingyin Liu, Yingying Zhao, Xiuqun Lin, Xinglin Zhao, Xingjun Han
pp. 392–399 · DOI: 10.5530/ijper.20251193 · Published 2025
Aim/Background: To examine the impact of navel moxibustion, a form of herb-partitioned moxibustion applied at the belly button, on Brain-Derived Neurotrophic Factor (BDNF), Tyrosine Kinase receptor B (TrkB) and 5-Hydroxy…
Article
Lidocaine Alleviates Myocardial Ischemia-Reperfusion Injury in Rats through JNK Signaling Pathway
Jie Qi, Xiangkong Song, Qingdao Zhang, Qianqian Yang, Qingtan Zhang, Meiling Liu, Yuxia Gao
pp. 400–406 · DOI: 10.5530/ijper.20250322 · Published Jan-Mar 2025
Aim/Background This study aimed to explore the impact of lidocaine on rats subjected to MIR injury and to elucidate the underlying mechanisms involved in this process. The objective was to examine how lidocaine affects t…