Synthesis and Pharmacological Evaluation of Novel Schiff Base Analogues of 3-(4-amino) Phenylimino) 5-fluoroindolin-2-one
R Nirmal1★, CR Prakash2, K Meenakshi1, P Shanmugapandiyan1★ Corresponding author
- 1Department of Pharmaceutical Chemistry, Balaji Institute of Pharmacy, Laknepally (V), Narsampet (M), Warangal, Andhra Pradesh, INDIA.
- 2DCRM Pharmacy College, Inkollu (V), Prakasam (D) Andhra Pradesh, INDIA.
CORRESPONDENCE
R Nirmal
Department of Pharmaceutical Chemistry, Balaji Institute of Pharmacy, Laknepally (V), Narsampet (M), Warangal, Andhra Pradesh, INDIA.
Volume 2, Issue 2 · pp. 162–168 · PUBLISHED · DOI: 10.4103/0975-1483.63162
ABSTRACT
In our study, a series of novel 3-(4-(benzylideneamino) phenylimino) 4-fluoroindolin-2-one derivatives were synthesized and characterized by spectral (I.R, 1H NMR, mass) and elemental analysis. The title compounds (N1-N10) were evaluated for analgesic, anti-inflammatory, and ulcerogenic index activities. Results displayed that compound N3 exhibited significant analgesic activity. Among the title compounds studied, N2, N3, and N8 exhibited significant anti- inflammatory activity comparable to reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic side effect when compared to aspirin.
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Nirmal, R., Prakash, C., Meenakshi, K., & Shanmugapandiyan, P. (). Synthesis and Pharmacological Evaluation of Novel Schiff Base Analogues of 3-(4-amino) Phenylimino) 5-fluoroindolin-2-one. Journal of Young Pharmacists, 2(2), 162–168. https://doi.org/10.4103/0975-1483.63162