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International Journal of Pharmaceutical InvestigationNOW IN
Article

Effect of agar—gelatin compositions on the release of salbutamol tablets

Anita Saxena1, Abu Tahir2, Mandeep Kaloti1, Javed Ali2, Himadri B Bohidar1★★ Corresponding author

  1. 1School of Physical Sciences, Nanomaterials and Nanocomposites Laboratory.
  2. 2Jawaharlal Nehru University, 1 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, INDIA.

CORRESPONDENCE

Himadri B Bohidar

School of Physical Sciences, Nanomaterials and Nanocomposites Laboratory.

bohi0700@mail.jnu.ac.in

Received: 06-12-2010; Revised: 10-12-2010; Accepted: 06-01-2011.

Volume 1, Issue 2 · pp. 93–98 · PUBLISHED · DOI: 10.4103/2230-973X.82407

View on IJPI original site ↗

ABSTRACT

The study was designed for the development of salbutamol-modified release tablet using various polymer composition of agar, gelatin A and gelatin B. The purpose is to observe the role of polymer composition on the modified dissolution rate of salbutamol. Pre-formulation trials were initiated by comprising different ratios of polymer blend in the tablets. Formulations were optimized based on their invitro release performed in enzyme free simulated gastric fluid (0.1 N HCl, pH 1.2). Dissolution profiles of tablets were compared among the tablets made of agar, gelatin A, gelatin B and their blends agar-gelatin A, agar-gelatin B, gelatin A-gelatin B and agar-gelatin A-gelatin B in 1:1 ratio. Polymer compositions were fixed based on our desired sustaining activity of the tablet which showed a biphasic release profile with immediate release followed by sustained release. Polymer blends were more effective in controlling drug release. The better controlling behavior of polymer blends was explained by specific interaction between polymer components, their network structure and polymer–drug interaction.

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    Saxena, A., Tahir, A., Kaloti, M., Ali, J., & Bohidar, H. B. (). Effect of agar—gelatin compositions on the release of salbutamol tablets. International Journal of Pharmaceutical Investigation, 1(2), 93–98. https://doi.org/10.4103/2230-973X.82407