jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Journal of Young PharmacistsNOW IN
Article

Application of 32 Factorial D-Optimal Design in Formulation of Porous Osmotic Pump Tablets of Ropinirole; An Anti-Parkinson’s Agent

Anoop Narayanan V1★, Praveena George2, Dhamelia Akshay L2★ Corresponding author

  1. 1Department of Pharmaceutics, NGSM Institute of Pharmaceutical sciences. NITTE University, Paneer, Mangalore - 575018, INDIA.
  2. 2Department of Pharmaceutics, Shree Devi College of Pharmacy, Airport Road, Kenjar, Mangalore, Karnataka, INDIA.

CORRESPONDENCE

Anoop Narayanan V

Department of Pharmaceutics, NGSM Institute of Pharmaceutical sciences. NITTE University, Paneer, Mangalore - 575018, INDIA.

anoopvn84@gmail.com

Received: 11-08-2016; Revised: 27-08-2016; Accepted: 15-09-2016.

Volume 9, Issue 1 · pp. 87–93 · PUBLISHED · DOI: 10.5530/jyp.2017.9.17

View on JYP original site ↗

ABSTRACT

Objective:In the present study, our objective was to develop porous osmotic pump tablets of an anti-Parkinson’s agent, ropinirole. It also aimed to demonstrate the applicability of factorial designs and there by a statistical optimization in developing a controlled drug releasing device. Methods:A 32 factorial D-optimal study design was adopted to identify an optimized formulation. Tablets were prepared by direct compression using varying amounts of microcrystalline cellulose (MCC) and sodium chloride, followed by coating with semipermeable membrane of cellulose acetate (CA) containing polyethylene glycol (PEG) 400 as a pore former. The plasticity of the membranes was adjusted using castor oil. All the formulations were evaluated for various physical parameters including in vitro drug release and the effect of osmogent and pore former were also studied. Drug release kinetics studies such as zero order, first order and Korsmeyer Peppas were carried out and compared. ANOVA in drug release of all the formulations were determined. Formulations were optimized by using numerical opti mization technique to achieve a controlled zero order release of ropinirole for 12 hours. Results:Drug release from the optimized formulation containing 20%w/w of PEG, without osmogent was not significantly affected by change in pH or agitation of the dissolution medium. The mechanism of drug release was further confirmed by studying the effect of osmotic pressure on drug release. Conclusion:The porous osmotic pump tablets of ropinirole can provide prolonged, controlled and GI environment-independent drug release. A software based optimization is helpful and reliable in devel oping porous osmotic pump tablets.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    V, A. N., George, P., & L, D. A. (). Application of 32 Factorial D-Optimal Design in Formulation of Porous Osmotic Pump Tablets of Ropinirole; An Anti-Parkinson’s Agent. Journal of Young Pharmacists, 9(1), 87–93. https://doi.org/10.5530/jyp.2017.9.17