Comparison of effectiveness of Calendula officinalis extract gel with lycopene gel for treatment of tobacco‑induced homogeneous leukoplakia: A randomized clinical trial

ABSTRACT

Aim:The aim of the study is to assess the efficacy of Calendula officinalis gel as cost‑effective treatment modality in comparison to lycopene gel in the treatment of leukoplakia. Materials and Methods:The study comprised of sixty patients of clinically diagnosed and histopathologically confirmed cases of homogeneous leukoplakia which were divided into Group I and Group II with thirty patients each. Group I patients were dispensedC. officinalisextract gel whereas Group II patients were given lycopene gel. The therapy was instituted for 1 month to assess the change in the size of the lesion at the baseline and posttreatment.Results: The results revealed a statistically significant difference in both Group I and Group II when the pre‑ and post‑treatment results were compared in the same group. The mean difference in the reduction in size before and after treatment for Group I was 2.0% ±1.0 cm while for the Group II, it was 1.57% ±0.87 cm. The intergroup comparison for the evaluation of reduction in the size of the lesion did not reveal statistically significant results. Conclusion: C. officinalis extract gel can be effectively used as an alternative to conventional treatment modality.

KEYWORDS

• Calendula officinalis
• leukoplakia
• lycopene

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• DOI10.4103/jphi.JPHI_19_17Copy

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