Volume 15, Issue 4

Vibha, Shiv Bahadur, Meenakshi Bajpai

pp. 1340–1347 · DOI: 10.5530/ijpi.20250272 · 2025

Introduction Wounds may be known as any damage or distortion to the normal structural and functional of skin, if left untreated it can be more dangerous, reaching in subcutaneous tissue and serious harm to other structur…

Anuj Kumar, Anurag Verma

pp. 1348–1359 · DOI: 10.5530/ijpi.20250312 · 2025

Background In situ forming dental cements offer a novel approach to treating periodontitis by enabling localized delivery of therapeutic agents directly to the periodontal cavity. Hydroxyapatite-based materials hold prom…

Bolleddu Ravi, Thangallapalli Srinivas, Kuntla Raj Kumar, Mannepalli Sudheera

pp. 1360–1364 · DOI: 10.5530/ijpi.20250007 · 2025

Aim/Background Micro-channels, characterized by their minuscule size ranging from 10 µm to 200 µm, find diverse applications across various fields such as biomedical, electronics, and chemical reactors, etc. Here, it was…

Swarna Lekha Suresh Gandhi, Anitha Rajasekaran, Harika Manniam Saravanabava, Munusami Angusami

pp. 1365–1369 · DOI: 10.5530/ijpi.20250008 · 2025

Background Melatonin (N-acetyl -5- methoxy-tryptamine) is a mammalian neuro hormone, with numerous biological functions found in animals, plants, microorganisms and one of the extensively used dietary supplements. Phytom…

Kezia Mangalampalli, Aravinda Sai Kolusu, Hrushik Kowtinya Ramineni, Harshitha Mudigonda, Surya Devarakonda, Pavan Kumar Samudrala

pp. 1370–1379 · DOI: 10.5530/ijpi.20250009 · 2025

Background Cholinergic neurons in the brain and hippocampus appear to be most affected in the early stages of Alzheimer's Disease (AD). Cognitive impairment has been induced in rodents for many years with the muscarinic …

Jamith Basha Abdul Wahid, Mohameed Aljuwayd, Muhannad Alruwaili, Wesam Nofal

pp. 1380–1387 · DOI: 10.5530/ijpi.20250304 · 2025

Background Nutritional modifications arise from an enhanced understanding of the importance of food and its impact on human well-being. Objectives This study investigates the fermentation-based preservation of edible mus…

Vinay Kumar Srivastava, Khushboo Rani

pp. 1388–1395 · DOI: 10.5530/ijpi.20250102 · 2025

Objectives Cysteine is a promising ligand for synthesizing complexes with Mn (II) and Cu (II) ions. The main objectives of the study were to synthesize, characterize and examine the Biochemical behavior of metal complexe…

Tejas Vyas, Ujashkumar Shah, Jayvadan Patel, Mrityunjay Tiwari

pp. 1396–1402 · DOI: 10.5530/ijpi.20250407 · 2025

Background Ascorbic acid and gallic acid are known for immune-boosting and antioxidant properties. Objectives To develop a straightforward, sensitive, validated, and economical reverse phase liquid chromatographic techni…

Vakkalagadda Siva Ganesh, Bharathi Doddla Raghunathanaidu

pp. 1403–1408 · DOI: 10.5530/ijpi.20250545 · 2025

Background 11β-hydroxylase plays a key role in adrenal steroid hormone production, making it crucial in the development of adrenal insufficiency. Recently, there has been increasing interest in targeting this enzyme to i…

Pratibha Yadav, Kamal Shah

pp. 1409–1416 · DOI: 10.5530/ijpi.20250577 · 2025

Objectives To investigate the mechanism of pyridopyrimidines derivatives against monopolar spindle1 anticancer target and also predicts the pharmacokinetics parameters involved absorption, distribution, metabolism, elimi…

Patibandla Sai Sandhya, Soma Mani Santhosh Nikhil, Phakkir Vineela Reddy, Rekala Niharika, Maram Chinnaeswaraiah

pp. 1417–1424 · DOI: 10.5530/ijpi.20250441 · 2025

Background Renal pathologies, encompassing Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI), represent considerable public health challenges, contributing to heightened morbidity and mortality rates on a global…

Mohomed Faizal Umair Ahamed, Gothai Sivapragasam, Nanthini Sridewi Appan

pp. 1065–1072 · DOI: 10.5530/ijpi.20250125 · 2025

This review offers an overview of the crucial role microglia play in neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases. It also delves into the therapeutic potential of natural produc…

Abdulhadi M Abdulwahed

pp. 1073–1085 · DOI: 10.5530/ijpi.20250384 · 2025

This review aims to discuss the progress made in targeted drug delivery of small molecules in breast cancer, as well as the methods that can be used to increase the accuracy of the treatment and reduce the overall toxici…

Gopinath Govindarajan, Ranganadhareddy Aluru

pp. 1086–1095 · DOI: 10.5530/ijpi.20250277 · 2025

In biopharmaceutical manufacturing chromatography technique has been the backbone of purification process. As bioprocessing has advanced, a growing trend has emerged toward gaining a thorough understanding of the fundame…

Rajendran Akash, Sathiyamoorthy Rajesh, Bhuvaragavan Devishree, Karthikeyan Aravind, Selvaraj Deepa, Kesavan Sathesh Kumar

pp. 1096–1107 · DOI: 10.5530/ijpi.20250319 · 2025

This review article provides a comprehensive examination of collagen-loaded dental applications, focusing on collagen dental plugs used for socket preservation and tissue regeneration following tooth extraction. It explo…

Ajay Charan, Lita Susan Thomas, Vaishali Bambal, Vanaja Kenchappa, Anju Jose

pp. 1108–1121 · DOI: 10.5530/ijpi.20250508 · 2025

Ventilator-Associated Pneumonia (VAP) is a prevalent and serious hospital-acquired infection occurring in critically ill patients who have been mechanically ventilated for over 48 hr. It is primarily caused by Gram-negat…

Mahavir M. Sharma, Harshkumar Brahmbhatt, Priyanka Shah, Ujjval P. Vaghela

pp. 1122–1129 · DOI: 10.5530/ijpi.20250488 · 2025

This review delineates the primary objectives of Quality by Design (QbD) and provides an in-depth exposition of its foundational concepts. The core components of QbD include: (1) the establishment of a comprehensive cont…

Venkateswara Raju Kalidindi, Gutturu Dheeraj Balaji, Uda Mahalakshmi, Sirilla Dinesh Babu, Badugu Priyanka, Tekumudi Vasantha Naga Lakshmi, Lakshmi Prasanthi Nori

pp. 1130–1143 · DOI: 10.5530/ijpi.20250005 · 2025

Decentralized Clinical Trials (DCT) utilize digital health technologies, remote monitoring, and telehealth, eliminating the need for traditional in-person visits to clinical sites. This model provides significant benefit…

Lakshmi Prasanthi Nori, Ketha Bhavani, Yamini Satya Sri, Gangomolu Pujitha, Kiran Manda, Sudarshan Rao Nagineni, Kalidindi Venkateswara Raju

pp. 1144–1152 · DOI: 10.5530/ijpi.20250006 · 2025

Materiovigilance refers to the system of safety monitoring and performance of medical devices after being placed on the market and involves collecting, analyzing, and responding to reports of malfunctions, adverse events…

Jiafeng Li, Tiefeng Jin, Meihua Zhang

pp. 1153–1159 · DOI: 10.5530/ijpi.20250329 · 2025

The "Four New" initiatives have emerged as a pivotal framework for advancing higher education in China. Among these, the promotion of New Medical Sciences not only meets the evolving demands of the contemporary era but a…