Volume 60, Issue 1S

Research Article

1. Article

   The Role of EPAC in the Pathogenesis of Cardiovascular Complications: A Review

   Nandini Dubey, Vishal Kumar Vishwakarma, Aanchal Verma, Ahsas Goyal, Harlokesh Narayan Yadav

   pp. s1–s10 · DOI: 10.5530/ijper.20260398 · 2026

   Cardiovascular disease is a primary cause of mortality and disability and it has long been a focus of clinical and scientific investigation. There is still much to learn about the intricate pathophysiology of cardiovascu…

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2. Article

   Global Comparison of Gene and Cell Therapy Regulations: A Cross-Regional Analysis of FDA, EMA, TGA, CSFDA, DCGI, PMDA, IFDA and MFDS

   Seyed Heidar Mohammadi, Gholamhossein Sadeghian, Hoseein Shomali, Mohamadreza Abedi, Behrooz Jannat, Faham Khamesipour

   pp. s18–s32 · DOI: 10.5530/ijper.20260001 · 2026

   Gene and cell therapies mark a transformative step forward in treating diseases such as cancer, genetic disorders and autoimmune conditions. However, regulatory pathways for these therapies differ worldwide, impacting ap…

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3. Article

   Review on Exploring the Combination Effect of Aldosterone along with Plasma Renin with Melatonin and Hydro-Cortisol in Diurnal Rhythm

   Mainak Pal, Masud Sk, Saheli Mandal, Dipanjan Mandal

   pp. s33–s41 · DOI: 10.5530/ijper.20260468 · 2026

   Aldosterone and plasma renin activity play a role in regulating our blood stress and fluid level while melatonin and cortisol help manage our sleep wake cycles as well as our reaction to stress. These hormones go through…

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4. Article

   Regulatory Pathway for Genotoxic Impurities in Europe, US, Canada, India, Australia and UK

   Kavyashree Kadehalli Ramegowda, Sangita Mishra, Venkatesh Madhugiri Prakash

   pp. s42–s51 · DOI: 10.5530/ijper.20260762 · 2026

   Genotoxic Impurities (GTIs) pose a significant risk to pharmaceutical safety due to their ability to damage DNA and cause cancer-related mutations. Regulatory agencies such as the EMA, USFDA, Heath Canada, CDSCO and TGA …

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5. Article

   Project-Based Learning with Virtual Laboratories to Promote Higher-Order Thinking Skills to Achieve Competency in Chemical Separation

   Manihar Situmorang, Mita Mahrani, Hendra Simanjuntak, Jamalum Purba, Marudut Sinaga, Marham Sitorus, Ajat Sudrajat

   pp. s52–s64 · DOI: 10.5530/ijper.20260625 · 2026

   Background:Higher-order thinking skills become life skills for pharmacists and scientists that are needed in solving scientific problems and can be obtained through implementing appropriate learning models. Objectives: T…

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6. Article

   Enteric Coated Sustained Release Mucoadhesive Tablet of Metronidazole for Targeted Colon Delivery: A Formulation and Evaluation Study

   Latika Bisht, Mansi Butola, Assem Babbar, Abhijeet Ojha, Tarun Parashar, Yogita Ale, Shilpa Rana, Vikash Jakhmola

   pp. s65–s73 · DOI: 10.5530/ijper.20260414 · 2026

   Background: Colon-specific Drug Delivery Systems (CDDS) are useful for treating many localized conditions such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis and colonic cancer. In…

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7. Article

   Development and Optimization of Eletriptan Hydrobromide Sublingual Tablet Using Central Composite Design and in vitro Characterization

   Vaishali Raghuwanshi, Akanksha Dwivedi, Gajanan Darwhekar

   pp. S74–S82 · DOI: 10.5530/ijper.20265387

   Background: In the current research, the sublingual tablets were formulated by utilizing a solid dispersion by physical mixture technique using sodium starch glycolate works as a super disintegrant and cyclodextrin works…

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8. Article

   Formulation and Characterization of Clotrimazole Loaded Polymeric Nanoparticles Fabricated by Single Emulsion Evaporation Technique

   Valikala Viswanath, Palla Venkata Murali Krishna, Vankam Lokeswara Babu, Tanuja Anajigere Mruthunjaya Lakkamma

   pp. s83–s92 · DOI: 10.5530/ijper.20260603 · 2026

   Aim/background: Utilizing nanotechnology allows us to shrink machinery down to the atomic level, leading to groundbreaking progress in technical innovation. Our most recent efforts concentrated on developing polymeric na…

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9. Article

   Formulation, Characterization and Optimization of Transdermal Patches of Venlafaxine Hydrochloride Using 32 Full Factorial Approach

   Ashutosh Bansal, Navneet Garud, Ramakant Joshi, Rajendra Chauhan, Hemant Mourya, Pawan Kushwah, Trapti Sahu

   pp. s93–s100 · DOI: 10.5530/ijper.20265993 · 2026

   Introduction: The primary objective of the present investigation was to develop transdermal patches that would extend the half-life of Venlafaxine Hydrochloride and boost its bioavailability. Transdermal patches were mad…

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10. Article

    Formulation, Optimization and Evaluation of Barbaloin Loaded Phytosomal Gel for the Treatment of Psoriasis

    Mukesh Vinod Kapse, Jameel Ahmed Sayed Gous Mulla

    pp. s101–s111 · DOI: 10.5530/ijper.20260663 · 2026

    Background:Phytosomes are one such unique approach gaining popularity due to their capabilities in controlled release and targeted delivery. These advanced herbal formulations significantly enhance the bioavailability of…

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11. Article

    Fabrication and Characterisation of Azithromycin-Loaded Ethosomes as an Advanced Vesicular Carriers for Acne Therapy

    Abishek Kumar Anant Patil, Prashant Shivanand Halagali, Rahul Ramesh Koli, Nisha Shirkoli, Veerkumar Prakash Japti, Kishori Prasanna Sutar

    pp. s112–s123 · DOI: 10.5530/ijper.20260668 · 2026

    Aim: This study is aimed to design and evaluate azithromycin-loaded ethosomes as an innovative approach to address the limitations of conventional azithromycin topical dosage forms in the treatment of acne. Materials and…

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12. Article

    Development and Evaluation of Levofloxacin-Based In situ Floating Gel for Enhanced Gastric Retention

    Aniket Anand Nale, Priyanka Abaso Thorat, Jameel Ahmed Sayed Gous Mulla

    pp. s124–s135 · DOI: 10.5530/ijper.20260759 · 2026

    Background: This work focuses on the development and testing of a floating in situ gel system based on sodium alginate that delivers levofloxacin to treat stomach Helicobacter pylori infections. Materials and Methods: As…

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13. Article

    Leveraging Factorial Design for Enhancing Formulation of Ketorolac Tromethamine Fast-Disintegrating Tablets

    Suryaprakash Reddy Chappidi, Deepa Mopuri

    pp. s136–s144 · DOI: 10.5530/ijper.20260504 · 2026

    Aim: Fast disintegrating tablets of Ketorolac tromethamine were prepared by formulating it with various super disintegrants with view to reduce disintegration time of tablets and to increase dissolution properties. Mater…

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14. Article

    Development and Statistical Optimization of Aquasomes Containing Ketoprofen: 2-Factor 2-Level Factorial Design Approach

    Megha Pudukulam Mana, Sivakumar Ramakrishnan

    pp. s145–s150 · DOI: 10.5530/ijper.20260916 · 2026

    Purpose: The purpose of the research work was to develop Aquasomes containing Ketoprofen (AQ-KP) for enhanced stability of the drug with improved therapeutic effect. Materials and Methods: The aquasomes are formulated by…

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15. Article

    Pharmacokinetics Studies of Lurasidone Hydrochloride in Nano Structured Lipid Carrier Formulation for Nasal to Brain Delivery

    Tanvi Kadam, Surendra Agrawal, Saritha Shetty

    pp. s159–s167 · DOI: 10.5530/ijper.20260543 · 2026

    Aim:Lurasidone Hydrochloride (LH) is a benzothiazole derivative used as an antipsychotic drug for the treatment of schizophrenia. Oral administration of Lurasidone hydrochloride, however, results in low bioavailability a…

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16. Article

    Pulmonary Drug Delivery of Budesonide in the Form of Inhalable Microspheres

    Neha Padiyar, Vikash Jakhmola

    pp. s168–s175 · DOI: 10.5530/ijper.20261573 · 2026

    Objectives: Chronic Obstructive Pulmonary Disease (COPD) is a major healthcare issue that is rising and expected to increase in day-to-day life. Our research work focused on developing Dry Powder Inhaler (DPI) microspher…

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17. Article

    Evaluation of Anti-Tumour Efficacy of Liposomes Loaded with Rubitecan as Potential Antitumor Drug Delivery System

    Farsiya Fatima, Munuswamy Komala

    pp. s176–s183 · DOI: 10.5530/ijper.20264331 · 2026

    Aim:The present research objective was to characterize the prepared liposomes for in vitro cytotoxicity assay, cellular uptake studies of liposomes, competitive binding assay and hemolytic test. Materials and Methods:The…

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18. Article

    Investigating the α-Amylase Inhibitory Effects of Adansonia digitata L.: A Comprehensive in vitro and Computational Study

    Shirish Sidgonda Patil, Suresh Ganpati Killedar

    pp. s184–s193 · DOI: 10.5530/ijper.20261273 · 2026

    Background: The study explores Adansonia digitata L.s potential in diabetes management through phytochemical and protein analyses. Materials and Methods:Eight identified phytoconstituents, comprising alkaloids, terpenes …

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19. Article

    Protective Effects of Petroselinum crispum Ethanolic Extract Against D Galactose and Aluminum Chloride Induced Alzheimers Disease in Rats A Behavioral and Biochemical Approach

    P Aswin, G Sivakumar

    pp. s194–s204 · DOI: 10.5530/ijper.20263885 · 2026

    Background: Alzheimer’s disease is one of the progressive neurodegenerative disorders affecting the elderly population without a clear etiology, accounting for more than 80% of dementia worldwide. We found the D-Gal and …

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20. Article

    Probe Sonication-Based Green Synthesis AgNPs Using P. Guajava Leaves Extract and Anticancer Behavior MCF-7 Cell Lines

    Abhishek Singh, Vikash Jakhmola, Naveen Chandra Joshi, Tarun Parashar

    pp. s205–s211 · DOI: 10.5530/ijper.20261382 · 2026

    Purpose: The present work is devoted to the green and probe sonication-based fabrication of AgNPs using the leaves extract of P. guajava.Materials and Methods: Various analytical techniques have been used to characterize…

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