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International Journal of Pharmaceutical InvestigationNOW IN
Article

Synergistic effect of Carum copticum and Mentha piperita essential oils with ciprofloxacin, vancomycin, and gentamicin on Gram‑negative and Gram‑positive bacteria

Gholam-Reza Talei1, Mohsen Mohammadi1, Mahmoud Bahmani2, Mahmoud Rafieian Kopaei3★★ Corresponding author

  1. 1Department of Microbiology, Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khorramabad.
  2. 2Department of Microbiology, Leishmaniasis Research Center, Ilam University of Medical Sciences, Ilam.
  3. 3Department of Pharmacology, Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IRAN.

CORRESPONDENCE

Mahmoud Rafieian Kopaei

Department of Pharmacology, Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IRAN.

rafieian@yahoo.com

Volume 7, Issue 2 · pp. 82–87 · PUBLISHED · DOI: 10.4103/jphi.JPHI_12_17

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ABSTRACT

Background:Infectious diseases have always been an important health issue in human communities. In the recent years, much research has been conducted on antimicrobial effects of nature‑based compounds because of increased prevalence of antibiotic resistance. The present study was conducted to investigate synergistic effect of Carum copticum and Mentha piperita essential oils with ciprofloxacin, vancomycin, and gentamicin on Gram‑negative and Gram‑positive bacteria. Materials and Methods: In this experimental study, the synergistic effects of C. copticumand M. piperita essential oils with antibiotics onStaphylococcus aureus (ATCC 25923), Enterococcus faecalis (ATCC 29212), Escherichia coli (ATCC 8739), Pseudomonas aeruginosa (ATCC 9027), Staphylococcus epidermidis(ATCC 14990), andListeria monocytogenes(ATCC 7644) were studied according to broth microdilution and the MIC and fractional inhibitory concentration (FIC) of these two essential oils determined.Results: C. copticum essential oil at 30 μg/ml could inhibit S. aureus, and in combination with vancomycin, decreased MIC from 0.5 to 0.12 μg/ml. Moreover, the FIC was derived 0.24 μg/ml which represents a potent synergistic effect with vancomycin against S. aureus growth. C. copticumessential oil alone or combined with other antibiotics is effective in treating bacterial infections.Conclusions: In addition, C. copticumessential oil can strengthen the activities of certain antibiotics, which makes it possible to use this essential oil, especially in drug resistance or to lower dosage or toxicity of the drugs.

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    Talei, G., Mohammadi, M., Bahmani, M., & Kopaei, M. R. (). Synergistic effect of Carum copticum and Mentha piperita essential oils with ciprofloxacin, vancomycin, and gentamicin on Gram‑negative and Gram‑positive bacteria. International Journal of Pharmaceutical Investigation, 7(2), 82–87. https://doi.org/10.4103/jphi.JPHI_12_17