Volume 3, Issue 1

Gitanjali B.

pp. 1–3 · DOI: 10.4103/0976-500X.92490 · 2012

Scientific writing calls scientists to say the truth, the whole truth and nothing but the truth. But in reality, try writing that and the chances are that your work will not get published;—at least not until it is said t…

Mostafa Yakoot

pp. 4–6 · DOI: 10.4103/0976-500X.92491 · 2012

Based primarily on the Final Report of the Hemorrhagic Stroke Project (HSP) released on May 2000,[3,4] the Food and Drug Administration (FDA) had concluded that there is an association between PPA and hemorrhagic stroke.…

Dilip Gude

pp. 7–8 · DOI: 10.4103/0976-500X.92492 · 2012

We have a plethora of new antihypertensives coming up with diverse mechanisms of action but if that would drastically change and better the management of hypertension remains to be seen. A review of the newer classes of …

(Kir6.1s) (Kir6.1s), regulatory sulphonylurea subunits (SUR).[3] IPT shows high selectivity for cardiac KATP (SUR2A/Kir6.2), vascular KATP (SUR2B/Kir6.1 or SUR6B/Kir6.2). Because

pp. 12–14 · DOI: 10.4103/0976-500X.92495 · 2012

Hypertension is a multifactorial disorder, and effective blood pressure control is not achieved in most individuals. According to the most recent report of the American Heart Association, for 2010, the estimated direct a…

Yatan Pal Singh Balhara, Raka Jain

pp. 15–19 · DOI: 10.4103/0976-500X.92496 · 2012

Objectives: To understand the pattern of use of opioid-substitution therapy (OST) and opioid abuse among patients on buprenorphine maintenance using urinalysis. Materials and Methods: The study was conducted at a tertiar…

antagonist to angiotensin II type1 receptor: Novel in

pp. 20–25 · DOI: 10.4103/0976-500X.92497 · 2012

Objectives: To study the ability of the secondary metabolites of Cynodon dactylon to serve as an antagonist to angiotensin II type 1 receptor (AT1); activation of this receptor plays a vital role in diabetic retinopathy …

Christo Paul Preethy, Ramamoorthy Padmapriya, Vaiyapuri Subbarayan Periasamy, Anvarbatcha Riyasdeen, Suresh Srinag, Hanumanthappa Krishnamurthy, Ali Abdullah Alshatwi, Mohammad Abdulkader Akbarsha

pp. 26–34 · DOI: 10.4103/0976-500X.92500 · 2012

Objectives: To find the efficacy of serial extracts of Anisomeles malabarica in inhibiting proliferation of and inducing apoptosis in human cervical cancer cells, SiHa and ME 180, that are HPV 16-positive. Materials and …

B. N. Karelia, J. G. Buch

pp. 35–38 · DOI: 10.4103/0976-500X.92504 · 2012

Objectives: To analyze the hematinic formulations available in Indian market for their varieties of dosage forms, iron salts used, content of elemental iron, frequency of administration, additional nutrients, and cost. M…

Marcelo Perim Baldo, Sérgio Lamêgo Rodrigues, José Geraldo Mill

pp. 39–40 · DOI: 10.4103/0976-500X.92508 · 2012

Objectives: To evaluate the acute effects of colony-stimulating factor (G-CSF) on ventricular arrhythmias after coronary occlusion in rats. Materials and Methods: Male Wistar rats (10 weeks) received G-CSF (100 μg.kg-1) …

Surender Singh, Vinod Nair, Yogendra K. Gupta

pp. 43–47 · DOI: 10.4103/0976-500X.92512 · 2012

Objectives: To study the effect of acute and repeated dose administration of lyophilized aqueous extract of the dried fruits of Tribulus terrestris (LAET) on sexual function in sexually sluggish male albino rats. Materia…

Chanda Kulkarni, Leena A., Lohit K., Devesh Mishra, Saji M. J.

pp. 48–54 · DOI: 10.4103/0976-500X.92515 · 2012

Objectives: To compare the safety and efficacy of glucosamine HCl- sustained release (GLU-SR) with that of Glucosamine HCl- immediate release (GLU-IR) in patients with knee osteoarthritis (OA). Materials and Methods: Thi…

Jaykaran, Preeti Yadav, N. D. Kantharia, Deepak Saxena

pp. 55–56 · DOI: 10.4103/0976-500X.92517 · 2012

Pharmaceutical industries promote their drugs with the intention to influence the prescription decision of health care provider / physicians and adopt various methods like distribution drug promotional materials to the h…

Pramod B. Akat, Vitthal B. Karande, Mangala B. Murthy, Shreyas R. Burute

pp. 56–58 · DOI: 10.4103/0976-500X.92519 · 2012

The rational prescribing of drugs is an essential skill of medical doctors. Clinical pharmacology plays an important role in the development of these skills by teaching clinical pharmacology and therapeutics to undergrad…

Dinesh Dhingra, Parul Joshi

pp. 60–61 · DOI: 10.4103/0976-500X.92520 · 2012

Depression is one of the major mental disorders affecting hundreds of millions of people all over the world. There is a constant need to identify newer antidepressants from plants. Benincasa hispida (Cucurbitaceae) fruit…

T. S. Nagaraja, Riaz Mohamood, V. Krishna, B. S. Thippeswamy, V. P. Veerapur

pp. 62–63 · DOI: 10.4103/0976-500X.92521 · 2012

Epilepsy is a common neurological disorder characterized by paroxysmal dysrhythmia, seizure, with or without body convulsions and sensory or psychiatric phenomena. There are many mechanisms by which seizures can develop …

Parveen Kumar, Shailesh Baraiya, S. N. Gaidhani, M. D. Gupta, Manish M. Wanjari

pp. 64–65 · DOI: 10.4103/0976-500X.92522 · 2012

Diabetes mellitus, a chronic metabolic disorder of insulin deficiency or ineffectiveness, constitutes a global public health burden and predictions estimate that India, China, and United States will have the largest numb…

S. Ganesan, S. Parasuraman, S. Uma Maheswaran, N. Gnanasekar

pp. 66–67 · DOI: 10.4103/0976-500X.92516 · 2012

The discovery of drugs from medicinal plants provides new and important leads against various pharmacological targets including chronic diseases such as Alzheimer’s disease, malaria, and pain.[1] Hemidesmus indicus (Tami…

K. A. Sudharshana Murthy, H. S. Kiran, Vijay Cheluvaraj, Abhijit Bhograj

pp. 68–70 · DOI: 10.4103/0976-500X.92513 · 2012

Bowel ischemia is a rare and potential life-threatening disorder. The reason for its rarity is the difficulty in its diagnosis. Vague and nonspecific clinical findings and limitations of diagnostic and treatment options …

Mahendra K. Patel, Tejas K. Patel, C. B. Tripathi

pp. 71–73 · DOI: 10.4103/0976-500X.92514 · 2012

A 5-month-old male patient developed recurrent seizures and acute encephalopathy possibly due to first dose of diphtheria, pertussis (whooping cough), and tetanus (DPT) vaccine used for routine immunization. Postreaction…

Dick B. S. Brashier, Sushil Sharma

pp. 74–75 · DOI: 10.4103/0976-500X.92501 · 2012

After the launch of National Pharmacovigilance Programme in 2004[1], the Government of India came out with a revised programme called “Pharmacovigilance Programme of India (PvPI)” in 2010,[2] to streamline the drug safet…