Volume 59, Issue 1S

2025 · pp. 1–7 · 40 articles

Volume: 59
Issue: 1S
Published: 2025
Pages: 1–7
Articles: 40
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Original Article Review Article

In this issue

Original Article

Article
Development and Characterization of Atenolol Based Microsponge Gel for Ophthalmic Delivery
Archana Dhyani, Ganesh Kumar
pp. 1–7 · DOI: 10.5530/ijper.20255777 · Published Jan-Mar 2025
Background Ocular drug delivery is hindered by a number of reasons, including nasolacrimal drainage, tear turnover and eye blinking. One of the important factors is rapid removal of drug from the eye. The fast eliminatio…
Article
Review of Existing Antibiotic Stewardship and Impact on Antimicrobial Resistance during COVID-19 in the Health Sector of the Emirate of Abu Dhabi, United Arab Emirates
Kanika Vats, Kuldeep Singh
pp. s46–s51 · DOI: 10.5530/ijper.20255637 · Published Jan-Mar 2025
This study examined the present situation of Antimicrobial Resistance (AMR) and prevailing Antimicrobial Stewardship Programs (ASP), and its impact during COVID-19 globally and specifically in Abu Dhabi, UAE aiming to id…
Article
Hydrotropy as a Tool for Enhancing Mefenamic Acid Solubility: A Comprehensive Study
Pankaj Sharma, Pradhyumn Shivhare, Vinay Jain
pp. s52–s62 · DOI: 10.5530/ijper.20250092 · Published Oct-Dec 2024
Background Nonsteroidal anti-inflammatory drugs, or NSAIDs, including mefenamic acid, are commonly used for the relief of moderate to serious pain. However, their poor water solubility affects their bioavailability and p…
Article
Fabrication and Comparative Assessment of Solid Dispersion and Nanosuspension in Solubility Enhancement of Antihypertensive Drug
Shyam Ghadlinge, Preeti Sable, Swaroop Lahoti, Jaiprakash Sangshetti
pp. s63–s70 · DOI: 10.5530/ijper.20254202 · Published Oct-Dec 2024
Background Azilsartan, a poorly soluble angiotensin receptor blocker belonging to BCS class II, faces challenges related to low solubility and bioavailability. To address these issues, this study compares two formulation…
Article
Hansen Solubility Parameter Approach in the Screening of Lipid Excipients for the Development of Lipid Nano Carriers
Sankaranarayanan Vijayalakshmi, Somaskandan Subramanian, Sellappan Malathi
pp. s71–s80 · DOI: 10.5530/ijper.20254852 · Published Jul-Sep 2024
Background The complex physicochemical properties of the lipids have considerable impact on the solubility and stability of the Lipid Based Nanocarriers (LBN). The major challenge in the successful development of LBN lie…
Article
Formulation and Evaluation of Temperature Sensitive in situ Ocular Gel Drug Delivery System of Acetazolamide for the Treatment of Glaucoma
Bhuvnesh Kumar Singh, Nishi Sharma, Sumit Durgapal, Mahandra Rana, Ashok Kumar Rajpoot, Kajal Gurow, Vaishali
pp. s81–s88 · DOI: 10.5530/ijper.20255365 · Published Jan-Mar 2025
Background Conventional eye formulations are generally flushed away from the lacrimal area due to the rapid elimination of drugs from this region, with only a small amount being absorbed. The short-term precorneal contac…
Article
QbD Based Development, Characterization and Pharmacokinetic Evaluation of Enzalutamide-Loaded Cyclodextrin Nano Sponges for Enhanced Drug Delivery
Ramya Teja Medarametla, Gadela Venkata Radha
pp. s89–s101 · DOI: 10.5530/ijper.20255427 · Published Jan-Mar 2025
Aim/Background The aim of this study was to enhance the bioavailability of Enzalutamide by developing cross-linked cyclodextrin nanosponges loaded with the drug (EZL-CDNS). The objective of the work is to thoroughly inve…
Article
Characterisation and Toxicity Evaluation of Synthesized Phloridzin Chitosan Nanoparticles in in vivo Model
Aiswarya Gangadheran Nambiyar, Brindha Durairaj
pp. s102–s113 · DOI: 10.5530/ijper.20255549 · Published Jan-Mar 2025
Background Phloridzin, a plant compound is of interest in the field of research due to its antioxidant, anti-inflammatory, anticancer and antidiabetic activity. The current study’s objectives were to create, characterize…
Article
Formulation and Evaluation of Acyclovir Loaded Aspasomal Gel for Effective Management of Herpes
Anuya Vimalakar Babar, Kishori Prasanna Sutar, Siddarth Vijay Usulkar
pp. s121–s131 · DOI: 10.5530/ijper.20254263 · Published Jan-Mar 2025
Objectives The aim of the present study is to formulate and evaluate acyclovir loaded aspasomal topical gel by using Aloe vera gel base to enhance skin permeation and reduce the associated oral side effects of acyclovir.…
Article
Bio-Simulation Studies of Valganciclovir Hydrochloride: Molecular Descriptor-Based QSAR Modelling and Swiss ADME Analysis Using in silico Models
Yashavanth Gangadhar, Amal Rasul Al Turaifi, Nimbagal Raghavendra Naveen, Prakash Goudanavar, Santhosh Fattepur, Nagaraja Sreeharsha, Mohammed Monirul Islam, Muhammad Shahzad Chohan
pp. s132–s137 · DOI: 10.5530/ijper.20251137 · Published Jan-Mar 2025
Aim To evaluate the pharmacokinetics and toxicity properties of Valganciclovir Hydrochloride, a potent antiviral agent, using in silico models. Background Valganciclovir Hydrochloride is an FDA-approved antiviral agent a…
Article
Chitosan-Based Linezolid Dry Powder Inhalers: A Novel Approach for Targeted Pulmonary Delivery in Tuberculosis Treatment
Girish Meravanige, Mallamma Thippeswamy, Predeepkumar Narayanappa Shiroorkar, Nimbagal Raghavendra Naveen, Prakash Goudanavar, Nagaraja Sreeharsha
pp. s138–s150 · DOI: 10.5530/ijper.20250001 · Published Jan-Mar 2025
Introduction Tuberculosis (TB) remains one of the leading causes of infectious deaths worldwide, ranking second only to COVID-19. The rise of Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR) TB strains high…
Article
Investigating the Impact of Acute and 28-days Oral Exposure to Decaprenyl phosphoryl-β-D-ribose 2’- epimerase (DprE1) Inhibitors on Vital Organ Function in Swiss Albino Mice
Jineetkumar Gawad, Chandrakant Bonde, Smita Bonde, Mayank Sharma, Dinesh Suthar, Mahesh Palkar, Vishal Beldar, Bharat Dhokchawle, Vaishali Raghuwanshi
pp. s151–s158 · DOI: 10.5530/ijper.20256810 · Published Jan-Mar 2025
Aim/Background Tuberculosis (TB) is a severe airborne infectious disease caused by Mycobacterium tuberculosis, a contagious bacillus and the second leading cause of mortality. A pivotal obstacle in Tuberculosis (TB) ther…
Article
Statistically Optimized Nano Emulsion Enhances Bone Regeneration Efficiency of Ipriflavone in Osteoporosis-Induced Zebrafish Model
Anish John, Sreehari Malangai Subramanyabhat, Masmarika Mohan, Anoop Narayanan Vadakkepushpakath, Gunimala Chakraborty, Manohar Mahadev
pp. s159–s168 · DOI: 10.5530/ijper.20256334 · Published Jan-Mar 2025
Background The objective of this research was to develop a nano emulsion of ipriflavone (IP nano emulsion), a soy isoflavone to enhance its solubility, bioavailability and bone regeneration potential. Materials and Metho…
Article
The Clinical Implications of Thyroid Dysfunction and its Association with Dyslipidemia and the Geographical Effect: A Comparative Study from Different Altitudes in Saudi Arabia
Saif Aboud M Alqahtani
pp. s169–s178 · DOI: 10.5530/ijper.20255187 · Published Jan-Mar 2025
Background Thyroid disorder is one of the most prevalent critical issues for public health in clinical practice. Lipid profiles and cardiovascular attenuation are significantly affected by thyroid dysfunction. Thyroid dy…
Article
Evaluation of Antiparkinsonism Activity of Manilkara zapota (L.) P. Royen Leaf Extract in Haloperidol-Induced Parkinsonism in Swiss Albino Mice
Zeenath Banu, Shaista Samreen, Safura Ayesha Mujeeb
pp. s179–s189 · DOI: 10.5530/ijper.20250031 · Published Jan-Mar 2025
Background Manilkara zapota, a plant with a rich history in traditional medicine, holds potential as a therapeutic agent. However, its neuroprotective properties remain largely unexplored, highlighting the need for furth…
Article
Preclinical Evaluation of Thrombocytopenic Activity of Hydro-Alcoholic Extract of Psidium guajava L. Fruits on Wistar Rats with in silico Modelling on Dengue Virus Protease Inhibitors
Soumik Bhattacharjee, Abhik Si, Amit Kumar Halder, Sumit Nandi
pp. s190–s197 · DOI: 10.5530/ijper.20250199 · Published Jan-Mar 2025
Background The prime objective of the investigation is to measure the capability of expanding the enumeration of platelet in rodent model utilizing hydro-alcoholic extract of Psidium guajava L. fruit in addition with in …
Article
Role of Broccoli Fiber for Amoxicillin Delivery and Gut Biome Survival
Gatla Venkata Amruthavalli, Arumugam Vijayalakshmi
pp. s198–s213 · DOI: 10.5530/ijper.20255476 · Published Jan-Mar 2025
Aim Broccoli fiber has enormous safety net as well as high pre-biotic value. Amoxicillin is although an effective drug against infections is equally harmful to gut microbiota and therefore the above side-effect impedes t…
Article
In vitro Evaluation of Curcumin and Quercetin in Combination on Oxidative Stress
Archita Katrolia, Vedpal, Vikesh Kumar Shukla, Rohit Singh, Sheenu Chandra, Rajeshkumar Raman
pp. s214–s220 · DOI: 10.5530/ijper.20254445 · Published Oct-Dec 2024
Background Flavonoids are the natural product belongs to an important class of plant secondary metabolites. They are polyphenolic compounds and known for decades as a potent natural antioxidant. Curcumin (flavonoid polyp…
Article
Comparative Study of Quercetin Content in Marketed Seeds of Linum usitatissimum L. (Flax), Salvia hispanica L. (Chia), and Helianthus annuus L. (Sunflower) and their Microgreens Using HPTLC from West Bengal
Tushar Adhikari, Priya Bardhan Ray, Prerona Saha
pp. s221–s228 · DOI: 10.5530/ijper.20255309 · Published Jan-Mar 2025
Background Microgreens, the early developmental stage of edible plants, have gained prominence for their dense nutrient composition. Yet the variations in quercetin content among different microgreen species remain insuf…
Article
Ziziphus hamur Engl., a Rare Medicinal Plant Modulates Cytokine and Hematological Levels during Sub-Acute Toxicity Studies in Wistar Rats
Kalandar Ameer, Mohamed Ali, Chala Olana Muleta, Natarajan Yasothkumar, Sankaran Balakrishnan, Kilari Geethanjali, Nouf M. Alyami, Hossam M. Aljawdah, Sulaiman Ali Alharbi, Ravi Kasiappan, Senthilkumar Subramanian
pp. s229–s242 · DOI: 10.5530/ijper.20257420 · Published Jan-Mar 2025
Introduction Ziziphushamur Engl. (Vernacular name: Xamurgob) is a thorny shrub native to Ethiopia, Kenya and Somalia. The plant is extensively used in the traditional system of the Somali region in the treatment of jaund…
Article
Azadirachta indica Fruit Mucilage Aided Mucoadhesive Microspheres of Acyclovir for Drug Entrapment and Mucoadhesive Time Assets with Design-Expert Software
Gorantla Naresh Babu, M Menaka, Hindustan Abdul Ahad
pp. s243–s255 · DOI: 10.5530/ijper.20256428 · Published Jan-Mar 2025
Introduction Mucoadhesive microspheres for drug delivery are retained in the stomach for an extended period for localized drug release and effect. Objectives This research aims to explore the mucoadhesive properties of A…
Article
Identification of Novel Drug Targets and Potential Antibacterial Traditional Chinese Medicine Compounds for Klebsiella pneumoniae through in silico and Antibacterial Activity Evaluation
Yanping Li, Suresh Kumar, Hao Peng, Lihu Zhang
pp. s256–s263 · DOI: 10.5530/ijper.20250167 · Published Jan-Mar 2025
Background Klebsiella pneumoniae is a ubiquitous opportunistic pathogen that poses a significant threat to hospitalized patients by causing a wide range of infections. The alarming increase in clinical resistance to all …
Article
Knowledge, Attitude and Practice (KAP) of the Healthcare Professionals and Community towards Patient Counselling in Tertiary Care Hospital
Dhanraj Patil, Kiran Shelar, Gayatri Korade, Prince Rituraj, Rushika Mhaske, Midhun Mathew Kizhakethil
pp. s264–s273 · DOI: 10.5530/ijper.20254916 · Published 2025
Background: Patient counselling is recognized as an integral component of healthcare services, providing essential guidance to patients. However, it has been observed that in India, practical attendance of designated pat…
Article
Stability Indicating RP-HPLC Method Development and Validation for the Simultaneous Quantification of Remogliflozin Etabonate and Metformin HCl
Patel Vishva Shailesh kumar, Kapupara Pankaj Popatlal
pp. s274–s282 · DOI: 10.5530/ijper.20253781 · Published Jan-Mar 2025
Aim This Study aimed to develop a stable, efficient, and reproducible RP-HPLC method that indicates stability, for the simultaneous determination of Remogliflozin Etabonate and Metformin HCl. Materials and Methods The Se…
Article
RP-HPLC Single Advance Method with Validation Studies for Imipramine Hydrochloride and its Intermediates
Vighnesh Pradeep Nalawade, Faiz Hussain Sayyed, Sonali Ramgopal Mahule, Pandurang Maruti Chavhan, Nitin Rathod
pp. s283–s291 · DOI: 10.5530/ijper.20256210 · Published Jan-Mar 2025
Background A quantifiable method has been developed to determine the key starting material, its intermediates and known impurities in the presence of Imipramine Hydrochloride in the final API of a synthetic laboratory sa…
Article
LC-MS/MS Method for Simultaneous Estimation of Lopinavir and Ritonavir in Bulk and Dosage Form
Paduri Amani, Narender Malothu, Chamakuri Kantlam, Chakravarthi Guntupalli
pp. s292–s299 · DOI: 10.5530/ijper.20256853 · Published Jan-Mar 2025
Aim This study introduces a novel simultaneous analytical quantification of Lopinavir (LPV) and Ritonavir (RTV) in drug products by using LC-MS/MS. Materials and Methods The present study were carried out on Acquity™ LC …
Article
Method Development for the Simultaneous Estimation of Prazosin and Polythiazide by UPLC Using QbD Approach
Pydi Geetha Bhavani, Durairaj Akila Devi
pp. s300–s311 · DOI: 10.5530/ijper.20250020 · Published Jan-Mar 2025
Introduction Prazosin is a quinazoline derivative and a selective antagonist of the α1 adrenergic receptor. The atomic structure is C19H21N5O4 and its molecular weight is 383.41 Prazosin is a helpful medication for manag…
Article
Unlocking Anti-Inflammatory Potential: Virtual Discovery and ADMET Evaluation of Novel Pyrazole-Based COX-II Inhibitors
Vipul M. Patil, Harinath N. More
pp. s312–s322 · DOI: 10.5530/ijper.20256457 · Published Jan-Mar 2025
Background Inflammation, a complex biological process mediated by arachidonic acid metabolites, plays a crucial role in various diseases like arthritis, psoriasis and neurodegenerative disorders. The Cyclooxygenase (COX)…
Article
Synthesis and Evaluation of 2, 5-substituted Pyrazolone for Neuroprotective Potential in SH-SY5Y Human Neuroblastoma Cells
R. Manikandan, K. Devi, D. Rajalingam
pp. s323–s332 · DOI: 10.5530/ijper.20256349 · Published Jan-Mar 2025
Aim To carry out Synthesis and Evaluation of novel 2, 5-substituted Pyrazolonefor Neuroprotective Potential in SH-SY5Y Human Neuroblastoma Cells. Materials and Methods Alzheimer’s Disease (AD) has become a serious public…
Article
Design and Synthesis of N-Phenyl-2-(Phenyl-Amino) Acetamide Derivatives as FVIIA Inhibitors for Effective Anticoagulant Activity
Yasmin Hamid Momin, Shailaja Prakash Desai, Pranali Ananda Chavan
pp. s333–s340 · DOI: 10.5530/ijper.20255768 · Published Jan-Mar 2025
Aim Factor Vila is a glycosylated disulfide-linked heterodimer that belongs to the serine protease family involved in the coagulation process. Inhibition of factor Vila is one of the crucial targets for novel anticoagula…
Article
The Effect of Pharmaceutical Care Practices on Clinical Problem-Solving Decision-Making Competencies and Students’ Preparedness: A Cross Sectional Study
Fatima Ulya Yürük, Güldem Mercanoğlu, Gülrû Yüksel, Zeynep Yeşim Ay, Nazlıcan Uçar, Songül Tezcan
pp. s341–s346 · DOI: 10.5530/ijper.20255958 · Published Jan-Mar 2025
Background As clinical responsibilities continue to grow, it becomes essential for clinical pharmacists to acquire advanced competences, such as patient monitoring, patient-specific drug therapy design and evaluation, an…
Article
A Psychological Exploration Towards Indian Education Fraternity during the COVID-19 Pandemic
Aruna Dhamija, Shilpa Tandon, Sachit Paliwal, Parul Agrawal
pp. s347–s354 · DOI: 10.5530/ijper.20255436 · Published Jan-Mar 2025
Aim/Background The purpose of the current study is to understand the COVID-19 pandemic as the greatest psychological challenge that humankind has ever faced. COVID-19 started in China in December 2019 and has conquered t…
Article
Antimicrobial Utilization in a Rural Children’s Hospital of South India
Mohanraj Rathinavelu, Veeramani Ganesan, Mallela Vijaya Jyothi
pp. s355–s360 · DOI: 10.5530/ijper.20255423 · Published Jan-Mar 2025
Background The “more-is-better” antimicrobial prescribing philosophy besides resistance is a significant contributor to suffering and death in children. Only a few nations have given comprehensive and comparable statisti…
Article
Effect of High Dose Folic Acid Supplementation on the Prevention of Pre-Eclampsia in Pregnancy with Hypertension
Chaoyou Zhou, Qiongshan Li, Yinjian Zhou, Zhuangzhuang Xu, Yan Jin
pp. s361–s366 · DOI: 10.5530/ijper.20255955 · Published Jan-Mar 2025
Background “Pre-eclampsia” is one of the most dangerous pregnancy complications, increasing the risk of both the mother and the baby dying prematurely. Because there have been conflicting findings on whether folic acid c…
Article
Comparative Study of Aqueous and Alcoholic Extracts of Roots of Bauhinia variegata Linn. on Cafeteria Diet Induced Obesity
Aryaa Ankalikar, Agadi Hiremath Viswanthaswamy, Vaishali Undale
pp. s367–s374 · DOI: 10.5530/ijper.20254509 · Published Jan-Mar 2025
Background Obesity is typically characterized by excess deposition of adipose tissue. Along with dietary management, increase in physical activity, lifestyle modification, surgical intervention, drug treatment is also av…
Article
Synthesis, Molecular Docking Study and Antimicrobial Evaluation of Some 1,2,4-Triazole Compounds
Munther Abduljaleel Muhammad-Ali, Ekhlas Qanber Jasim, Abeer Issa Mohammed
pp. s375–s389 · DOI: 10.5530/ijper.20255394 · Published 2025
Aim: The objective of this study is synthesis of 1,2,4-triazole derivatives, evaluation there in vitro antimicrobial activity and showing the molecular docking. Materials and Methods: Two series of 5-alkylthio-3-aryl-4-p…
Article
Use of Antidiabetic Drugs and Glycemic Control with Life Style Management in Type II DM-A Cross-Sectional Study General Practice in Odisha
Prabhudatta Mohapatra, Durga Madhab Kar, Karmajeet Rath, Abhisek Pal
pp. s390–s396 · DOI: 10.5530/ijper.20255065 · Published Apr-Jun 2025
Aim/Background Our objective is to describe the patterns of prescribing drug combinations and lifestyle modification in which therapy focuses on SGLT2 and DPP4 inhibitors and dose variation according to the blood glucose…

Review Article

Review
Biomarkers Unveiling Neurodegeneration: Keys to Progression and Therapeutic Insights
Joy Das, Utpal Bhui, Shreya Chowdhary, Subhajit Sarkar, Indra Kumar Ghoshal, Soumyadip Nayak, Rahul Bishayee, Navneet Khurana, Bimlesh Kumar, Neha Sharma
pp. s1–s15 · DOI: 10.5530/ijper.20250179 · Published Jan-Mar 2025
Neurodegenerative diseases constitute a pressing global health challenge, characterized by the gradual loss of neuronal function and structure, leading to cognitive impairment and motor deficits. Biomarkers play a crucia…
Review
Bio-Conjugated Metallic Complexes in Drug Design
Dilend Patle, Narendra Pratap Singh Sengar
pp. s16–s24 · DOI: 10.5530/ijper.20255296 · Published Jan-Mar 2025
Background This comprehensive review highlights the importance of bio-conjugated metallic complexes in drug design, particularly in the field of metallo-pharmaceutical science. The review emphasizes the need for biologic…
Review
Insight into the Synthesis Approaches of Oxadiazole and its Derivatives, Focuses on their Pharmacological Activities
Sadhana Sharma, Chandana Majee, Rupa Mazumder, Avijit Mazumder, Pankaj Kumar Taygi, Sachin Kumar Singh
pp. a25–a45 · DOI: 10.5530/ijper.20250270 · Published Oct-Dec 2024
Oxadiazoles and their derivatives represent a significant class of organic compounds, wielding profound implications in both the realms of medicinal science and heterocyclic rings housing oxygen and nitrogen atoms, has g…