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Insights on Sjögren's Syndrome: Beyond Dry Eye Symptoms

Debasis Patra1, Kirtimaya Mishra1, Asra Jabeen2, Prasanna Parida3, Abhilash Dash4, Gowri Sankar Chintapalli5, Diptimayee Jena1★★ Corresponding author

  1. 1School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha, INDIA.
  2. 2Department of Pharmacy, Bharat Institute of Technology, Mangalpally, Ibrahimpatnam, Telangana, INDIA.
  3. 3Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha, INDIA.
  4. 4Department of Pharmacy, Manikeswari Pharmacy School, Manikeswari Group of Institutions, Bhawanipatna, Kalahandi, Odisha, INDIA.
  5. 5School of Pharmaceutical Sciences, Centurion University of Technology and Management, Vizianagaram, Andhra Pradesh, INDIA.

CORRESPONDENCE

Diptimayee Jena

School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha, INDIA.

diptimayee.pharma@gmail.com

Received: 07-02-2025; Revised: 14-05-2025; Accepted: 24-07-2025.

Volume 17, Issue 3 · pp. 511–519 · PUBLISHED · DOI: 10.5530/jyp.20251687

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ABSTRACT

Sjögren's Syndrome (SS), a systemic autoimmune condition, that is characterised by the presence of dry eyes along with dry mouth. However, it is important to note that the effects of this disorder are not limited to these primary symptoms. This dissertation examines the complex nature of SS, investigating its various forms, the underlying immunological processes involved, and the consequences for diagnosing and treating the condition. In addition to causing dryness in the eyes and mouth, SS can also impact various other organ systems, resulting in consequences such as systemic inflammation, tiredness, joint discomfort, and organ dysfunction. This article provides a thorough examination of the current literature and clinical observations to elucidate the intricate nature of SS pathophysiology. It explores the involvement of lymphocytic infiltration, autoantibody production, and hereditary predisposition. Moreover, it explores the difficulties in diagnosing SS, highlighting the significance of thorough evaluation and interdisciplinary cooperation. Treatment strategies involve a comprehensive strategy focused on alleviating symptoms, maintaining organ function, and enhancing quality of life. This abstract seeks to expand our comprehension of SS beyond its symptoms related to dry eyes, with the goal of improving therapeutic treatment and promoting increased recognition of this frequently neglected autoimmune disorder.

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    Patra, D., Mishra, K., Jabeen, A., Parida, P., Dash, A., Chintapalli, G. S., & Jena, D. (). Insights on Sjögren's Syndrome: Beyond Dry Eye Symptoms. Journal of Young Pharmacists, 17(3), 511–519. https://doi.org/10.5530/jyp.20251687