Alpha-Asarone Ameliorates Cisplatin Induced Hepatotoxicity via Reducing the Oxidative Stress in Experimental Animals

ABSTRACT

Background: The aim of present study was to find protective effect of α-asarone in cisplatin-induced hepatotoxicity in experimental rats. Materials and Methods: The rats were divided into 5 groups at randomly. Cisplatin was given at a dosage of 7.5 mg/kg to produce hepatotoxicity, and serum AST, ALT, total bilirubin, and albumin, as well as hepatic hydroxy proline (HP), reduced glutathione (GSH), and malondialdehyde (MDA), cytokines, and NO, were assessed. Finally, histological examination of liver tissue was performed (H&E staining). Results: Cisplatin treatment resulted in a reduction in body weight and a rise in liver weight in rats, while treatment with -asarone resulted in normal body and liver weight. Serum AST, ALT, total bilirubin, HP, GSH, MDA and cytokines were increased cisplatin rats. α-Asarone treated rats showed reduction in the oxidative stress as well as inhibited the release of cytokines in dose dependent manner and showed protection against hepatotoxicity. Cisplatin treated rat’s shows pathological tissue structure, while rats treated with α- asarone shows normal structure of liver tissue.Conclusion: The study concludes that, α-asarone has protective effect against the hepatotoxicity induced by Cisplatin.

KEYWORDS

• Cisplatin
• Hepatotoxicty
• ALT
• Oxidative stress
• α-Asarone
• Cytokine

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• DOI10.5530/ijpi.2022.1.12Copy

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