Impact of Selective Polymer on Optimization of Sustained Release Matrix Pellets of Sitagliptin
Pravina N Gurjar1★, Ashok V Bhosale2★ Corresponding author
- 1PDEA’S Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, INDIA.
- 2PDEA's Shankarrao Ursal College of Pharmaceutical Sciences and Research Centre, Kharadi, Pune, Maharashtra, INDIA.
CORRESPONDENCE
Pravina N Gurjar
PDEA’S Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, INDIA.
Received: 14-06-2022; Revised: 30-06-2022; Accepted: 01-08-2022.
Volume 15, Issue 2 · pp. 308–313 · PUBLISHED · DOI: 10.5530/jyp.2023.15.41
ABSTRACT
Background: The main goal of any drug delivery system is to achieve the desired concentration of the drug in blood or tissue, which is therapeutically effective and nontoxic for a prolonged period. Sitagliptin is a dipeptidyl peptidase 4 enzyme inhibitor used in the treatment of non-insulin-dependent diabetes mellitus. The purpose of this study was to design a flexible dosage form that controls the release and provides therapeutic effects with minimum side effects. Materials and Methods: Various batches of pellets were made using the extrusion spheronization technique for obtaining the batch that resulted in a sustained release pattern for Sitagliptin. Results: The pellets showed excellent flow properties due to sphericity thereby influencing the dosage production rate, the small particle that could easily disperse and help in avoiding the dose dumping. The pellets showed 89.10 % release in 12 hr. Conclusion:The study concludes the development of sustained-release pellets by selective excipients with better drug release minimizing the problems.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Gurjar, P. N., & Bhosale, A. V. (). Impact of Selective Polymer on Optimization of Sustained Release Matrix Pellets of Sitagliptin. Journal of Young Pharmacists, 15(2), 308–313. https://doi.org/10.5530/jyp.2023.15.41