Volume 59, Issue 2S

2025 · pp. s443–s453 · 33 articles

Volume: 59
Issue: 2S
Published: 2025
Pages: s443–s453
Articles: 33
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
Casting a Spotlight on Factorial Design: Exploring the Power of DoE for Experiment Screening and Optimization: A Mini Review
Prathap Madeswara Guptha, Vijayaraj Surendran, Raghavendra Kumar Gunda
pp. s399–s409 · DOI: 10.5530/ijper.20256017 · Published Apr-Jun 2025
Design of Experiments (DOE) is a powerful and systematic approach used in various fields to efficiently plan, execute and analyze experiments. This review provides a comprehensive overview of the application of DOE in th…

Original Article

Article
A Qualitative Study on Lecture Capturing System in Pharmacy Education-Learners’ Perspective
Saranraj Loganathan, Rajkumaran Soundarraj, Vishwalingam Murugan Sujetha
pp. s410–s413 · DOI: 10.5530/ijper.20250352 · Published Apr-Jun 2025
Background: The Lecture Capturing System method was implemented in Pharmacy education for a better understanding of the specific content and provides flexibility to review. This study observed pharmacy learners’ perspect…
Article
Formulation and Evaluation of Simvastatin Loaded Nanostructured Lipid Carrier for Topical Drug Delivery
Madhuri Desai, Shalaka Dhanna, Sujata Jadhav, Akshada Koparde, Akansha Dashwanat, Rutuja Gharal
pp. s414–s425 · DOI: 10.5530/ijper.20250097 · Published Apr-Jun 2025
Introduction: Simvastatin, a BCS II drug, has poor water solubility and low bioavailability. Nanostructured Lipid Carriers (NLCs) can enhance its bioavailability. This study investigates the potential of NLCs to improve …
Article
Optimized Vildagliptin Microsphere Formulation and in vitro Characterization Using 23 Factorial Design Analysis
Sundaramoorthi Revathi, Pavadai Anitha, Sathappan Jenifer, Sivakumar Senthil Rajan
pp. s426–s435 · DOI: 10.5530/ijper.20250227 · Published Apr-Jun 2025
Background: Vildagliptin is a dipeptidyl peptidase-4 inhibitor employed for the intervention of non-insulin-dependent diabetes mellitus which has a short half-life. The intention of this work is to devise and qualify vil…
Article
Bilosome Nanocarriers for Enhanced Oral Bioavailability and Cardiovascular Activity of Milrinone
Kiruthika Santhinathan, Susmitha Durai, Rijivana Sirajudeen, Gopinath Govindhraji, Saravanan Gopal, Gayathri Kumararaja
pp. s436–s442 · DOI: 10.5530/ijper.20250292 · Published Apr-Jun 2025
Background: Cardiovascular Diseases (CVDs) are the main causes of death in both industrialized and developing nations, which are mostly brought on by poor lifestyles and insufficient physical activity. Recent years many …
Article
Optimizing Loratadine Delivery: Development of Niosomal Transdermal Patches
Charan Sailaja, Pradeep Kumar Bhupalam
pp. s443–s453 · DOI: 10.5530/ijper.20250564 · Published 2025
Objectives: To improve and optimize loratadine-loaded niosomal transdermal patches with a Box-Behnken Design to enhance drug delivery and evaluate their potential as an effective alternative to oral administration for al…
Article
Formulation and Characterization of Chitosan Based Oral Nanoparticles of Poorly Water-Soluble Drug Lurasidone Hydrochloride
Purushottam Gangane, Pallavi Ingle, Vijaya Rabade, Harigopal Sawarkar
pp. s454–s463 · DOI: 10.5530/ijper.20253872 · Published Apr-Jun 2025
Aim: The purpose of research was to refine the solubility and dissolution assessment of lurasidone hydrochloride, a poorly water-soluble drug with a pH dependent solubility, by preparing chitosan-based nanoparticles usin…
Article
Efficient Fabrication and Assessment of Telmisartan Fast-Dissolving Films Using Solvent Casting Approach
Ashish Sriram Mishra, Gouranga Dutta, Abimanyu Sugumaran
pp. s464–s472 · DOI: 10.5530/ijper.20254097 · Published Apr-Jun 2025
Introduction: Telmisartan (TLM) is a common angiotensin II receptor antagonist used to treat hypertension. However, the drug's limited bioavailability and delayed onset duration diminish its efficacy. To address these co…
Article
Formulation and Evaluation of Chronotherapeutic Delivery of Sacubitril Valsartan for Management of Hypertension
Rajeswari Aleti, Monika Nijhawan, Gunnam Sailaja
pp. s473–s481 · DOI: 10.5530/ijper.20254583 · Published Apr-Jun 2025
Introduction: Early morning surge in blood pressure is a major cause of sudden cardiac arrest. Objectives: Development and evaluation of chronomodulated Compression Coated Tablets (CCT) for bedtime dosing of sacubitril-v…
Article
A DoE Study for Optimization of Control Quality Attributes and Critical Material Attributes in Development of Almotriptan Fast Dissolving Tablet for the Enhancement of Effective Surface Area
Prathap Madeswara Guptha, Raghavendra Kumar Gunda, Murugesan Vanangamudi, Elphine Prabahar A
pp. s482–s493 · DOI: 10.5530/ijper.20255422 · Published Apr-Jun 2025
Background: The primary goal of this study is to increase the effective surface area of Almotriptan and improve disintegration time and diffusion time of the tablet by using a direct compression technique for producing F…
Article
Box Behnken Design: Unleashing the Potential of Desirability Function for Enhanced Permeability of Antidiabetic Nanoparticles
Akanksha Dwivedi, Rajesh Sharma
pp. s494–s507 · DOI: 10.5530/ijper.20255506 · Published Apr-Jun 2025
Aim: The present study is focused to develop and optimize nanoparticulate delivery system for two antidiabetic drugs; Sitagliptin Phosphate (SP) and Empagliflozin (EMP) of BCS class III drugs as a single dosage form usin…
Article
Nanostructured Lipid Carriers Based Gel of Methotrexate for Rheumatoid Arthritis: Development, Characterization and Optimization through Taguchi Design
Malti Arya, Amit Porwal, Koshy Mamman Kymonil
pp. s508–s522 · DOI: 10.5530/ijper.20255540 · Published Apr-Jun 2025
Background: The goal of this work was to develop, optimise and characterise nanostructured lipid carriers containing methotrexate for the treatment of Rheumatoid Arthritis (RA). As materials and process parameters, solid…
Article
Design, Development and Characterization of Losartan Pharmacosomes Encapsulated in Capsule Formulation
Kumararaja Gayathri, Praveena Gandhi, S. Kiruthika
pp. s523–s530 · DOI: 10.5530/ijper.20255974 · Published Apr-Jun 2025
Background: In comparison to conventional vesicular drug delivery techniques, Pharmacosomes are a potential method for vesicular drug delivery that offers a number of advantages. Pharmacosomes are phosphilipid complexes …
Article
Execution of Quality by Design Approach in the Formulation of Fluconazole Inclusion Complex Based Suppository for Vaginal Candidiasis
Pranita Sunil Kanojiya, Rita Naresh Wadetwar, Amita Prasanna Godbole
pp. s531–s551 · DOI: 10.5530/ijper.20256191 · Published Apr-Jun 2025
Aim: The present work was carried out to improve the aqueous solubility of Fluconazole by formulation of inclusion complex using β-cyclodextrin and then loaded into the suppository for the treatment of vaginal candidiasi…
Article
Exploration of Smart Utilization of Biodegradable Nanobubbles in Intensifying the Capsaicin Bioavailability
Hema Kumar A V, Chamakuri Kantlam
pp. s560–s571 · DOI: 10.5530/ijper.20257237 · Published Apr-Jun 2025
Background: Capsaicin (CAP), a naturally occurring alkaloid, shows many promising benefits but is unexplored due to its hydrophobic nature and limited bioavailability. Objectives: To address these limitations, the presen…
Article
Preparation and Evaluation of Exosomes Loaded with Combined Drugs against Colon Cancer
Anita Raj Panigrahi, Shib Swaroop Samal, Srinivas Lankalapalli
pp. s572–s584 · DOI: 10.5530/ijper.20250014 · Published Apr-Jun 2025
Background: Nanoscale delivery systems such as milk exosomes, promising carriers for drug delivery, are used to deliver therapeutic drug molecules to the targeted organs. They possess characteristics that include low imm…
Article
Amelioration of Diabetic Nephropathy in Streptozotocin-induced Diabetic Rats by Jasminum auriculatum vahl Leaves Extract
Manish Kushwah, Avijit Mazumder, Richa Shakya, Pankaj Tyagi, Motamarri Venkata Naga Lalitha Chaitanya
pp. s585–s593 · DOI: 10.5530/ijper.20254714 · Published Apr-Jun 2025
Background: Considering the growing preference for herbal medications over their synthetic counterparts it is the need to combat the global end stage renal disease in Diabetic Nephropathy problem. In AYUSH medicine, the …
Article
Antidepressant-Like Effect of Ethanolic Leaves Extract of Anthocephalus cadamba in CUMS Model of Depression in Swiss Albino Mice
Om Prakash Dhangar, Talever Singh, Himansu Chopra, Ram Babu Tripathi, Shivendra Kumar, Akash Garg, Kuldeep Singh, Devender Pathak
pp. s594–s601 · DOI: 10.5530/ijper.20255377 · Published Apr-Jun 2025
Background: Anthocephalus cadamba owe their family name to ‘runiaceae’. The plant's primary constituents include triterpenes, glycosides, saponins, flavonoids and indole alkaloids, including isocadambine, cadambine and i…
Article
Comparative Optimization of α-Amylase Production in Bacillus velezensis sp. Using Response Surface Methodology and Artificial Neural Networks
Bhimana Sasidhar, Ravindran Saravanan
pp. s602–s625 · DOI: 10.5530/ijper.20254639 · Published Apr-Jun 2025
Background: This study aims to optimize the production of α-amylase from Bacillus velezensis sp. through a comparative analysis of advanced experimental methodologies, specifically Definitive Screening Design-Response Su…
Article
Therapeutic Evaluation of Camel Milk-Derived Lactoferrin for in vivo Anti-Arthritic Efficacy
Anchit Dogra, Avijit Mazumder, Saumya Das, Pratibha Pandey, Motamarri Venkata Naga Lalitha Chaitanya
pp. s626–s632 · DOI: 10.5530/ijper.20254695 · Published Apr-Jun 2025
Background: Arthritis is a prevalent chronic inflammatory condition that significantly impacts individual’s quality of life. Lactoferrin (Lf), a multifunctional glycoprotein found in CM, has shown promising anti-inflamma…
Article
Role of Brain Ang (1-7) With Combination Therapy of Aliskerin in Control of Diabetic Nephropathy
Richa Shakya, Jeetendra Kumar Gupta, Avijit Mazumder
pp. s633–s640 · DOI: 10.5530/ijper.20255883 · Published Apr-Jun 2025
Objectives: Angiotensin (1-7) system has been recognizing as physiologically major content of the renin-angiotensin system. It exhibited that Diabetic Nephropathy (DN), which is prevalent causes of end-stage renal diseas…
Article
Optimizing 3D Structural Predictions of Murine β2-Adrenergic Receptor: Swiss-Model Outperforms AlphaFolds
Vijayalakshmi Gangadhara, Asha Abraham
pp. s641–s655 · DOI: 10.5530/ijper.20256524 · Published Apr-Jun 2025
Background and Aim: The β2 adrenergic receptor is vital in physiological processes and a key target for metabolic syndrome. Understanding the structural attributes of the murine β2-AR is crucial for comprehending metabol…
Article
Microwave-Assisted Synthesis and Characterization of N-Vinyl-2-Pyrrolidone Grafted Almond Gum: A Natural Dietary Polysaccharide for Controlled Release of Diclofenac Sodium
Snehal Pawar, Sopan Nangare, Premkumar Baviskar, Laxmikant Zawar
pp. s656–s669 · DOI: 10.5530/ijper.20256712 · Published Apr-Jun 2025
Background: Gums occurring in nature are widely used in pharmaceuticals for their unique properties and diversified applications. The natural gums are almost safely consumed as food additives as well as drug carriers, al…
Article
Bioanalysis and Validation of Fesoterodine, an Antimuscarinic Agent and its Active Metabolite Using Liquid Chromatography with Tandem Mass Spectrometry
Vijaya Lakshmi Marella, Suneetha Achanti, Kanaka Durga Devi Nelluri, Himaja Nara, Anusha Thondepu, Ramatilaka Unnam, Chetan Mokkapati, Penta Dolly Chaitanya Sudha
pp. s670–s679 · DOI: 10.5530/ijper.20250467 · Published Apr-Jun 2025
Aim: To establish a bioanalytical method with rapid, specific and sensitiveness with tandem mass spectrometric with liquid chromatography for an antimuscuranic agent, fesoterodine and its metabolite, 5-hydroxy methyl tol…
Article
Method Development for Estimation of Azelnidipine and S (-) Metoprolol Succinate in Tablets by UV Spectrophotometry and HPLC Using Student’s T-Test
Saylee Ganorkar, Aditya Bhavsar, Rahul Khiste
pp. s680–s688 · DOI: 10.5530/ijper.20253109 · Published Apr-Jun 2025
Introduction: Azelnidipine a calcium channel blocker belongs to BCS class II and S (-) Metoprolol Succinate belongs to BCS class I. Rationale: Calcium is responsible for inducing smooth muscle contraction. Inhibiting cal…
Article
Quality by Design (QbD) Based Development and Validation of RP-HPLC Method for Simultaneous Estimation of Metformin and Teneligliptin in Bulk and their Pharmaceutical Formulation
Jagatkumar Upadhyay, Shantilal Padhiyar, Kamlesh Jivani, Tejas Patel, Vashisth Bhavsar, Vipul Prajapati
pp. s689–s704 · DOI: 10.5530/ijper.20253717 · Published Apr-Jun 2025
Aim: To develop and validate simple, accurate, precise, sensitive and robust Reversed Phase High Performance Liquid Chromatographic (RP-HPLC) method for simultaneous estimation of metformin and teneligliptin in bulk and …
Article
Response Surface Methodology as a Tool for Stability-Indicating Method Development and Validation for the Determination of Selective EZH2 Inhibitor
Srujani Chimpiri, Deva Rani, Mastanamma Shaik, Madhuri Desavathu, Ankit Gupta
pp. s705–s715 · DOI: 10.5530/ijper.20254323 · Published Apr-Jun 2025
Background: Tazemetostat (TZST) is an efficient first-in-class, selective, EZH2 oral inhibitor which had demonstrated tumor regression and favourable safety in patients with Epithelioid Sarcoma. Methods developed using A…
Article
Spectrophotometric Simultaneous Equation and Area under the Curve Methods for Estimation of Metoprolol Succinate and Telmisartan in Pure Drugs and its Combined Marketed Formulation
Vivek Sharma, Rina Das, Dinesh Kumar Mehta, Anu Chaudhary, Samir Patel, Archita Jayendrakumar Patel
pp. s716–s723 · DOI: 10.5530/ijper.20255416 · Published Apr-Jun 2025
Background: Telmisartan-metoprolol succinate formulations treat hypertension. The primary goal was to develop and evaluate a UV-spectrophotometric method for estimating telmisartan and metoprolol succinate in a combinati…
Article
QbD-Enhanced HPLC Method Development for Vildagliptin and Metformin HCl Formulations
Pankaj Sopan Hasabe, Kishor Vinayak Gaikwad, Venketa Satyanarayana Nandmuri, Akanksha Govind Kolekar, Kalyanraman Lakshmi Narayanan, Samadhan Prakash Pawar
pp. s724–s732 · DOI: 10.5530/ijper.20256263 · Published Apr-Jun 2025
Objectives: This research employs the Quality by Design strategy to design an optimized High-Performance Liquid Chromatography method aimed at analyzing vildagliptin and metformin hydrochloride in pharmaceutical dosage f…
Article
Development and Validation of UV/visible Spectrophotometric Method for Estimation of Piroxicam from Bulk and Formulation
Sandip Mohan Honmane, Kunal Rajaram Yadav, Yuvraj Dilip Dange, Suraj Nijamso Pattekari, Shradha Shivdayal Tiwari, Mahesh Govind Saralaya
pp. s733–s739 · DOI: 10.5530/ijper.20256898 · Published Apr-Jun 2025
Background: Piroxicam (PRX) is a potent anti-inflammatory medicine used both orally and topically to treat arthritis, gout, and other inflammatory disorders. Developing and testing an effective analytical technique is cr…
Article
Development and Validation of a HPLC-PDA Method to Quantification of Ketobemidone in Rat Plasma and its’ Application in Pharmacokinetic Study
Shashipal Aitha, Subramani Devaraju, Jayanti Naga Sri Rama Chandra Murthy, Kiran Kumar Tatapudi, Leela Prasad Geddada, Tiruveedhula Somasekhar, Hemambika Sadasivuni, Muralidharan Kaliyaperumal
pp. s740–s747 · DOI: 10.5530/ijper.20256924 · Published Apr-Jun 2025
Aim: Ketobemidone is an opioid drug that have been using against pain in various circumstances. The current research was aimed to develop and validate a HPLC-PDA method to estimate the ketobemidone in rat plasma. Materia…
Article
Spiked Human Plasma Samples: Stability Indicating Method Development and Validation of Pexidartinib by LCMS
Velagapudi Naga Venkata Kishore, Giri Prasad Gorumutchu, Khandapu Bala Murali Krishna
pp. s748–s757 · DOI: 10.5530/ijper.20256947 · Published Apr-Jun 2025
Aim: Pexidartinib (PDTB) was utilized in the development of a novel bioanalytical LCMS method in human plasma, with Talazoparib (TZPB) serving as the IS (Internal standard). Materials and Methods: The chromatographic sep…
Article
Advanced Solid Phase Extraction Tools for Measuring Bempedoic Acid and its Active Metabolite in Human Plasma by Using LC-MS/MS
Mahesh Meghavath, Nayakanti Devanna
pp. s758–s768 · DOI: 10.5530/ijper.20257284 · Published Apr-Jun 2025
Aim/Background: To simultaneously measure bempedoic acid and its primary metabolite, bempedoic acid metabolite-ESP15228, in human plasma via UPLC-MS/MS, the QuEChERS extraction tactic is not suitable. Instead, employ a t…