Volume 12, Issue 4

Leena Rajathy Port Louis, Prithiviraj Nagarajan, Asokan Balakrishnan Ramajayam

pp. 400–402 · DOI: 10.5530/ijpi.2022.4.69 · 2022

Animal experiments are routinely carried out worldwide either in educational setups or in research setups. Animal research can be basic or applied, where in the applied research the test compound/drug is tested in animal…

Vaibhav SU, Vedamurthy Joshi, Prakash Goudanvar, Soumik Banerjee, Vinay Prasad S

pp. 403–407 · DOI: DOI: 10.5530/ijpi.2022.4.70 · 2022

The Office of combination products OCP, an agency to regulate the combination products under the US Food and Drug Administration (FDA) has released the final guidance on the combination products for its approval which is…

Gaurav Tiwari, Akanksha Chauhan, Pooja Sharma, Ruchi Tiwari

pp. 408–417 · DOI: 10.5530/ijpi.2022.4.71 · 2022

Capra hircus (Goats) are a vital part of the livestock industry because of their ability to adapt to harsh conditions, making them ideal for landless and marginal farmers. The Capra hircus is one of the most prominent op…

Kevizano Jacinta Zashumo, V Mathivanan, Hezinglila Grace, D Leelavathi

pp. 418–422 · DOI: 10.5530/ijpi.2022.4.72 · 2022

Background:Obesity is a major problem that many individuals suffer presently. Using in silico Tools and Servers, we propose to build a novel chemical drug and validate its oral toxicity effect. Our strategy entails first…

Anushya Sankar, Shanthi Periyasamy, Sownthariya Chandrabalan

pp. 423–429 · DOI: 10.5530/ijpi.2022.4.73 · 2022

Background: Morinda umbellata L., commonly called as ‘Manjanatti Kodi’ in Tamilnadu, India, is a rare traditional medicinal plant. The study was aimed to investigate the antioxidant potentiality, phytochemical profiling …

Rameshor Singh Atom, Shaukat Ali M Shaikh, Kishorjit Maharabam, Rakhi Khunjamayum, Dini Ahanthem, Warjeet Singh Laitonjam, Raghumani Singh Ningthoujam, Amit Kunwar

pp. 430–437 · DOI: 10.5530/ijpi.2022.4.74 · 2022

Bakground: Kaempferia parviflora (zingiberaceae family) rhizomes are used for various pharmacological applications. The present study is aimed for putative identification of phyto-constituents in the chloroform extract o…

Donthamsetty V Sowmya, Srirama Swarnalatha, Morusu Keerthana, Pothina Devi Guna Sireesha, Maruvajhala Vidyavathi

pp. 438–443 · DOI: 10.5530/ijpi.2022.4.75 · 2022

Background: Liver is one of the most important human organs and is a sensitive target for chemicals that modulate biotransformation. The present study aimed to develop a polyherbal formulation in the form of both capsule…

N Raghavendra Babu, R Subhakar Raju, Narender Malothu, Yenumula Padmavathi

pp. 444–448 · DOI: 10.5530/ijpi.2022.4.76 · 2022

Background: The largest infectious agent-related cause of death and the most common disease with a high contagiousness profile is tuberculosis. For the treatment of tuberculosis, various benzimidazole and quinazoline com…

Somesh Kumar Saxena, Om Prakash Agrawal, Ashish Pathak

pp. 449–454 · DOI: 10.5530/ijpi.2022.4.77 · 2022

Background:Chroman-4-one, also known as 2,3-dihydro-1-benzopyran- 4-one, is a heterocyclic compound with a benzene nucleus fused to a 2,3-dihydro-g-pyranone ring. The synthesis of chroman-4-one derivatives is a very appe…

Ram Lal Saini, Seema Parveen, Rajni Bais

pp. 455–461 · DOI: 10.5530/ijpi.2022.4.78 · 2022

Background:This research was focused on the development of a quick, simple, precise, and cost-effective voltammetric method for quantifying dosulepin. Materials and Methods:The antidepressant drug (dosulepin) was assesse…

PH Viramgama, CD Modi, DJ Patel, AB Chaudhary

pp. 462–469 · DOI: 10.5530/ijpi.2022.4.79 · 2022

Background: Alcohol induced dose dumping is a noteworthy question in designing of modified release dosage forms and it led the marketed products withdrawal by regulatory agencies. Diltiazem HCl is a highly watersoluble d…

Rajashri Namdev Kausdikar, Manish S Kondawr, Fahim J Sayyad

pp. 470–474 · DOI: 10.5530/ijpi.2022.4.80 · 2022

Background:Dry skin conditions’ primary and secondary infections can be treated by using mupirocin topically. By overcoming the disadvantages of ointments, creams, and lotions, the goal of the formulation of mupirocin em…

Sreejan Manna, Abdul Aziz, Sanchita Das, Manas Bhowmik

pp. 475–478 · DOI: 10.5530/ijpi.2022.4.81 · 2022

Background:Glibenclamide is a second-generation sulfonylurea extensively associated with the therapy of diabetes mellitus. A sustained release of the drug in the gastrointestinal tract may aid in maintaining therapeutic …

Harini Narayanam, Archana Rajagopalan, Subramani Parasuraman, Parayil Varghese Christapher, Suresh V Chinni

pp. 479–482 · DOI: 10.5530/ijpi.2022.4.82 · 2022

Background: Parkinson’s disease (PD) is one of the most common degenerative disorders of the ageing brain. Currently, there is no cure for PD and most of the available treatments only aim to reverse the dopamine deficien…

Afaf S Alwabli

pp. 483–488 · DOI: 10.5530/ijpi.2022.4.83 · 2022

Background:Dengue virus is transmitted by the mosquito species Aedes aegypti and causes dengue fever. The single positive-stranded RNA virus of the family Flaviviridae belongs to the genus Flavivirus. There is four dengu…

Pradeep Battula, Bhupalam Pradeep Kumar

pp. 489–492 · DOI: 10.5530/ijpi.2022.4.84 · 2022

Background:When two antibiotics are used at the simultaneously, they interact. The interaction could be either synergistic or antagonistic. However, an antagonistic combination may halt the action of another antibiotic, …