Formulation Development of Celecoxib Loaded Microsponges using Eudragit and Ethyl Cellulose

ABSTRACT

Background:Microsponge is a class of dosage form containing porous nature containing drug that is targeted to achieve sustained action for prolong period. Microsponge based delivery system results in drug localization on skin surface and in epidermis without moving in systemic circulation to higher extent. Methods: Present study aims to formulate the microsponge containing celecoxib by quasi emulsification solvent diffusion method. Prepared formulations were evaluated for particle size, % entrapment efficiency, production yield, surface morphology, etc. Results:Formulation F1 and E2 were considered as optimized formulation having drug loading 91±4.2 % and 91±3.1 % respectively. FTIR spectroscopy analysis indicated the chemically stable, crystalline nature of the drug in these microsponges. Small change in crystallinity of pure drug was observed in XRD study. SEM study shows good microsponge surface appearance with pores on surfaces. Average particle size of optimized microsponge formulation F1 is found to be 48 µm while E2 formulation gave microsponges with particle size of 33.7 µm. As the RPM was increased the microsponge’s size was also decreased and formed microsponges were spherical and is having uniform nature. Conclusion:Finally it can be concluded that chemically stable, uniform and porous microspheres were formed using Eudragit L-100 and Ethyl cellulose.

KEYWORDS

• Celecoxib
• Quasi emulsification
• Eudragit
• Ethyl cellulose

Showing references and in-text citations exactly as published.

• DOI10.5530/ijpi.2021.2.40Copy

RELATED ARTICLES

Matched on section and article type within this issue of IJPI.

• Article · VOLUME 11, ISSUE 2Assessment of Antioxidant and Pancreatic Lipase Activity of Smilax zeylanica Roots: An in vitro AnalysisRosaline Mishra, Divya Juyal, Sadish Kumar Shanmugham · pp. 154–157Original ArticleSame type: Article
• Article · VOLUME 11, ISSUE 2Enzyme Inhibition Activity Both in vitro and in silico Screening of Triphala Plant Extracts on Phospholipase A2Satyanarayana Murthy Malladi, Nagendra Sastry Yarla, Devendra Kumar Pandey · pp. 158–164Original ArticleSame type: Article
• Article · VOLUME 11, ISSUE 2Hepatoprotective Potential of Methanolic and Aqueous Extract of Chenopodium botrys against Lead-induced ToxicityNidhi Gupta, Rakesh Sagar, Mohan Lal Kori · pp. 165–169Original ArticleSame type: Article
• Article · VOLUME 11, ISSUE 2Chemical Characterization, Antimicrobial, Antiproliferative and Antioxidant Activities of the Essential Oil of Monarda citriodora Growing in KashmirAbdul Rouf Wani, Kanchan Yadav · pp. 170–175Original ArticleSame type: Article