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International Journal of Pharmaceutical InvestigationNOW IN
Article

Preparation of poly(NIPAAm)-Pluronic F68 as a thermosensitive surfactant for a controlled drug release

Sung-Wook Choi1, Hye Min Lee2, Tae-Joon Park2, Jung-Hyun Kim2★★ Corresponding author

  1. 1Division of Biotechnology, The Catholic University of Korea, Gyeonggi-do 420-743.
  2. 2Department of Chemical Engineering, Yonsei University, Seoul 120-749, SOUTH KOREA.

CORRESPONDENCE

Jung-Hyun Kim

Department of Chemical Engineering, Yonsei University, Seoul 120-749, SOUTH KOREA.

jayhkim@yonsei.ac.kr

Received: 14-12-2010; Revised: 06-01-2011; Accepted: 12-01-2011.

Volume 1, Issue 2 · pp. 88–92 · PUBLISHED · DOI: 10.4103/2230-973X.82402

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ABSTRACT

This paper describes the synthesis of thermosensitive surfactants by polymerizing N-isopropylacrylamide (NIPAAm) into the Pluronic F68 surfactant and their application for a controlled drug release. Poly(NIPAAm)-Pluronic surfactants with different lengths of the NIPAAm block were synthesized by activating two hydroxyl groups of poly(ethylene oxide) (PEO) at the end of Pluronic F68 using cerium ammonium nitrate (CAN, redox initiator), followed by adding the NIPAAm monomer into a reactor. The resultant poly(NIPAAm)-Pluronic surfactants were characterized by FT-IR and gel filtration chromatography (GPC). It was observed that their critical micellar concentrations increased with an increase in the length of the poly(NIPAAm) block. In addition, poly(d,l-lactide-co-glycolide) (PLGA) microparticles was prepared by an oil-inwater emulsion and solvent evaporation method using the poly(NIPAAm)-Pluronic surfactants in an aqueous continuous phase. At 37°C, nile red (model dye) was released from the PLGA microparticles in a more sustained manner when the length of poly(NIPAAm) was longer due to a thicker layer of shrunken poly(NIPAAm) at the surface of the microparticles.

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    Choi, S., Lee, H. M., Park, T., & Kim, J. (). Preparation of poly(NIPAAm)-Pluronic F68 as a thermosensitive surfactant for a controlled drug release. International Journal of Pharmaceutical Investigation, 1(2), 88–92. https://doi.org/10.4103/2230-973X.82402