jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Journal of Young PharmacistsNOW IN
Review

Liquid Chromatographic Techniques for the Qualitative and Quantitative Analysis of Cyclosporine and Gingerol: Advances in Rheumatoid Arthritis Management

Priyanka Kotla1, Rashmi Nelligare Gopalkrishna2★★ Corresponding author

  1. 1Smt. Sarojini Ramulamma College of Pharmacy, Mahabubnagar, Telangana, INDIA.
  2. 2Faculty of Pharmacy, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara, Mandya, Karnataka, INDIA.

CORRESPONDENCE

Rashmi Nelligare Gopalkrishna

Faculty of Pharmacy, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara, Mandya, Karnataka, INDIA.

ngrashmi@accp.co.in

Received: 07-02-2025; Revised: 14-04-2025; Accepted: 27-06-2025.

Volume 17, Issue 3 · pp. 504–510 · PUBLISHED · DOI: 10.5530/jyp.20251790

View on JYP original site ↗

ABSTRACT

This review focuses on the advancements in liquid chromatographic techniques to do both qualitative and quantitative research on cyclosporine and gingerol, with particular emphasis on their incorporation into Novel Drug Delivery Systems (NDDS) to improve the management of Rheumatoid Arthritis (RA). The review underscores the importance of robust analytical methods for ensuring the precision, stability, and efficacy of these therapeutic agents in the context of RA. Despite the availability of conventional therapies, challenges such as poor bioavailability, rapid metabolism, and systemic toxicity persist. The combination of cyclosporine, a potent immunosuppressant, and gingerol, a natural anti-inflammatory compound, presents a promising approach to addressing these challenges and enhancing patient management in RA. Furthermore, this review explores the pathophysiology of RA, highlighting the need for specialised medication administration systems, such as nanocarriers, that optimize drug bioavailability and specifically target inflamed joints, thereby improving therapeutic outcomes. The role of liquid chromatography in the analysis and quality control of cyclosporine and gingerol is also discussed, with an emphasis on the development of analytical methods to support the advancement of NDDS for RA therapy.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Kotla, P., & Gopalkrishna, R. N. (). Liquid Chromatographic Techniques for the Qualitative and Quantitative Analysis of Cyclosporine and Gingerol: Advances in Rheumatoid Arthritis Management. Journal of Young Pharmacists, 17(3), 504–510. https://doi.org/10.5530/jyp.20251790