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Preparation of Melatonin Nanoparticles and their Enhancement of Lungs Bioavailability in the Treatment of Lungs Cancer

Niyaz Ahmad1,2★, Mohammed Saifuddin Khalid3, Ayman Makki Al Ramadhan1, Mohammed Riyad Al Hammad1, Mohd Faiyaz Khan4, Ziyad Saeed Almalki4, Faisal K Alkholifi5, Zabih Ullah6, Mohd Ibrahim Khan7, Nazia Khan8★ Corresponding author

  1. 1Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.
  2. 2Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, INDIA.
  3. 3Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.
  4. 4Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al kharj, SAUDI ARABIA.
  5. 5Department of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, SAUDI ARABIA.
  6. 6Department of Pharmaceutical Sciences, College of Pharmacy and Dentistry, Buraydah Colleges, Alqassim, SAUDI ARABIA.
  7. 7Department of Pharmaceutical Sciences, SIHAS, Sam Higginbottom University of Agriculture Technology and Sciences (SHUATS), Allahabad, Uttar Pradesh, INDIA.
  8. 8Department of Pharmaceutical Sciences, Ibn Sina National College for Medical Studies, Jeddah, SAUDI ARABIA.

CORRESPONDENCE

Niyaz Ahmad

Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.

niyazpharma@gmail.com

Received: 19-10-2022; Revised: 27-11-2022; Accepted: 17-12-2022.

Volume 15, Issue 2 · pp. 314–325 · PUBLISHED · DOI: 10.5530/jyp.2023.15.42

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ABSTRACT

Background:To develop a first-time-novel polymeric NPs from PLGA and their coating by Chitosan (CS) of Melatonin (MT) for the enhancement of lungs bioavailability by targeting lungs from the nose. Materials and Methods: The Melatonin LC-MS/MS method was developed for the first time for a comparative Pulmokinetic evaluation administered by different routes which will be useful for the treatment of lung cancer and in vitro evaluation on lung cancer cell-lines (H1299). The solvent evaporation method was used to develop the PLGA nanoparticles and their encapsulation by CS. Results:CS MT PLGA MPs were given a significantly high release and permeation of MT as compared to MT PLGA NPs. Different routes of administration were used to compare the pulmokinetics parameters. Lung cancer cell lines (H1299) were used for anticancer activities. PDI, ZP, PS, DL, and EE of CS MT PLGA NPs were observed at 0.131±0.009, +19.5±1.37mV, 98.36±7.15 nm, 4.19±0.38%, and 74.16 ± 5.29% respectively. Mucoadhesive nature of CS MT PLGA NPs was showed greater than MT PLGA NPs and MT S with 0.303 retention time with mas’ spectra of 233.20/174.10. The developed method was linear (1–1000ng/mL) with inter and intra-day accuracy (91.68–98.95%) followed by precision (1.67—2.69%). Cmax and AUC0–24 were significantly enhanced (p<0.001) than i.v. and oral in the lungs. Conclusion: Capping of CS on PLGA NPs could be a strong possible nanocarrier for Melatonin to enhance their solubility of a drug (MT), entrapment, sustain and controlled release, and stability, with their therapeutic application.

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    Ahmad, N., Khalid, M. S., Ramadhan, A. M. A., Hammad, M. R. A., Khan, M. F., Almalki, Z. S., Alkholifi, F. K., Ullah, Z., Khan, M. I., & Khan, N. (). Preparation of Melatonin Nanoparticles and their Enhancement of Lungs Bioavailability in the Treatment of Lungs Cancer. Journal of Young Pharmacists, 15(2), 314–325. https://doi.org/10.5530/jyp.2023.15.42