Volume 1, Issue 4

Nandini D, Chauhan NS, Chandra A, Pathak K

pp. 285–289 · DOI: 10.4103/0975-1483.59314

Oxytetracycline HCl is an antibacterial drug used in the treatment of acne vulgaris and dermatitis. Its oral bioavailability is intermediate i.e., 60% and it is rapidly excreted through renal route. This drug has many si…

Mahajan R, Parvez A, Gupta K

pp. 290–294 · DOI: 10.4103/0975-1483.59315

Objectives: Human microdosing studies or phase 0 studies have been proposed to supplement pharmacokinetic (PK) studies in animals. In phase 0 studies, extremely low, nonpharmacologically active doses of a drug are given …

Bandela JJ, Anupama CH

pp. 295–300 · DOI: 10.4103/0975-1483.59316

The aim of this study is to enhance the dissolution rate of raloxifene hydrochloride and to prepare tablets by PEGylation. The high-molecular-weight polyethylene glycols, PEG 15 000 and PEG 35 000, were used for PEGylati…

Dhanaraju MD, Sundar VD, NandhaKumar S, Bhaskar K

pp. 301–304 · DOI: 10.4103/0975-1483.59317

Sustained-release polymeric beads containing diclofenac sodium were fabricated with hydrophilic polymers, sodium carboxymethyl cellulose (Na CMC), and sodium alginate (Na alginate). Particulate beads of Na CMC and Na alg…

Akbari BV, Dholakiya RB, Shiyani BG, Lodhiya DJ, Shastry CS

pp. 305–311 · DOI: 10.4103/0975-1483.59318

Gastro retentive drug delivery systems are the systems which are retained in the stomach for a longer period of time and thereby improve the bioavailability of drugs. Different approaches for gastro retentive dosage form…

Awasthi PK, Dixit SC

pp. 312–316 · DOI: 10.4103/0975-1483.59319

Hydro distillation of rhizomes and leaves of Curcuma longa resulted in the isolation of 0.36% and 0.53% of oils (w/v) respectively on a fresh weight basis. GC and GC-MS analysis resulted in the identiÞ cation of 73 const…

Ahmed F, Chandra JNNS, Timmaiah NV

pp. 317–321 · DOI: 10.4103/0975-1483.59320

Herbal medicines have been used since prehistoric times by different cultures worldwide for treatment of diabetes. In the present investigation, the effect of untreated and heat-treated aqueous extracts from Eugenia jamb…

Barwal SB, Nirmal Sunil A, Dhasade VV, Patil MJ, Pal SC, Mandal Subhash C

pp. 322–325 · DOI: 10.4103/0975-1483.59321

Punica granatum Linn. (Punicaceae) ß ower buds are used in the treatment of asthma traditionally, so the present work was undertaken to prove it scientiÞ cally using suitable animal models. Antihistaminic principles are …

Chandrashekar KS, Prasanna KS

pp. 326–329 · DOI: 10.4103/0975-1483.59322

Leucas lavandulaefolia Willd. is mainly used in Indian folk medicine for the treatment of diabetes mellitus. The oral administration of 0.15, 0.20 and 0.25 g/kg of chloroform extract of the Leucas lavandulaefolia ß owers…

Sikarwar MS, Patil MB, Kokate CK, Sharma S, Bhat V

pp. 330–335 · DOI: 10.4103/0975-1483.59323

This research aims to investigate the antidiabetic activity of Nerium indicum (Family: Apocynaceae) leaf extract in alloxan induced diabetic albino rats. A comparison was made between the action of Nerium indicum extract…

Shah PA, Parmar MY, Thakkar VT, Gandhi TR

pp. 336–340 · DOI: 10.4103/0975-1483.59324

The objective of the present study has been to evaluate the hepatoprotective activity of methanolic extract of Hordeum vulgare Linn. (MEHV) seeds against acetaminophen-induced liver damage in rats. Acetaminopheninduced l…

Piplani P, Rani A, Sandhir R, Kulkarni SK

pp. 341–350 · DOI: 10.4103/0975-1483.59325

A deÞ cit of cholinergic neurotransmission is considered to be one of the major causes of disturbance in learning and memory. Among the various therapeutic approaches investigated to enhance cholinergic transmission, ace…

Gnanarajan G, Gupta AK, Juyal V, Kumar P, Yadav PK, Kailash P

pp. 351–353 · DOI: 10.4103/0975-1483.59326

A simple new spectrophotometric method has been developed for estimation of Tenofovir disoproxil fumarate in bulk and tablet dosage form. Tenofovir disoproxil fumarate is estimated to be 261 nm in triple distilled water.…

Patel PG, Vaghela VM, Rathi SG, Rajgor NB, Bhaskar VH

pp. 351–358 · DOI: 10.4103/0975-1483.59327

This study describes the development and validation for the simultaneous estimation of rupatadine and montelukast by the Þ rst-order derivative UV spectroscopy method. The quantiÞ cation was achieved by the Þ rstorder de…

Hamrapurkar P, Phale M, Shah N

pp. 359–363 · DOI: 10.4103/0975-1483.59328

A simple, accurate, and precise HPTLC method has been developed and validated for the estimation of efavirenz from bulk drug and capsule formulations. The separation was achieved on TLC plates using an appropriate solven…

Chittora NC, Shrivastava A, Jain A

pp. 364–370 · DOI: 10.4103/0975-1483.59329

A simple, accurate, precise, economic, and speciÞ c stability indicating the RP-HPLC method has been developed for the estimation of Miglitol in tablet dosage form and spiked rabbit plasma. Chromatographic separation was…

Maliwal D, Jain P, Jain A, Patidar V

pp. 371–374 · DOI: 10.4103/0975-1483.59330

The rapid, simple, and accurate chromatographic (high-performance liquid chromatography) and spectrophotometric method for the determination of progesterone in capsule was elaborated. Methanol was found to be a suitable …

Ali N, Rehman S, Imran M, Hussian I, Shehbaz N, Jamshed H, Hayat A, Khan S, Anwar MJ

pp. 375–378 · DOI: 10.4103/0975-1483.59331

More than 850 patients’ medication history forms were evaluated, retrospectively, for possible irrationalities in the prescribing pattern of antibiotics for management of hospitalized diabetic foot cases. Primary anti-di…

Pol S, Janodia MD, Jagadeesh PC, Bhat KM, Udupa N

pp. 379–384 · DOI: 10.4103/0975-1483.59332

Business method patent grants to its holder exclusive rights to a particular way of doing business. Business method patents are a relatively new species of patent and there have been several reviews investigating the app…