Volume 8, Issue 3

Subham Das, Prasanta Padhan

pp. 81–86 · DOI: 10.4103/jpp.JPP_194_16 · 2017

Rheumatoid arthritis (RA) is an autoimmune systemic disease characterized by long‑standing inflammation and significant joint destruction. Despite significant research and success toward the treatment modalities, complet…

Mohankrishna Ghanta, Elango Panchanathan, Bhaskar V. K. S. Lakkakula, Anbumani Narayanaswamy

pp. 87–91 · DOI: 10.4103/jpp.JPP_45_17 · 2017

Soluble guanylate cyclase (sGC) is an important transducing enzyme of cyclic guanosine monophosphate (cGMP) signaling pathway in striatum which has been considered as a potential target for the treatment of Parkinson’s d…

Nitishkumar D. Tank, Bharti N. Karelia, Bhavisha N. Vegada

pp. 92–105 · DOI: 10.4103/jpp.JPP_155_16 · 2017

Objective: To analyze available evidence on the safety of different biological response modifiers which are used for a treatment of rheumatoid arthritis (RA). Materials and Methods: We searched systematically for randomi…

Mrunalini Kalikar, Kundan S. Nivangune, Ganesh N. Dakhale, Chaitali S. Bajait, Smita D. Sontakke, Vijay M. Motghare, Ritu Budania

pp. 106–111 · DOI: 10.4103/jpp.JPP_39_17 · 2017

Objectives: To compare the efficacy and tolerability of losartan, telmisartan, and olmesartan as antihypertensive agents and evaluate and compare their effects on lipid profile and blood glucose. Materials and Methods: T…

Aloysius James, Malini Muraleedharan Nair, Dhanya Susan Abraham, Joel Sunny Kovoor, Wesley M. Jose, Remya Reghu

pp. 112–5 · DOI: 10.4103/jpp.JPP_54_17 · 2017

Objectives: To evaluate the efficacy and safety of lorazepam in reducing psychological distress and chemotherapy‑induced nausea and vomiting. Methodology: It was a prospective interventional study with seventy patients f…

Kinjal Prajapati, Mira Desai, Samidh Shah, Sumesh Choudhary, Rohina Aggarwal, Vineet Mishra

pp. 116–121 · DOI: 10.4103/jpp.JPP_43_17 · 2017

Objective: To compare different treatment regimens on pregnancy rate and outcome in patients with anovulatory infertility. Patients and Methods: A prospective observational study was conducted on patients with infertilit…

Najam Ali Khan, M. Abid, Aftab Ahmad, Mohammed F. Abuzinadah, Mohammed Basheikh, Kamal Kishore

pp. 122–127 · DOI: 10.4103/jpp.JPP_47_17 · 2017

Objectives: To investigate the effect of coenzyme Q10 (CoQ10) on apoptotic myocardial cell death in rat model of heart ischemia and reperfusion I/R injury. Materials and Methods: Eighteen rats (200–250 g) were divided in…

Desiderio Passali, Luisa Maria Bellussi, Codrut Sarafoleanu, Michele Loglisci, Claudiu Manea, Cristina Iosif, Francesco Maria Passali

pp. 128–9 · DOI: 10.4103/jpp.JPP_169_16 · 2017

The objective of our research was to find the concentration of bromelain in rhinosinusal mucosa of patients with chronic rhinosinusitis (Group A) and of individuals without nasal or paranasal diseases (Group B). Forty pa…

Yi Hong Zhang, Christopher E. Dempsey, Jules C. Hancox

pp. 130–131 · DOI: 10.4103/jpp.JPP_69_17 · 2017

The human Ether-à-go-go-Related Gene (hERG) encodes potassium channels mediating the rapid delayed-rectifier K+ current, IKr, which is crucial for normal repolarization of the ventricles of the heart. hERG is established…

Kayla R. Stover, John D. Cleary

pp. 132–133 · DOI: 10.4103/jpp.JPP_37_17 · 2017

Pharmacotherapy in patients with systemic fungal infections continues to challenge the heartiest clinicians. The inability of the antimycotic to discriminate the infected eukaryotic host from the pathogen often leads to …

Vijay Thawani, Abin Mani, Neeraj Upmanyu

pp. 134–6 · DOI: 10.4103/jpp.JPP_38_17 · 2017

The Jan Aushadhi Scheme (JAS) initiated by the Government of India is a powerful intervention against the unjustifiable pricing of medicines by private pharmaceutical industry, to make the generic medicines available at …

Jordan L. Kelley, Matthew Strum, Daniel M. Riche, Andrew M. Chandler

pp. 137–9 · DOI: 10.4103/jpp.JPP_20_17 · 2017

Sodium glucose transporter 2 inhibitors (SGLT2i) inhibit the reabsorption of glucose in the renal tubules reducing glycemia and increasing glucosuria. The increased glucosuria causes a shift in normal flora and colonizat…

Rachel Amanda Lowe, Katie Elizabeth Barber, Jamie Leigh Wagner, Allison Miriam Bell-Harlan, Kayla Renay Stover

pp. 140–4 · DOI: 10.4103/jpp.JPP_5_17 · 2017

Methicillin-susceptible Staphylococcus aureus (MSSA) causes 45% of S. aureus bloodstream infections (BSI) and is the most important cause of BSI-associated death. The standard of care therapy is an anti-staphylococcal pe…

Vinayaka Anuhya, Sushil Kiran Kunder, Sharath Madhyastha, Veena Nayak, Raviraja V. Acharya, Kusugodlu Ramamoorthi, Avinash Arivazhahan, Rahul Sai Gangula

pp. 145–147 · DOI: 10.4103/jpp.JPP_64_17 · 2017

Cephalosporins are a commonly used class of antibiotics in various types of infections. Cefepime, a fourth-generation cephalosporin, has been reported to cause neurotoxicity, which can present itself as varied manifestat…

Phulen Sarma, Gaurav Muktesh, Narender Dhaka, Rakesh Ruhela, Abhishek Mishra, Rahul Singh, Saroj K. Sinha, Bikash Medhi, Rakesh Kochhar

pp. 148–150 · DOI: 10.4103/jpp.JPP_42_17 · 2017

Terlipressin is used commonly in the management of hepatorenal syndrome and acute variceal bleeding. Like its parent compound vasopressin, it is also notorious for its ischemic complications. Terlipressin-induced ischemi…

Syed Ziaur Rahman

pp. 151–2 · DOI: 10.4103/jpp.JPP_105_17 · 2017

pp. 153–153 · DOI: 10.4103/0976-500X.215702 · 2017