Volume 60, Issue 1

Original Article(continued)

1. Article

   Analgesic Activity of Gold Nanoparticles Biosynthesis and Analgesic Activity of Gold Nanoparticles (AuNPs) From Leaf Extract of Ziziphus zizyphus for Pain Management

   Shihan Fu

   pp. 212–221 · DOI: 10.5530/ijper.20270807 · 2027

   Aim/Background: The growing need for novel methods of preparing nanoparticles is evident in recent scientific pursuits. Environmental concerns about the security of current production processes are growing along with int…

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2. Article

   Development and Characterization of Catechin-Loaded Self-Nanoemulsifying Drug Delivery System: Pharmacokinetics, Toxicity Assessment, and in vivo Anti-Ulcer Activity Evaluation

   Rashmi Pathak, Phool Chandra

   pp. 219–236 · DOI: 10.5530/ijper.20261584 · 2026

   Purpose: This research aimed to prepare catechin-loaded SNEDDS that would improve the oral therapeutic efficacy of catechin. Materials and Methods: Catechin-SNEDDS was prepared and characterized using emulsification time…

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3. Article

   In vitro Investigation of Conessine-Mediated Apoptosis on Human Breast Cancer Cell Line (MCF-7) via Mitochondrial Pathway and APAF-1 Gene

   Ahad Amer Alsaiari, Hanadi M Zbrmawi, Jawaher Amer Alsaiari, Mariam M Jaddah, Aisha Abdullah Alshanqiti, Amal Saeed Al Ayed, Hanan Salem Alghamdi

   pp. 222–230 · DOI: 10.5530/ijper.20274669 · 2027

   Background: Breast cancer was the second most deadly cancer, especially in women. Recent data show that the incidence rate has been slowly rising over time and now it is becoming a global problem. This increasing problem…

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4. Article

   Effect of Baicalin on Placental Tissue Damage in Preeclampsia Rats via the IL-33/ST2 Pathway

   Shuyun Ding, Li Li, Feiyun Jiang, Yifan Mao

   pp. 231–239 · DOI: 10.5530/ijper.20271063 · 2027

   Objectives: To investigate the effect of baicalin on placental tissue injury in Preeclampsia (PE) rats and its possible mechanism. Materials and Methods: The caudal arterial blood pressure of Ed 1 5 and Ed 2 1 rats was d…

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5. Article

   Effect of Theobroma cocoa Extract on Olanzapine-Induced Metabolic Syndrome in Rats

   Varsha Patole, Sanjay Bhawar, Santosh Dighe, Rajashree Ghogare, Manisha Sonawane

   pp. 237–246 · DOI: 10.5530/ijper.20261703 · 2026

   Objectives: This study examined the effects of Theobroma cocoa hydro-alcoholic Extract (TCE) on the metabolic syndrome that rats developed because of olanzapine. Materials and Methods: Dry cocoa powder was macerated in 8…

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6. Article

   Pueraria lobate Leaf Extract Inhibits the P13K/AKT and MAPK/STAT3/NF-κB Signaling Pathways on Lung Carcinoma Cells

   Jingjian Zhang, Ying Cui, Ling Yang, Yan Lv

   pp. 240–247 · DOI: 10.5530/ijper.20271514 · 2027

   Background: Lung Cancer (LC) is the foremost cause of worldwide cancer-related mortalities, principally, Non-Small Cell Lung Cancer (NSCLC). Pueraria lobata (PL) is a prominent traditional Chinese edible remedial plant t…

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7. Article

   Anti-nociceptive and Anti-inflammatory Effects of Withanone in Various Nociception and Inflammation-Induced Murine Model

   Fengfeng Wang, Yunxia Zhu

   pp. 247–257 · DOI: 10.5530/ijper.20261166 · 2026

   Background: Pain is an unpleasant sensation that may result from severe or harmful stimuli. It serves as an indication that there may be a problem within the body and it can aid in ensuring the protection. Pain is a ubiq…

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8. Article

   Armepavine Ameliorates Acetaminophen-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammation

   Yanling Guo, Zhongting Pan

   pp. 248–256 · DOI: 10.5530/ijper.20273298 · 2027

   Objectives: The liver is an essential organ that plays a vital role in detoxification and protection against harmful chemicals and toxicants. Nursing care for patients with liver disorders needs a comprehensive understan…

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9. Article

   Exploring the Role of Proanthocyanidins in Mitigating Ulcerative Colitis in Mice

   Shaoqiang Sun, Yingde Wang

   pp. 257–265 · DOI: 10.5530/ijper.20271066 · 2027

   Aim: To determine the role of Proanthocyanidins (Pros) in mitigating Ulcerative Colitis (UC) in mice. Materials and Methods: A UC mouse model was constructed using dextran sulfate sodium induction in male adult Balb/c mi…

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10. Article

    Neuroprotective Effect of Inula racemosa on Chronic Stress-Aluminum Chloride Induced Memory Deficits

    Bhagya Venkanna Rao, Kanimozhi Loganathan, Sushma Raju, Ramya Vasudev

    pp. 258–269 · DOI: 10.5530/ijper.20261730 · 2026

    Introduction: Alzheimer's Disease (AD) is characterized by cognitive impairment resulting from the accumulation of amyloid beta and tau plaques, reduced Brain-Derived Neurotrophic Factor (BDNF) expression, neuronal death…

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11. Article

    Moringa oleifera Leaf Extract-Mediated Suppression of Epithelial to Mesenchymal Transition

    Samrat Paul, Anuradha Moirangthem, Nilanjana Ghosh, Sohini Sen, Sanjib Ray, Piyali Basak, Anupam Basu

    pp. 266–273 · DOI: 10.5530/ijper.20274154 · 2027

    Background: The increasing incidence of breast cancer remains a major global health challenge despite notable progress in diagnosis and therapy. Many patients progress to metastatic stages, where current treatments are n…

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12. Article

    Solid Lipid Nanoparticles of Resveratrol: Formulation, Characterization and In vitro Anti-Inflammatory Studies

    Vedanshu Malviya, Altaf Khan, Sachin Padole, Vaibhav Thakare, Tushar Gajbhiye

    pp. 270–282 · DOI: 10.5530/ijper.20261895 · 2026

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13. Article

    Network Pharmacology and Molecular Docking Combined with in vitro α-Amylase and α-Glucosidase Assays to Assess Anti-diabetic Properties of Curcuma longa

    Xuan Liu, Minhua Tan, Yanling Ren, Yani Wang

    pp. 274–285 · DOI: 10.5530/ijper.20273728 · 2027

    Background: This study investigates the antidiabetic effects of Curcuma longa extract using in vitro enzyme assays, network pharmacology, and in silico molecular docking to elucidate its molecular mechanisms. Materials a…

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14. Article

    In vitro Anti-oxidant, Antimicrobial, in silico Molecular Docking Analysis, and Phylogenetic Analysis of Anoectochilus elatus

    Sathishkumar Muthusamy, Selvi Sellappan, Palanisamy Arulselvan, Abdullah A Alarfaj

    pp. 283–293 · DOI: 10.5530/ijper.20262104 · 2026

    Background: Medicinal plants have long been valued for their therapeutic properties, offering a rich reservoir of bioactive compounds. Across millennia, diverse cultures worldwide have developed intricate systems of trad…

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15. Article

    Rhazya stricta Targets Proliferation/Apoptosis/ Inflammation Axis in Osteoarthritis: A Comprehensive Network Pharmacology Based Experimental Validation Study

    Hui Xu, Qiuming Zhou, Jinming Lu, Hao Zhang

    pp. 286–297 · DOI: 10.5530/ijper.20272382 · 2027

    Background: Osteoarthritis (OA), a degenerative joint disorder, demands multi-target therapeutic strategies. Rhazya stricta, a traditional medicinal plant, was explored for its phytochemicals and their anti-OA potential.…

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16. Article

    Antioxidant and Anti-Inflammatory Efficacy of Dipsacoside B in Ameliorating Myocardial Infarction in an in vivo Model

    Xiao Han, Fang Chen, Jinying Zhao

    pp. 294–304 · DOI: 10.5530/ijper.20262103 · 2026

    Background: Myocardial Infarction (MI) is a severe coronary ailment associated with a great risk of mortality, often contributing to sudden cardiac death. Cardiovascular diseases account for approximately 32% of global d…

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17. Article

    Bacoside A Averts Oxidative Stress and Inflammation in Pulmonary Disease Induced by Cigarette Smoke in Rats Through NRF2/ATF4 and TLR4/NF-κB Signaling Pathways

    Lan Wang, Di Wang, Qingli Yao

    pp. 298–307 · DOI: 10.5530/ijper.20272482 · 2027

    Background: Chronic Obstructive Pulmonary Disease (COPD) has emerged as a foremost cause of worldwide illness. Exposure to Cigarette Smoke (CS) contributes to Oxidative Stress (OS) and inflammation, which is a chief caus…

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18. Article

    Morpho-Genetic Variability in Phytochemical Composition and Essential Oils of Three Common Lavandula Species Cultivated in Van, Türkiye

    Lutfi Nohutcu, Murat Tuncturk, Ruveyde Tuncturk, Ezelhan Selem

    pp. 305–311 · DOI: 10.5530/ijper.20261158 · 2026

    Background: Lavandula sp. is a valuable plant species as ornamental plant with beautiful inflorescence and aromatic plant with high yield of essential oil. Lavender is mostly produced in Europe, the Middle East, Asia, No…

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19. Article

    In silico and in vitro Evaluation of Microwave-Assisted Synthesized Isoxazole Chalcone Derivatives of Selected Phytoconstituents for Antidiabetic Activity

    Shubhangi Sutar, Radhika Shinde, Sachin Mali, Rachana Bhimanwar, Sandeep Patil, Sopan Nangare

    pp. 308–323 · DOI: 10.5530/ijper.20272380 · 2027

    Background: Diabetes is a major chronic health problem worldwide that has acquired significant attention from the scientific community. One approach to managing glucose synthesis and reducing the risk of diabetes is thro…

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20. Article

    Monoterpene Α-Pinene Alleviates Diabetic Retinopathy in Rodent Model via Attenuating Hyperglycemia Induced VEGF Signaling

    Xiao Dong, Zhanrong Zhang

    pp. 312–321 · DOI: 10.5530/ijper.20261413 · 2026

    Background: Diabetic Retinopathy (DR) has emerged as a significant global health issue that requires urgent and collaborative action to tackle. As the leading causes of preventable blindness, DR predominantly impacts adu…

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