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International Journal of Pharmaceutical InvestigationNOW IN
Article

Evaluation of Nootropic activity of Ethanolic and Aqueous Root Extracts of Adhatoda vasica nees in Rodents

Kola Venu1, Prasenjit Mondal2★, Rajesh BRC3, Arjun Goje4, Gummadevelly Sandeep5, Manish Kumar Thimmaraju6, Shaik Chanbasha3, Bhookya Padmaja2★ Corresponding author

  1. 1Vaageswari College of Pharmacy, Karimnagar, Telangana, INDIA.
  2. 2Vaageswari Institute of Pharmaceutical Sciences, Karimnagar, Telangana, INDIA.
  3. 3V.L. College of Pharmacy, Raichur, Karnataka, INDIA.
  4. 4Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad, Telangana, INDIA.
  5. 5Pathfinder Institute of Pharmacy Education and Research, Warangal, Telangana, INDIA.
  6. 6Balaji Institute of Pharmaceutical Science, Narshampet, Telangana, INDIA.

CORRESPONDENCE

Prasenjit Mondal

Vaageswari Institute of Pharmaceutical Sciences, Karimnagar, Telangana, INDIA.

prasenjitmyname@gmail.com

Volume 9, Issue 4 · pp. 180–186 · PUBLISHED · DOI: 10.5330/ijpi.2019.4.34

View on IJPI original site ↗

ABSTRACT

Objectives: The Present study was planned to evaluate the nootropic activ- ity of ehanolic extract of Adhatoda vasica nees (EERAV) and aqueous ex- tract of A. vasica (AQERAV) in experimentally induced amnesic models in mice and rats. Methods: AERAV and AQERAV were prepared successively with roots of A. vasica using soxhlet apparatus. LD50 studies for these two extracts were carried out in albino mice up to the dose level of 2000 mg/kg as per guidelines No. 425 of CPCSEA. EERAV and AQERAV were studied for their nootropic effect evaluated in five different experimental models like Active (Rats) and Passive avoidance, Diazepam, Scopolamine, Sodium nitrite induced amnesia and Sodium nitrite induced hypoxia models all in mice. The parameters studied in nootropic activity are Step Down Latency (SDL), Step Down Error (SDE), Time spent in Shock Zone (TSZ), Number of shocks, Transfer Latency (TL) and Time for cessation of respiration. Results: No mortality observed even at the highest dose tested (2000 mg/ kg) and did not produce any significant effect on locomotor activity in mice. Experimental studies have shown that EERAV and AQERAV have exhibited a dose dependent nootropic activity. A Significant nootropic activity was recorded with both the extracts in Active and Passive avoidance, Scopol- amine, Diazepam and Sodium nitrite induced amnesia models. AQERAV exhibited a significant nootropic effect with medium and high doses only in Active and Passive avoidance models, scopolamine and Diazepam induced amnesia models. Conclusion:The present study suggests that both ex- tracts possessed a significant nootropic activity in mice and rats.

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    Venu, K., Mondal, P., BRC, R., Goje, A., Sandeep, G., Thimmaraju, M. K., Chanbasha, S., & Padmaja, B. (). Evaluation of Nootropic activity of Ethanolic and Aqueous Root Extracts of Adhatoda vasica nees in Rodents. International Journal of Pharmaceutical Investigation, 9(4), 180–186. https://doi.org/10.5330/ijpi.2019.4.34