Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery
Jaydeep Patel1★, Garala Kevin1, Anjali Patel2, Mihir Raval3, Navin Sheth3★ Corresponding author
- 1Department of Pharmaceutics, Atmiya Institute of Pharmacy, Kalawad Road.
- 2Smt. R. D. Gardi B. Pharmacy College, Nyara.
- 3Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, INDIA.
CORRESPONDENCE
Jaydeep Patel
Department of Pharmaceutics, Atmiya Institute of Pharmacy, Kalawad Road.
Received: 11-01-2011; Revised: 21-02-2011; Accepted: 02-02-2011.
Volume 1, Issue 2 · pp. 112–118 · PUBLISHED · DOI: 10.4103/2230-973X.82431
ABSTRACT
Background and Aim: Telmisartan (TEL) is an angiotensin II receptor blocker (ARB) antihypertensive agent. The aim of the present investigation was to develop a self-nanoemulsifying drug delivery system (SNEDDS) to enhance the oral bioavailability of poorly water soluble TEL. Materials and Methods:The solubility of TEL in various oils was determined to identify the oil phase of a SNEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify the selected oil. Pseudoternary phase diagrams were constructed to identify the efficient self-emulsifying region. A SNEDDS was further evaluated for its percentage transmittance, emulsification time, drug content, phase separation, dilution, droplet size, zeta potential, pH, refractive index, and viscosity. Results:The developed SNEDDS formulation contained TEL (20mg), Tween® 20 (43.33%w/w), Carbitol® (21.67%w/w), and Acrysol® EL 135 (32%w/w). The optimized formulation of the TEL-loaded SNEDDS exhibited a complete in vitro drug release in 15min as compared with the plain drug, which had a limited dissolution rate. It was also compared with the pure drug suspension by oral administration in male Wister rats. The in vivo study exhibited a 7.5-fold increase in the oral bioavailability of TEL from the SNEDDS compared with the pure drug suspension. Conclusions:These results suggest the potential use of the SNEDDS to improve the dissolution and oral bioavailability of poorly water soluble TEL.
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Patel, J., Kevin, G., Patel, A., Raval, M., & Sheth, N. (). Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery. International Journal of Pharmaceutical Investigation, 1(2), 112–118. https://doi.org/10.4103/2230-973X.82431