Volume 60, Issue 1

Original Article(continued)

1. Article

   PLGA Nanoparticle-Embedded Oral Films for Sustained Eletriptan Delivery

   Anju Bala, Inderjeet Verma, Chander Parkash, Km Saiphali, Kapil Kumar, Tarun Kapoor

   pp. 110–126 · DOI: 10.5530/ijper.20274390 · 2027

   Objectives: The study aimed to fabricate and characterize Oral Dispersible Film (ODF) containing PLGA polymeric nanoparticles of Eletriptan Hydrobromide (EH). The ODF system is designed to circumvent pre-systemic metabol…

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2. Article

   Formulation Development and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Azelnidipine for Hypertension

   Rutik Jukti, Abhishek Kanugo

   pp. 114–123 · DOI: 10.5530/ijper.20266497 · 2026

   Introduction/Objectives: Azelnidipine is a novel calcium channel blocker usually recommended for the management of an upsurge in blood pressure. The beneficial activity is circumvented because of extreme lipophilicity (L…

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3. Article

   Optimization of Pitavastatin Calcium and Micronized Fenofibrate Bi-layer Tablets Using Quality by Design

   Jun Woo Park, Il Dae Song, Jae Seon Kang, Kang Min Kim

   pp. 124–131 · DOI: 10.5530/ijper.20260939 · 2026

   Background and Purpose: This study aimed to develop bilayer tablets containing pitavastatin calcium and micronized fenofibrate. Materials and Methods: For optimization of manufacturing based on preliminary formulation re…

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4. Article

   Anticancer Potential of Ligustilide Derived from Extract of Angelica sinensis against Colon Cancer: In vitro and Computer Molecular Docking Studies

   Heng Li

   pp. 127–136 · DOI: 10.5530/ijper.20274023 · 2027

   Background: Colorectal cancer is a substantial global health issue, requiring the advancement of innovative therapeutic strategies beyond traditional methods. Despite progress in treatment options, colorectal cancer cont…

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5. Article

   Formulation, Optimization and in vitro Evaluation of Ibuprofen-Loaded Cubosomal Nano-Formulation for Effective Topical Delivery

   Sujay Hulyalkar, Rachana Pockle, Siddarth Usulkar, Panchaxari Dandagi

   pp. 132–139 · DOI: 10.5530/ijper.20264232 · 2026

   Objectives: This research aims to formulate and assess an Ibuprofen-loaded cubosomal gel that would improve the drug's skin absorption and minimize its oral adverse effects. Hence, clinically relevant drug concentration …

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6. Article

   Thymoquinone Ameliorates Oxidative Stress and Inflammatory Responses and Protects against Monosodium Iodoacetate-Induced Osteoarthritis in Rats

   Wenfeng Shi, Yugang Li, Zhu Shi

   pp. 137–146 · DOI: 10.5530/ijper.20272927 · 2027

   Background: Osteoarthritis is a degenerative joint condition defined by the destruction of cartilage, resulting in pain, stiffness, and impaired joint function. There is a growing need for safe and effective therapies th…

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7. Article

   Development and Assessment of Mucoadhesive Buccal Tablets Containing Dapsone: A Pharmaceutical Innovation

   Kondapuram Parameshwar, Raghavendra Kumar Gunda, Shaik Harun Rasheed, Venugopal Muralidharan, K Ravi Shankar

   pp. 140–149 · DOI: 10.5530/ijper.20266059 · 2026

   Objectives: This research involved developing buccal tablets with the drug Dapsone, using varying amounts of three substances: Carbopol 934, Hydroxypropyl Methylcellulose, and Sodium Carboxymethyl Cellulose. Materials an…

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8. Article

   Nephroprotective Effects of Sarsasapogenin in Adenine-Induced Chronic Kidney Failure in Experimental Rats

   Zhenzhen Hao, Minhua Xiao, Yan Gao, Qian Wang, Jing Li, Li Guo

   pp. 147–155 · DOI: 10.5530/ijper.20273235 · 2027

   Background: Chronic Kidney Disease (CKD), characterized by a progressive decrease in kidney function, has become a prominent health issue worldwide. The limitations of existing therapeutics for CKD underscore the pressin…

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9. Article

   Design and Characterization of Camptothecin Loaded Colloidosomes for the Effective Treatment of Lung Cancer

   Swapnil Harale, Kaivalya Mirajakar, Sunil Galatage, Arehalli Manjappa, Mrityunjaya Patil, Kishori Sutar, Rushikesh Katkar, Durgacharan Bhagwat, Lakshmanarao Potti, Rahul Trivedi, Gourisankar Kandukuri, Prajyot Kumbhar, Kranti Bille, Ankush Patil

   pp. 150–162 · DOI: 10.5530/ijper.20260528 · 2026

   Background: Among the various cancers, lung cancer is the second leading cause of mortality after the breast carcinoma. Camptothecin (CPT) has broad spectrum anticancer potential used in the effective management of cance…

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10. Article

    Investigating the Multimodal Mechanism of a Polyherbal Anti-Diabetic Preparation Using 3T3-L1 adipocytes, C2C12 myotubes, and βTC-6 β-Cell Line Models

    Venkatesh Uppara, Bachu Venkata Ramana

    pp. 156–168 · DOI: 10.5530/ijper.20273955 · 2027

    Introduction: Hyperglycaemia is a complicated condition that includes reduced production of insulin, resistance towards insulin, and oxidative imbalance. Current therapies often have limited efficacy and adverse effects,…

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11. Article

    Chrysin Ameliorates Mycoplasma pneumonia Induced Pneumonia in Mice by Down-Regulating Inflammatory Response

    Qiong Gao, Jiao Jiao, Tian Tian, Yanping Shi, Jun Li

    pp. 163–171 · DOI: 10.5530/ijper.20261592 · 2026

    Background: Mycoplasma pneumonia, a major respiratory infection characterized by inflammation of the lungs, poses a substantial global health concern, particularly among vulnerable populations such as the elderly, immuno…

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12. Article

    Exploring the Molecular Mechanisms of Senegenin in Lung Cancer via PI3K/AKT/mTOR Pathway and Computational Docking Studies

    Xinxiang Xu

    pp. 169–179 · DOI: 10.5530/ijper.20274380 · 2027

    Background: Lung cancer is a pervasive global malignancy that stands as a foremost cause of cancer-induced fatalities, defined by its heightened intratumor heterogeneity and the intricate nature of its cellular pathology…

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13. Article

    Anticancer Effects of Silver Nanoparticles Synthesized from Eupatorium adenophorum Extract in Animal Model: Impact on Tumor Growth, Apoptotic Markers and Organ Biomarkers

    Shilpa Rana, Uddipak Rai, Vineet Kumar, Pankaj Pant, Yogita Ale

    pp. 172–182 · DOI: 10.5530/ijper.20261036 · 2026

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14. Article

    Bergenin Inhibits Cell Viability and Induces Apoptotic Cell Death in Leukemia MOLT-4 Cells

    Lu Yan, Yiyang Li, Cuiyu Han, Rui Gao, Sining Xing, Jie Yang

    pp. 180–189 · DOI: 10.5530/ijper.20274774 · 2027

    Background: Leukemia, a hematological malignancy resulting from impaired blood cell formation in the bone marrow, is a considerable global health challenge, inflicting major burdens on individuals and healthcare systems.…

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15. Article

    Evaluation of Polyherbal Preparation Containing Aegle marmelos and Saraca asoca Plants for Screening of Urolithiasis Disease

    Pooja Pooja, Avijit Mazumder, Saumya Das

    pp. 183–190 · DOI: 10.5530/ijper.20261403 · 2026

    Aim: To evaluate the efficacy of a polyherbal formulation in alleviating urolithiasis induced by ethylene glycol in a rat model and to assess its effects on biochemical and histopathological parameters. Background: Uroli…

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16. Article

    Design, Development and Evaluation of Polyherbal Antimicrobial Discs Using Semisolid Extrusion Based 3D Printing Technology

    Suhasini Boddu, Karthikeyan Ramadoss, Kiranmai Mandava, Prakash Katakam

    pp. 190–199 · DOI: 10.5530/ijper.20272123 · 2027

    Background: 3D printing holds great promise for the development of innovative, individualised approaches to the distribution of medicinal products. The use of 3D printing to create objects with antibiotics has many advan…

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17. Article

    Osthenol Shows Cardioprotective Activity Against Isoproterenol-Induced Myocardial Infarction in Rats via Inhibiting Oxidative Stress and Inflammation

    Liu Wei, Wen Quanbao

    pp. 191–199 · DOI: 10.5530/ijper.20261966 · 2026

    Background: Myocardial Infarction (MI) is a devastating cardiovascular complication that develops when blood flow to a region of the myocardium is obstructed, resulting in cardiomyocyte necrosis and loss of contractile f…

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18. Article

    Isorhamnetin Attenuates Hyperglycemia-Induced Diabetic Nephropathy-Like Alterations in Human Embryonic Kidney Cells (HEK-293): In vitro Insights into the Potential Role of FOXO1

    Lin Zhang, Meilan Zhou, Amirah Albaqami, Omar Oraibi, Mohammed Somaili, May Mireani

    pp. 200–211 · DOI: 10.5530/ijper.20274613 · 2027

    Background: Diabetic nephropathy is becoming an alarming concern globally as the percentage of patients is increasing day by day. Although the suffering rate was too high, the existing treatment was very limited and non-…

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19. Article

    Protective Effects of Cassia fistula Linn. On Reproductive Organs Weight and Tissue Biochemical Markers in Streptozotocin-Induced Diabetic Male Rats

    Ram Niwas Jangir, Gyan Chand Jain, Aditya Jain

    pp. 200–208 · DOI: 10.5530/ijper.20261582 · 2026

    Objectives: This study aims to evaluate the impact of hydroethanolic extract from Cassia fistula pods on reproductive organs weight and biochemical markers within reproductive tissues in experimental diabetic rats. Mater…

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20. Article

    Effect of Carvacrol in Attenuating the TNF-α Induced Sarcopenia

    Ali Mufraih Albarrati, Rakan Ibrahim Nazer

    pp. 209–218 · DOI: 10.5530/ijper.20262945 · 2026

    Background: Sarcopenia is a condition characterized by muscle loss, which is accompanied by inflammation, oxidative stress, and mitochondrial dysfunction. The current treatment of sarcopenia is insufficient in handling t…

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