Derivative Spectrophotometry Method for Simultaneous Estimation of Rupatadine and Montelukast in their Combined Dosage Form
1★, 2, 1, 1, 1★ Corresponding author
- 1Department of Pharmaceutical Chemistry, M.P. Patel College of Pharmacy, Jeevanshilp Campus, Kapadwanj, Dist-Kheda-387620, Gujarat, INDIA.
- 2Department of Pharmaceutical Chemistry, A.R. College of Pharmacy, Vallabh Vidyanagar, Gujarat, INDIA.
CORRESPONDENCE
Patel PG
Department of Pharmaceutical Chemistry, M.P. Patel College of Pharmacy, Jeevanshilp Campus, Kapadwanj, Dist-Kheda-387620, Gujarat, INDIA.
Volume 1, Issue 4 · pp. 351–358 · · DOI: 10.4103/0975-1483.59327
ABSTRACT
This study describes the development and validation for the simultaneous estimation of rupatadine and montelukast by the Þ rst-order derivative UV spectroscopy method. The quantiÞ cation was achieved by the Þ rstorder derivative spectroscopy method at 273.46 nm and 297.27 nm over the concentration range of 5-25 µg/ ml for estimation of rupatadine and montelukast in a combined tablet formulation. Procedure does not require prior separation of components from the sample. Rupatadine and montelukast were determined at 15 µg/ml with a mean recovery of 99.59 + 0.225 and 99.21 + 0.76, respectively. Calibration curves were linear with a correlation coefÞ cient of 0.9994 and 0.9992 for rupatadine and montelukast, respectively. The relative standard deviation was found to be <2.0%. The present result shows that the proposed method can be successfully used for simultaneous determination of the drug content in marketed formulations.
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PG, P., VM, V., SG, R., NB, R., & VH, B. (). Derivative Spectrophotometry Method for Simultaneous Estimation of Rupatadine and Montelukast in their Combined Dosage Form. Journal of Young Pharmacists, 1(4), 351–358. https://doi.org/10.4103/0975-1483.59327