Volume 13, Issue 1

Abhishek Srivastava, Mohammad Ahmad Khan, Simrata Bedi, Uma Bhandari

pp. 1–6 · DOI: 10.5530/223097131574 · 2022

Ticagrelor is a BCS class IV drug that inhibits platelet action by reversibly binding to the P2Y12 receptor. One of the major challenges faced by the class IV (low solubility, low permeability) drug is the lower dissolut…

Indu Raghunath, Marina Koland, Anoop Narayanan Vadakkepushpakath, Lalit Kumar, Sarathchandran Chandra Shekhar Shenoy

pp. 7–13 · DOI: 10.5530/223097131736 · 2022

The oral delivery of protein and peptide drugs faces immense challenges due to the harsh gastrointestinal (GI) environment, large molecular size, and low stability. Even though different approaches are employed to delive…

Sandeep Grover, B.M. Gupta, K.K. Mueen Ahmed, Yogindra Singh

pp. 14–21 · DOI: 10.5530/223097130001 · 2022

Aim: This study evaluates the research output on Clozapine included in Scopus database during 1970-2021. Materials and Methods:The quantitative and qualitative analysis of publications on “Clozapine” covered in Scopus da…

Dara Suneeta, YRKV Tirupathi Rao

pp. 22–27 · DOI: 10.5530/223097131566 · 2022

Background:Ixora pavetta and Tecoma capensis are two less explored and neglected plants species in medicinal prospective. The flowers bark and root of I. pavetta used as a remedy for cough, anaemia, women urinary problem…

Sarika Nikam, Shilpa Chaudhari

pp. 28–36 · DOI: 10.5530/223097131651 · 2022

Objectives: Traditional method of optimization is lengthy and time consuming while response surface methodology evaluates the effects of multiple factors and their interactions on one or more response variables with fewe…

Machavarapu Neelima, Yekkala Prathyusha, Mamindla Archana, Thirunagiri Praveen kumar

pp. 37–42 · DOI: 10.5530/223097131669 · 2022

Introduction:Respiratory tract infection (RTI) is defined as any upper or lower respiratory tract infectious disease. Globally, respiratory infections are the leading cause of infant and child mortality and a substantial…

Mandar Ambike, Nabilah Kazi, Arun Prasad, Dnyandeo Chopade, Suresh Kondaveeti

pp. 43–47 · DOI: 10.5530/223097131714 · 2022

Background: A well-established finding is that thyroid disease is seen more commonly in individuals suffering from Down’s Syndrome than in people without the condition. Patients are at risk from childhood to adulthood. T…

Paviterjeet Singh, Shweta Singla, Rajiv Mahajan, Rakendra Singh, Manish Kumar Gupta

pp. 48–52 · DOI: 10.5530/223097131715 · 2022

Background: Adverse Drug Reactions (ADRs) are amongst the commonly occurring event in the intensive care unit where patients are mostly on the polypharmacy. They affect the quality of life of patients and increase the bu…

Supriya Bhowmick, Deblina Giri, Meghamala Mandal, Shrabanti Pyne, Pinku Pal, Sanjay Das, Dilip Kumar Nandi, Koushik Das

pp. 53–61 · DOI: 10.5530/223097131728 · 2022

Background:Chronic kidney disease is now a global burden with an increased grade of morbidity and mortality due to the unavailability of particular medicines except for high-cost treatments like dialysis or kidney transp…

Sunil Harer, Manish Bhatia, Priyanka Sonar

pp. 62–73 · DOI: 10.5530/223097131749 · 2022

Objectives:Substituted quinazolin-4(3H)-ones at position-3 with phenyl ring, heterocycles and aliphatic moieties, were reported to impart antimicrobial activities. In light of this, we have attempted to prepare a novel s…

Kinjal Patel, Keyur Patel, Maitreyi Zaveri

pp. 74–81 · DOI: 10.5530/223097131792 · 2022

Background:More than 85% of young people around the world suffer from acne vulgaris, which is the most prevalent chronic inflammatory skin illness. The study’s objective was to develop a herbal patch formulation containe…

Deepak K. Dwivedi, Ram Kishore Agrawal

pp. 82–86 · DOI: 10.5530/223097131793 · 2022

Background:Breast cancer is the highest mortality-causing disease among cancers in women and it can be cured by early diagnosis as well as treatment. Epidermal growth factor receptor-2 (HER2) is the prime factor that hel…

Pritish Kumar Panda, Sanjay K. Jain

pp. 87–93 · DOI: 10.5530/223097131799 · 2022

Objectives:Doxorubicin-bearing polymeric (PLGA) nanoparticles (PNPs) were prepared for the treatment of prostate cancer. Materials and Methods:These PNPs were prepared using the solvent evaporation method and characteriz…

Shivani Saraf, Priyanka Pahade, Devashish Bose, Sanjay K. Jain

pp. 94–99 · DOI: 10.5530/223097131802 · 2022

Objectives: This study aimed to develop a micellar liquid chromatography-based simultaneous estimation method for the analysis of topotecan and capsaicin. Materials and Methods:The Liquid chromatographic system consisted…

Laxmikant Gautam, Suresh P. Vyas

pp. 100–105 · DOI: 10.5530/223097131810 · 2022

Recent studies have focused heavily on tumor-oriented nanocarriers mediated by cell- penetrating peptides (CPPs). However, the loss of CPPs in normal tissues and enzymatic degradation in circulation frequently prevented …

Pradnya Zambare, Avinash Survase, Shivangi Kanase

pp. 106–112 · DOI: 10.5530/223097131692 · 2022

Objectives:We reported a non-toxic, low-cost and environmentally friendly green synthesis technique for the manufacture of copper nanoparticles (Cu NPs) utilizing Ocimum sanctum (O. sanctum) leaf extract to prevent hospi…

Ibrahim Baje Syed, Madhavi Nannapaneni

pp. 113–121 · DOI: 10.5530/223097131696 · 2022

Background: Axitinib was used to treat carcinoma of renal cells and Upadacitinib was used to treat rheumatoid arthritis and Zanubrutinib used as an anti cancer medication for mantle cell lymphoma. In the current applicat…

Mohammad Rashid Iqbal, Satish Kumar Sharma

pp. 122–128 · DOI: 10.5530/223097131721 · 2022

Aim: The present study was to investigate the effects of WSE improve cognitive, behavioral and mood disorders in animal models of bipolar disorder. Materials:Animals were divided into six groups each group contain 6 wist…

Bashir A Sheikh, Basharat A Bhat, Masood A Rizvi, Zahoor Ahmad, Abdullah Almilaibary, Mustfa Alkhanani, Manzoor A Mir

pp. 129–138 · DOI: 10.5530/223097131750

Background:DprE1, which is a flavoenzyme, is very important for cell wall biosynthesis in Mycobacterium tuberculosis (Mtb) and for the pathogenesis, virulence, lethality, and stress resistance of the host. Drug-resistant…

Vikash , Gupta, Mohan Lal Kori

pp. 139–148 · DOI: 10.5530/223097131485 · 2022

Background:Diabetes becomes a chronic disease when glucose constantly remains high and uncontrolled. As time goes off, it may gradually develop acute or chronic associated complications. Diabetic neuropathy is one of the…