Enhancing Transdermal Delivery of Glimepiride Via Entrapment in Proniosomal Gel
Marwa Helmy Abdallah1,2, Shereen Ahmed Sabry1, Azza Ali Hasan1★★ Corresponding author
- 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, EGYPT.
- 2Department of Pharmaceutics, College of Pharmacy, Hail University, KSA.
CORRESPONDENCE
Azza Ali Hasan
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, EGYPT.
Volume 8, Issue 4 · pp. 335–340 · PUBLISHED · DOI: 10.5530/jyp.2016.4.8
ABSTRACT
Objective: The aim of this study is to formulate and evaluate proniosomal gel formulations as transdermal delivery systems of glimepiride (GM) to improve its therapeutic efficacy. Methods:Proniosomal formulations have been prepared using different types of non-ionic surfactants with cholesterol in different molar ratios. Proniosomal gel; PN16 (Span 60, Tween 60, Cholesterol; 35:35:30 molar ratio) that exhibits maximum EE % (94.01 ± 0.88) and most prolonged release was chosen forex-vivo skin permeation andin-vivo hypoglycemic activity studies. Results:Proniosomal gel produced better permeation through rabbit skin than HPMC niosomal gel and HPMC gel. The pharmacokinetic parameters; time of maximum response (Tmax), % reduction in blood glucose concentration and area above the blood glucose levels-time curve (AAC) of proniosomal gel were studied. Proniosomal gel showed a controlled release behavior and a significantly higher hypoglycemic activity (65.34 ± 6.54%). Conclusion: It is evident from this study that proniosomal gel can act as an alternative approach for enhancing transdermal delivery of GM.
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Abdallah, M. H., Sabry, S. A., & Hasan, A. A. (). Enhancing Transdermal Delivery of Glimepiride Via Entrapment in Proniosomal Gel. Journal of Young Pharmacists, 8(4), 335–340. https://doi.org/10.5530/jyp.2016.4.8