Synthesis and Evaluation of 1,3 Di-Substituted Schiff, Mannich Bases and Spiro Isatin Derivatives
Mondal P2, Banerjee M2, Jana S2, Bose A2★★ Corresponding author
- 1Department of Pharmaceutical Chemistry, Institute of Pharmacy and Technology, Salipur, Cuttack, INDIA.
- 2School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (SOA) University, Bhubneswer, Orissa, INDIA.
CORRESPONDENCE
Bose A
Department of Pharmaceutical Chemistry, Institute of Pharmacy and Technology, Salipur, Cuttack, INDIA.
Volume 2, Issue 2 · pp. 169–172 · PUBLISHED · DOI: 10.4103/0975-1483.63164
ABSTRACT
Schiff bases of isatin with aminothiazole, its N-mannich bases and Spiro isatin derivatives were synthesized. Their chemical structures were confirmed by Infrared, 1H-Nuclear Magnetic Resonance data and elemental analysis. Antimicrobial evaluation was performed by the agar diffusion method against four pathogenic bacteria and two pathogenic fungi. Anti-inflammatory activity was tested by carragenin-induced rat paw edema and compounds were evaluated for analgesic action by the acetic acid-induced writhing method; Compounds Aa, Ab and A5, A6 were found to be active against bacteria and fungi. The compounds A3, A6, Aa and Ab showed anti-inflammatory activity, having a percentage protection value of 34.69, 32.65, 38.77 and 36.73 as compared with that of indomethacin, with % protection of 46.93. Similarly, the compounds Aa, Ab and A6 showed analgesic activity, with % protection of 67.51, 64.78 and 49.81 as compared with the standard with % protection of 79.56.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
P, M., M, B., S, J., & A, B. (). Synthesis and Evaluation of 1,3 Di-Substituted Schiff, Mannich Bases and Spiro Isatin Derivatives. Journal of Young Pharmacists, 2(2), 169–172. https://doi.org/10.4103/0975-1483.63164