jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Journal of Young PharmacistsNOW IN
Article

Quantitative Estimation of Efavirenz by High Performance Thin Layer Chromatography

Hamrapurkar P1★, Phale M1, Shah N1★ Corresponding author

  1. 1Department of Pharmaceutical Analysis, Prin. K. M. Kundnani College of Pharmacy, Jote Joy Building, Rambhau Salgaonkar Marg, Cuffe Parade, Colaba, Mumbai, INDIA.

CORRESPONDENCE

Hamrapurkar P

Department of Pharmaceutical Analysis, Prin. K. M. Kundnani College of Pharmacy, Jote Joy Building, Rambhau Salgaonkar Marg, Cuffe Parade, Colaba, Mumbai, INDIA.

phamrapurkar@gmail.com

Volume 1, Issue 4 · pp. 359–363 · PUBLISHED · DOI: 10.4103/0975-1483.59328

View on JYP original site ↗

ABSTRACT

A simple, accurate, and precise HPTLC method has been developed and validated for the estimation of efavirenz from bulk drug and capsule formulations. The separation was achieved on TLC plates using an appropriate solvent system. The spots so developed were densometrically scanned at 247 nm. The linearity of the method was found to be within the concentration range of 1-40 µg/ml. The validation parameters, tested in accordance with the requirements of ICH guidelines, prove the suitability of this method. The method was successfully applied for determination of drug in capsules, wherein no interference from capsule excipients was observed, indicating the speciÞ city of the developed method. Thus, the proposed method can be used successfully for routine analysis of efavirenz from capsule and bulk formulations.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    P, H., M, P., & N, S. (). Quantitative Estimation of Efavirenz by High Performance Thin Layer Chromatography. Journal of Young Pharmacists, 1(4), 359–363. https://doi.org/10.4103/0975-1483.59328