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Journal of Young PharmacistsNOW IN
Article

Synthesis and Biological Evaluation of some 3b-hydroxy-lup-20(29)-en-28-oic Acid Derivatives

Prince Prashant Sharma1★, Anurag A2, Ram Kumar Roy3, Rajneesh Dutt Kaushik4, Vipin Kumar Sharma5★ Corresponding author

  1. 1Department of Pharmaceutical Sciences, Faculty of Medical Sciences and Health, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.
  2. 2Meerut Institute of Engineering and Technology (MIET), NH-58 Meerut-Delhi Bypass, Meerut, Uttar Pradesh, INDIA.
  3. 3Innovative College of Pharmacy, Knowledge Park-ii, Greater Noida, Uttar Pradesh, INDIA.
  4. 4Department of Chemistry, Faculty of Sciences, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.
  5. 5Department of Pharmaceutical Sciences, Faculty of Medical Sciences and Health, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.

CORRESPONDENCE

Prince Prashant Sharma

Department of Pharmaceutical Sciences, Faculty of Medical Sciences and Health, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.

princeb4me@rediffmail.com

Volume 8, Issue 4 · pp. 319–323 · PUBLISHED · DOI: 10.5530/jyp.2016.4.5

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ABSTRACT

Objective:The present study projected to the synthesis of 3b-Hydroxy-lup- 20(29)-en-28-oic acid analogues in order to evaluate their possible biological activity. In addition, the structure–activity relationship is also investigated. Method:BA derivatives were prepared by conjugating 3b-Hydroxy-lup- 20(29)-en-28-oic acid with different amines through carbomyl linkage. Structures of synthesized compounds were elucidated by spectral data. Cytotoxic evaluation was done by CAM assay and MTT assay. Results:Among the synthesized compounds, Compound 7showed a pronounced cytotoxicity in antiangiogenic assay as well as compound ECV-304 cell line. Compound 10 also showed good cytotoxic activity. While compounds 6 and 8 showed moderate activity against A-549 and MCF-7 respectively. Conclusion: It is concluded that synthesized BA analogues are biologically active and developed into useful anticancer agents.

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    Sharma, P. P., A, A., Roy, R. K., Kaushik, R. D., & Sharma, V. K. (). Synthesis and Biological Evaluation of some 3b-hydroxy-lup-20(29)-en-28-oic Acid Derivatives. Journal of Young Pharmacists, 8(4), 319–323. https://doi.org/10.5530/jyp.2016.4.5