Volume 59, Issue 4

Original Article(continued)

1. Article

   Harnessing Saussurea lappa for Anti-leishmanial, Anti-toxoplasmic, and Anti-bacterial Activity: Molecular and Computational Insights

   Manal Mohamed Elhassan Taha, Siddig Ibrahim Abdelwahab, Muruganantham Bharathi, Waleed S. Koko, Ibrahim S. Al Nasr, Tariq A. Khan, Mohamed Eltaib Elmobark, Zia ur Rehman, Sivakumar S. Moni, Syam Mohan, Bassem Oraibi, Hassan Ahmad Alfaifi, Dina Abdulrahman Ismail Albadawi, Ahmed Ali Jerah, Yasir Babiker, Saleh M Abdullah, Ibrahim Abdel Aziz Ibrahim, Abdullah Farasani

   pp. 1429–1443 · DOI: 10.5530/ijper.20251782 · 2025

   Objectives: Saussurea lappa Clark has shown preliminary promise in various biological contexts. This study investigates the antileishmanial, antitoxoplasmic, and antibacterial activities of methanolic extracts from S. la…

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2. Article

   Pharmacological Evaluation of Buchanania lanzan Bark Against Alcohol Induced Liver Cirrhosis in Rats

   Namrata Soundatte, Namit Kudatarkar, Rajashekar Chavan

   pp. 1444–1455 · DOI: 10.5530/ijper.20256322 · 2025

   Aim: The study aimed to assess the potential of Buchanania lanzan bark extract in mitigating alcohol-induced liver cirrhosis effects. Objectives: Included evaluating antioxidant and anti-inflammatory properties, explorin…

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3. Article

   Liquiritin Ameliorates Streptozotocin-Induced Gestational Diabetes in Pregnant Rat Model by Inhibiting Inflammation and Oxidative Stress Responses

   Jiejie Xing, Fang Wang, Junxiu Wei, Chenyuan Cao

   pp. 1456–1465 · DOI: 10.5530/ijper.20251618 · 2025

   Aim/Background: Gestational diabetes is a significant medical complication that can develop during pregnancy, characterized by impaired glucose tolerance. This condition poses risks to both the mother and the developing …

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4. Article

   Wogonoside Mitigates Inflammation and Cell Proliferation via Modulation of NF-κB Signalling Pathway in DMBA-Induced Mammary-Preclinical Model

   Chenyang He, Yu Zhang, Yan Diao, Xingcong Ma, Guochao Mao, Xinyu Wei, Yang Zhao

   pp. 1466–1473 · DOI: 10.5530/ijper.20256082 · 2025

   Objectives: To hypothesis the effect of wogonoside against DMBA-induced Breast Cancer (BC) via TNF-α induced NF-κB signaling pathway a molecular appraoch. Materials and Methods: A 25 mg/kg Body Weight (BW), DMBA mixed do…

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5. Article

   Neutralizing Effects of Mimosa pigra Stem-Bark against Selected Snake Venom from Malaysian Habitat

   Nor Safwan Nor Afendi, Noor Syahila Ahamad Saferi, Vishal Bhagwan Badgujar, Nur Fatin Afiqah Mohd Fazil, Farheen Sami, Sangita Badgujar, Hameeth Shah, Arun Kumar, Shahnaz Majeed, Mohammed Tahir Ansari

   pp. 1474–1482 · DOI: 10.5530/ijper.20257015 · 2025

   Introduction: Mimosa pigra L. (M. pigra) regarded as significant undesirable weed in India, Africa, Australia, South-East Asia and some Pacific islands. Preliminary evidence of the use of the plants by rural community fo…

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6. Article

   In vitro and in silico Analysis Protosappanin B Exerts Anti-Tumor Activity on Breast Cancer Cells via Activating Pro-Apoptotic Caspase Enzymes

   Xia Zhang, Shuangnian Deng

   pp. 1483–1492 · DOI: 10.5530/ijper.20251723 · 2025

   Background: Breast cancer is the most common cancer and the second leading cause of cancer-associated mortality in women globally. Breast cancer can metastasize or recur because of drug resistance and toxicity. Objective…

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7. Article

   Exploring Factors Affecting the Quantitative Analysis of Vitexin, Imperatorin and Gallic Acid in Tri-Kaysornmas Formulation

   Suphatson Limsakul, Wissuta Roopngam, Yanisa Voeisarn, Thanaporn Pongmanachai, Yutthana Chotritthirong, Orawan Monthakantirat, Charinya Khamphukdee, Yaowared Chulikhit, Supawadee Daodee

   pp. 1493–1500 · DOI: 10.5530/ijper.20250137 · 2025

   Background: The Tri-kaysornmas formula is one of the Thai traditional formulas in Thailand. Many phytochemical active compounds are found in this formula such as vitexin, imperatorin and gallic acid. Objectives: The curr…

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8. Article

   Atorvastatin Ameliorates Neuroinflammatory Response in Experimental Intracerebral Hemorrhage Rats through the GSK-3β/β-Catenin Pathway

   Jing Zhao, Mei Li, Lingling Zhang, Qi Zhang

   pp. 1501–1510 · DOI: 10.5530/ijper.20250529 · 2025

   Objectives: This study aimed to elucidate influence of Atorvastatin (ATV) on the neuroinflammatory response in experimental Intracerebral Hemorrhage (ICH) through the GSK-3β/β-catenin Signaling Pathway (SPW). Materials a…

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9. Article

   Modulatory Effects of Dietary Saturated Versus Omega-3 Fatty Acids on Cognitive Impairment, Depressive-Like Behavior, HPA Axis Dysregulation and Systemic Inflammation in Monosodium Glutamate-Treated Young Male Rats

   Hebatallah Husseini Atteia, Amal F. Gharib, Mervat El-Sayed Askar, Manar Hamed Arafa, Gehan A. Ahmed, Amr Tawfik Sakr

   pp. 1511–1521 · DOI: 10.5530/ijper.20251190 · 2025

   Background and Objectives: Children consume fast food rich in saturated fats and flavor enhancers like Monosodium Glutamate (MSG). These agents might alter Hypothalamic-Pituitary- Adrenal (HPA) axis activity, inducing be…

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10. Article

    In silico and in vivo Evaluation of Antitumor Drugs against P. falciparum 3D7 Inhibit the Parasite Growth

    Mohammad Aatif, Mohd Farhan, Ghazala Muteeb

    pp. 1522–1533 · DOI: 10.5530/ijper.20251797 · 2025

    Background: Plasmodium falciparum (P. falciparum) is the most lethal parasite that affectsmalaria in humans. The drugs such as Etoposide, Novobiocin, Netropsin, Nogalamycin and Daunorubicin may be useful in treating such…

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11. Article

    Silencing of S100A16 in Cervical Cancer Cells Inhibits Cancer Cell Growth by Inducing Autophagy via PI3K/AKT/ mTOR Signaling Pathway

    Haibin Zhang, Wenhu Xing, Yufeng Li, Xianyun Xu

    pp. 1534–1545 · DOI: 10.5530/ijper.20251170 · 2025

    Objectives: Cervical Cancer (CC) ranks among the top 3 leading malignancies that affect the female reproductive system. This research focused on examining the impact of S100A16 silencing in HeLa and CaSki cells, alongsid…

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12. Article

    Afzelin Prevents against Lipopolysaccharide-Induced Acute Lung Injury and Sepsis via Inhibiting the Inflammatory Mediators

    Honghui Zhao

    pp. 1546–1552 · DOI: 10.5530/ijper.20251529 · 2025

    Background: One of the main causes of death in critical care units and a serious consequence of sepsis is Acute Lung Injury (ALI). Studies have shown that afzelin reduces inflammation and oxidative damage. However, the p…

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13. Article

    Herniarin Mitigates High-Fat Diet-Induced Atherosclerosis in Rats via Regulation of Hyperlipidemia, Endothelial Dysfunction, Inflammation and Oxidative Stress

    Jingyue Lai, Zongyu Li, Ying Zhang, Hao Guan, Jiancang Ma

    pp. 1553–1564 · DOI: 10.5530/ijper.20251165 · 2025

    Background: Atherosclerosis is a complex and multifactorial disease characterized by the buildup of plaque within the blood vessels, which can result in severe cardiovascular problems. Objectives: The present study attem…

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14. Article

    Therapeutic Potential of Lacidipine against 3- Nitropropionic Acid Induced Huntington's Disease: Based on Molecular Docking, Anti-Inflammatory and Neuroprotective Effects

    Samiyah Alshehri, Muhammad Afzal, Sana Saeed Alqarni, Sattam Khulaif Alenezi, Khalid Saad Alharbi, Mohammad Jaffar Sadiq Mantargi, Imran Kazmi, Nadeem Sayyed, Faisal Imam

    pp. 1565–1581 · DOI: 10.5530/ijper.20250579 · 2025

    Background: Huntington's Disease (HD), a neurological ailment that leads to motor impairment, cognitive decline and psychiatric disorders, has limited treatment options. Hence, there is a pressing demand for new therapeu…

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15. Article

    In silico and In vitro Characterization of Potent CDK2 Inhibitors as Probable Cancer Therapeutics

    Akram Ahmed Aloqbi

    pp. 1582–1602 · DOI: 10.5530/ijper.20251532 · 2025

    Background: Cyclin-Dependent Kinases (CDKs) are a family of serine/threonine protein kinases that play pivotal roles in the regulation of the cell cycle and various cellular processes. Among them, CDK2 is a crucial regul…

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16. Article

    Strengthening Finerenone Assessment: A Central Composite Design Viewpoint for Liquid Chromatographic Method Development

    Paul Richard, Sarath Vothani, Srikrishna Theerthala, Kishore Boddu, Vasanth PM

    pp. 1603–1612 · DOI: 10.5530/ijper.20251429 · 2025

    Background: A RP-HPLC technique was created and proven for the measurement of Finerenone, a new medication currently being studied. The approach was improved to achieve excellent precision, accuracy, and sensitivity for …

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17. Article

    Analytical Method Development and Validation by RP-HPLC and UV Spectrophotometric for Estimation of Daprodustat in Bulk and Pharmaceutical Dosage Form

    Pranita Prabhakar Patil, Sunita Sunil Gagare, Ashish Suresh Jain

    pp. 1613–1622 · DOI: 10.5530/ijper.20250016 · 2025

    Objectives: This research aimed to systematically boost the development and validation of newly devised, precise, reproducible and accurate UV and Reverse Phase High Performance Liquid Chromatography (RP-HPLC) methods fo…

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18. Article

    Identification and Comparison of Phytoconstituents of Essential Oil and Methanolic Extracts of Leaves and Rhizomes of Elettariopsis curtisii Grown in Malaysia via GCMS Analysis

    Engku Nurul Najlaa, Sadia Sultan, Kamran Ashraf

    pp. 1623–1632 · DOI: 10.5530/ijper.20251594 · 2025

    Introduction: Elettariopsis curtisii (Zingiberaceae) is a high-value medicinal plant that has been used by the locals in Southeast Asia mainly to treat bloating and for postnatal care purposes. It contains many valuable …

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19. Article

    Impact of Pharmacist-Led Training on Breast Cancer Awareness and Knowledge: A Quasi-Experimental Pre-Post Study

    Zekiye Yılmaz, Ceren Eliçetin

    pp. 1633–1644 · DOI: 10.5530/ijper.20251409 · 2025

    Background: Breast Cancer (BC) constitutes the primary cause of cancer-related mortality in females and BC burden is projected to rise to 3.19 million cases and 1.04 million deaths by 2040. Given the increasing prevalenc…

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