Liquid Chromatographic Determination of Flavoxate HCl in Pharmaceutical Formulation
Attimarad M1★★ Corresponding author
- 1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, KSA.
CORRESPONDENCE
Attimarad M
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, KSA.
Volume 2, Issue 3 · pp. 280–283 · PUBLISHED · DOI: 10.4103/0975-1483.66787
ABSTRACT
The objective of the study was to develop a high performance liquid chromatography (HPLC) method using ultra violet (UV) detection for the determination of flavoxate HCl in bulk and solid dosage forms by using ibuprofen as the internal standard. Eclipse C18 column (150 mm x 4.6 mm, 5 μm) was used as the stationary phase with a mixture of acetonitrile : 0.1% formic acid in water (75: 25 v/v) as the mobile phase. The response of the drug was linear in the concentration range of 1 – 250 μg/ml. Limit of detection and Limit of quantification were found to be 0.23 μg/ml and 0.69 μg/ml, respectively. The percentage of recovery ranged between 97.4 and 101.3%. The factors affecting column separation of the analyte were studied. The results demonstrated that this method is reliable, reproducible, and suitable for routine quantitative use.
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M, A. (). Liquid Chromatographic Determination of Flavoxate HCl in Pharmaceutical Formulation. Journal of Young Pharmacists, 2(3), 280–283. https://doi.org/10.4103/0975-1483.66787