Volume 17, Issue 4

Vinay Kumar, Sadhana Misar Wajpeyi, Pankaj Yadav, Bhishmani Tarare

pp. 477–487 · DOI: 10.1177/0976500X251398611 · 2026

Background: Immunotherapy has wholly changed how cancer is treated by using the body’s immune system to eliminate cancer cells. Cancer vaccines, chimeric antigen receptor T-cell (CAR-T) treatments, and immune checkpoint …

Nitika Senger, Sourabh Deshmukh

pp. 488–498 · DOI: 10.1177/0976500X251398610 · 2026

Background: Autoimmune and inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and psoriasis, are typified by immune dysregulation resulting in chronic inflammation and pr…

Paneer Selvam Pandian, Selvaraj Vinoth Kumar, Anupam Biswas, Usha Kumari, Subramani Parasuraman

pp. 499–506 · DOI: 10.1177/0976500X261463370 · 2026

Metabolic disorders, including diabetes mellitus and obesity, continue to pose a major public health challenge. Diabetes is a disorder of glucose metabolism that can be associated with vestibular dysfunction. Traditional…

Kapil Yadav, Rohit Malik, Nidhi Gehlawat, Namita Solanki, Syam Mohan, Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Abdullah Farasani, Jobran M. Moshi, Ahmad Assiri, Saeed Alshahrani, Khaled A. Sahli, Hussam M. Shubaily, Marwa Qadri, Amani Khardali, Waseem Hassan

pp. 507–517 · DOI: 10.1177/0976500X261438924 · 2026

Polycystic ovary syndrome (PCOS) is a chronic endocrine disorder affecting women of reproductive age, with a prevalence of about 10%. Hyperandrogenism, anovulation, polycystic ovarian morphology, and related hormonal and…

Mohammad Firoz Alam, Ali Mohammed Ali Hazazi, Mohamed Ahmed Al-Kasim, Abdulmajeed M. Jali, Ali Hanbashi, Saeed Alshahrani, Ayed A. Alshamrani, Wedad Mawkili, Maqbool Essa Oraiby, Sami Ibrahim, Ahmad Ali Daghriri, Syam Mohan, Yahya Mashour

pp. 518–529 · DOI: 10.1177/0976500X261417397 · 2026

Background: Doxorubicin (DOX), an anthracycline-based chemotherapeutic agent, has been widely used as a first-line treatment for several cancers, including hematological and solid tumors, but its clinical utility is limi…

Gobinath Ramachawolran, Kasi Marimuthu, Sreeramanan Subramaniam, Suresh V. Chinni

pp. 530–543 · DOI: 10.1177/0976500X261420581 · 2026

Background: Buprofezin, a thiadiazine insecticide globally recognized as a molting inhibitor, is widely used for controlling whitefly and other insect pests. Objectives: This study investigated the impacts of sub-lethal …

Snehalakshmi Kavacheri Subramaniam, Umamaheswari Anbarasu, Bhuvaneswari Krishnamurthy, Manashaa Gnanaprakasam Poonguzhali

pp. 544–552 · DOI: 10.1177/0976500X261417415 · 2026

Background: Osteoarthritis (OA) is the most common form of arthritis affecting the elderly and obese population, and requires long-term medical management. Inflammatory pathways, possibly initiated by tissue damage and s…

Sohith Reddy Korlagunta, Iniyan Muthamil Selvan, Sugapriya Dhanasekaran

pp. 553–561 · DOI: 10.1177/0976500X261417108 · 2026

Background/Objectives: Alzheimer’s disease (AD) is a long-term neurodegenerative condition that leads to the gradual deterioration of nerve cells. The goal of this study is to use computational drug discovery (CDD) techn…

Seham M. Alsuhaymi, Khalid M. Almalki, Sarah I. Alghamdi, Shahad R. Kelantan, Rana M. Alnefaie, Eyad A. Alandijani, Atheer A. Jamal, Mohammed Shaikhomer, Asim M. Alshanberi, Reem B. Busaeed, Safaa M. Alsanosi, Yosra Z. Alhindi

pp. 562–570 · DOI: 10.1177/0976500X261417396 · 2026

Background: Chronic diseases present a significant health risk, and global medication adherence for these conditions remains insufficient. Understanding the factors that affect adherence is essential. Objectives: This st…

Zihan Liu, Ganmi Wang, Ning Chen, Jiarong Wu, Yueyuan You, Fei Qin, Huan Zhou

pp. 571–578 · DOI: 10.1177/0976500X261420055 · 2026

Background: MRSA and PRSP resistance has surged over 30 years, threatening clinical outcomes; China-developed cefathiamidine sodium, with enhanced pharmacokinetics, offers potent activity against these Gram-positive path…

Prashant Kumar Singh, Shruti Singh, Veena Kumari Singh, Rajesh Kumar Meena

pp. 579–587 · DOI: 10.1177/0976500X261461084 · 2026

Competency-based medical education (CBME) marks a paradigm shift in medical training by prioritizing outcomes over timebased progression and focusing on clearly defined competencies aligned with societal needs. Faculty s…

Suvajit Podder, Savan Kumar Nagesh, Shweta Sinha, Deepali Shetty, Anula Dsouza

pp. 588–595 · DOI: 10.1177/0976500X261462416 · 2026

Background: Regional anaesthesia is widely preferred for upper limb surgeries, particularly those performed below the elbow; however, the limited duration of action of local anaesthetics remains a clinical challenge. The…

Priya Jaswal, Rishabh Chaudhary, Jhilli Basu, Sowvik Bag, Sumeet Gupta, Seema Bansal

pp. 596–608 · DOI: 10.1177/0976500X261462646 · 2026

Background: Heat stress (HS) is the body’s inability to manage internal heat efficiently. It impairs endothelial function, causes oxidative stress, and disrupts nitric oxide (NO) signaling, highlighting the downstream ef…

Mujtaba Mahmud, Matthew T. Stier, Jonathan D. Casey, Rebecca E. Bruccoleri, Joanna L. Stollings

pp. 609–616 · DOI: 10.1177/0976500X251409926 · 2026

A case of colchicine overdose of 27 mg, or 0.27 mg/kg (weight 99.8 kg), is reported to assess the potential symptoms seen with this type of toxicity and analyze a prospective treatment for successful outcomes. A 74-year-…

Paul Mathi Vathana Karunagaran, Edlin Domini Thakkekara

pp. 617–623 · DOI: 10.1177/0976500X261417406 · 2026

Background: Patients with acute promyelocytic leukemia (APML) undergoing induction therapy are severely immunocompromised and prone to opportunistic infections. Tuberculosis (TB), though less commonly considered, can com…

Hunar Jaiya, Nitya K., Sandhya Sundar, Ramya Ramadoss, Suganya Panneer Selvam

pp. 624–633 · DOI: 10.1177/0976500X261421671 · 2026

Background: Down syndrome (DS), caused by trisomy 21, is characterized by chronic oxidative stress resulting from overexpression of the superoxide dismutase 1 (SOD1) gene without a proportional increase in downstream ant…