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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Nephroprotective effect of Dichrostachys cinerea Bark Extract against Streptozotocin Induced Diabetic Nephropathy Via Alteration of Oxidative Stress and Inflammation

Kavitha Kandasamy1, Zain Alabden Ghanim Ahmed Ahmed2, Zead Helmi Abudayeh3, Samer Hasan Hussein-Al-Ali4, Shilpa Perumal Narasimhamoorthi5, Palanisamy Arulselvan6, Karunakaran Saravanan7, Subbarayan Sarathbabu8★★ Corresponding author

  1. 1Department of Biochemistry, Vivekanandha College of Arts and Sciences for Women, Tiruchengode, Namakkal, Tamil Nadu, INDIA.
  2. 2College of Pharmacy, Al-Kitab University, Kirkuk, IRAQ.
  3. 3Basic Pharmaceutical Sciences Department, Faculty of Pharmacy, Isra University, Amman, JORDAN.
  4. 4Department of Chemistry, Faculty of Sciences, Isra University, Amman, JORDAN.
  5. 5Centre for Applied Research, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, INDIA.
  6. 6Department of Biochemistry, Karpagam Academy of Higher Education (Deemed to be University), Coimbatore, Tamil Nadu, INDIA.
  7. 7Department of Chemical Engineering, KPR Institute of Engineering and Technology, Avinashi Road, Arasur, Coimbatore, Tamil Nadu, INDIA.
  8. 8Muthayammal Centre for Advanced Research, Muthayammal College of Arts and Science, Rasipuram, Namakkal, Tamil Nadu, INDIA.

CORRESPONDENCE

Subbarayan Sarathbabu

Muthayammal Centre for Advanced Research, Muthayammal College of Arts and Science, Rasipuram, Namakkal, Tamil Nadu, INDIA.

sarath07bio@gmail.com

Received: 06-04-2026; Revised: 21-05-2026; Accepted: 14-07-2026.

Volume 60, Issue 4 · pp. 1720–1729 · PUBLISHED 2026 · DOI: 10.5530/ijper.20264263

View on IJPER original site ↗

ABSTRACT

Introduction: The primary trigger of End-Stage Renal Disease (ESRD) in several affluent nations, including the US, is diabetic nephropathy. Objectives: Diabetic nephropathy is a microvascular consequence that can occur in patients with Type 1 Diabetes (T1D) or Type 2 Diabetes (T2D). Because of its anti-inflammatory and antioxidant effects, Dichrostachys cinerea (L.) Wight and Arn. (DC) treats many inflammatory diseases, especially rheumatoid arthritis. Materials and Methods: The experimental rats were given an intraperitoneal dose of 60 mg/kg of STZ to cause diabetes. Following diabetic induction, fasting blood glucose samples were taken on the 0thand 30th day. Following the study, we evaluated the activity of pro-inflammatory indicators, renal biochemical markers, and levels of oxidative and antioxidant stress following DCBE treatment. Results: Glibenclamide is an anti-diabetic medication that was utilized in the study to compare treatment with DCBE. When DCBE was administered to STZ-induced diabetic rats, the levels of ROS, plasma AGEs, BUN, Serum Creatinine, uric acid, NAG, and U-mAIb were found to decrease. TNF-α, IL-1β, and IL-6 activities were all markedly downregulated. Following DCBE treatment, SOD, GSH, and GPx levels increased. Conclusion: According to the current investigation, DCBE treatment alleviated STZ-induced diabetes in a manner comparable to that of glibenclamide treatment. It might therefore be utilized as a possible treatment for diabetic nephropathy in the future.

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    Kandasamy, K., Ahmed, Z. A. G. A., Abudayeh, Z. H., Hussein-Al-Ali, S. H., Narasimhamoorthi, S. P., Arulselvan, P., Saravanan, K., & Sarathbabu, S. (2026). Nephroprotective effect of Dichrostachys cinerea Bark Extract against Streptozotocin Induced Diabetic Nephropathy Via Alteration of Oxidative Stress and Inflammation. Indian Journal of Pharmaceutical Education and Research, 60(4), 1720–1729. https://doi.org/10.5530/ijper.20264263