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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Evaluation of the Protective Efficacy of Nigella sativa Oil with Some Hematological Parameters and ANAE Positive Lymphocyte Ratio in Bisphenol A Toxicity

Mehmet Özsan1★, İlknur Ündağ2, Nurcan Dönmez3, Elif Aydın2, Hasan Hüseyin Dönmez2★ Corresponding author

  1. 1Department of Physiology, Faculty of Medicine, Niğde Ömer Halisdemir University, Niğde, TÜRKIYE.
  2. 2Department of Histology and Embryology, Faculty of Veterinary Medicine, Selçuk University, Konya, TÜRKIYE.
  3. 3Department of Physiology, Faculty of Veterinary Medicine, Selçuk University, Konya, TÜRKIYE.

CORRESPONDENCE

Mehmet Özsan

Department of Physiology, Faculty of Medicine, Niğde Ömer Halisdemir University, Niğde, TÜRKIYE.

mehmetozsan@ohu.edu.tr

Received: 06-04-2026; Revised: 11-06-2026; Accepted: 24-07-2026.

Volume 60, Issue 4 · pp. 1730–1735 · PUBLISHED 2026 · DOI: 10.5530/ijper.20263488

View on IJPER original site ↗

ABSTRACT

Background and Aim: Bisphenol A (BPA) est chemicum endocrinum perturbans, late in variis productis consumptoriis adhibitum, quod per systemata endocrinum et immunologicum nocet valetudini. Huius studii propositum erat explorare effectus expositionis ad BPA in parametris hematologicis et responsione immunitaria in muribus Wistar Albino, simulque aestimare potentiam protectivam olei seminis Nigella sativa (N. sativa), noti ob proprietates antioxidanticas et antiinflammatorias. Materials and Methods: In hoc studio, triginta mures masculi Wistar Albino in quattuor coetus divisi sunt: Control, BPA, N. sativa, et BPA+N. sativa. Per quattuor hebdomadas experimenti, coetibus BPA et BPAN quotidie data est dosis 100 mg/kg BPA, dum oleum essentiale N. sativa coetibus NS et BPAN per os datum est ad dosim 5 mL/kg. Post tempus curationis, parametri hematologici quidam et proportio lymphocytorum ANAE-positivorum sunt examinati. Results and Discussion: Expositio ad BPA significanter reduxit numerum erythrocytorum, gradum hemoglobini, valorem hematocriticum, numerum thrombocytorum et proportionem lymphocytorum ANAE-positivorum, ducens ad anemia et debilitamentum systematis immunis. In coetu BPAN, hi parametri valores maiores ostenderunt comparati ad coetum BPA, indicantes meliorationem. Conclusion: Inventiones studii suggerunt oleum N. sativa posse habere effectum protectivum contra toxicitatem inductam a BPA, etiam antequam apparent symptomata clinica. Observatae sunt emendationes in parametris hematologicis, quae indicant potentiam huius plantae in praeventione damni immunologici et hematologici.

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    Özsan, M., Ündağ, L., Dönmez, N., Aydın, E., & Dönmez, H. H. (2026). Evaluation of the Protective Efficacy of Nigella sativa Oil with Some Hematological Parameters and ANAE Positive Lymphocyte Ratio in Bisphenol A Toxicity. Indian Journal of Pharmaceutical Education and Research, 60(4), 1730–1735. https://doi.org/10.5530/ijper.20263488